Art

J-GLOBAL ID：201602260927515556   Reference number：16A1341639

Recent progress in development of transgenic silkworms overexpressing recombinant human proteins with therapeutic potential in silk glands

絹糸腺に治療可となる組換えヒトタンパク質を過剰発現させる遺伝子組み換えカイコ開発の最近の進歩

Author (6)： Itoh Kohji (Department of Medicinal Biotechnology, Institute for Medicinal Research, Graduate School of Pharmaceutical Sciences, Tokushima University) ,  Kobayashi Isao (National Institute of Agribioscience) ,  Nishioka So-ichiro (Department of Medicinal Biotechnology, Institute for Medicinal Research, Graduate School of Pharmaceutical Sciences, Tokushima University) ,  Sezutsu Hideki (National Institute of Agribioscience) ,  Machii Hiroaki (National Institute of Agribioscience) ,  Tamura Toshiki (National Institute of Agribioscience)
Material： Drug Discoveries & Therapeutics  (DD & T)
Volume： 10  Issue： 1  Page： 34-39(J-STAGE)  Publication year： 2016 
JST Material Number： F1177A  ISSN： 1881-7831  CODEN： DDTRBX  Document type： Article
Article type： 文献レビュー  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *silkworm ,...
Semi thesaurus term： *Lysosomal storage disease ,...

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Author keywords (5)： Transgenic silkworm ,  bio-medicine ,  lysosomal storage diseases ,  lysosomal enzyme replacement therapy ,  glycotechnology

JST classification (3)： Metabolic diseases,nutritional diseases in general.  (GD05010J) ,  Congenital diseases,deformities in general.  (GD03010V) ,  Laboratry organisms  (EA03070Y)

Substance index (1)： Mannose 6-phosphate

Reference (32)：

• 1. Tamura T, Thibert C, Royer C, Kanda T, Abraham E, Kamba M, Komoto N, Thomas JL, Mauchamp B, Chavancy G, Shirk P, Fraser M, Prudhomme JC, Couble P. Germline transformation of the silkworm Bombyx mori L. using a piggyBac transposon-derived vector. Nat Biotechnol. 2000;18:81-84.
• 2. Tomita M, Munetsuna H, Sato T, Adachi T, Hino R, Hayashi M, Shimizu K, Nakamura N, Tamura T, Yoshizato K. Transgenic silkworms produce recombinant human type III procollagen in cocoons. Nat Biotechnol. 2003; 21:52-56.
• 3. Shin S, Kim BY, Jeon HY, Lee A, Lee S, Sung SH, Park CS, Lee CK, Kong H, Song Y, Kim K. Expression system for production of bioactive compounds, recombinant human adiponectin, in the silk glands of transgenic silkworms. Arch Pharm Res. 2014; 37:645-651.
• 4. Xue R, Chen H, Cui L, Cao G, Zhou W, Zheng X, Gong C. Expression of hGM-CSF in silk glands of transgenic silkworms using gene targeting vector. Transgenic Res. 2012; 21:101-111.
• 5. Kurogochi M, Mori M, Osumi K, Tojino M, Sugawara S, Takashima S, Hirose Y, Tsukimura W, Mizuno M, Amano J, Matsuda A, Tomita M, Takayanagi A, Shoda S, Shirai T. Glycoengineered monoclonal antibodies with homogeneous glycan (M3, G0, G2, and A2) using a chemoenzymatic approach have different affinities for FcγRIIIa and variable antibody-dependent cellular cytotoxicity activities. PLoS One. 2015; 10:e0132848.

Terms in the title (8)： 絹糸腺 ,  治療 ,  組換え ,  ヒト ,  タンパク質 ,  過剰発現 ,  遺伝子組み換えカイコ ,  開発