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J-GLOBAL ID：201602260982604356   Reference number：16A0815222

Low Six4 and Six5 gene dosage improves dystrophic phenotype and prolongs life span of mdx mice

低いSix4およびSix5遺伝子の供与量はジストロフィー表現型を改善し,そしてmdxマウスの寿命を延長する

Author (2)： Yajima Hiroshi (Division of Biology, Center for Molecular Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan) ,  Kawakami Kiyoshi (Division of Biology, Center for Molecular Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan)
Material： Development, Growth & Differentiation  (Dev Growth Differ)
Volume： 58  Issue： 6  Page： 546-561  Publication year： Aug. 2016 
JST Material Number： W0832A  ISSN： 0012-1592  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： Mus musculus ,...
Semi thesaurus term： Duchenne muscular dystrophy ,...

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Author keywords (5)： mdx ,  muscle satellite cell ,  Six4 ,  Six5 ,  skeletal muscle regeneration

JST classification (3)： Basic medicine on musculoskeletal system  (GG01020B) ,  Muscles  (EJ10020G) ,  Biological function  (EB03040U)

Reference (76)：

• Ahn, A. H. & Kunkel, L. M. 1993. The structural and functional diversity of dystrophin. Nat. Genet. 3, 283-291.
• Amalfitano, A. & Chamberlain, J. S. 1996. The mdx-amplification-resistant mutation system assay, a simple and rapid polymerase chain reaction-based detection of the mdx allele. Muscle Nerve 19, 1549-1553.
• Anderson, J. E., Bressler, B. H. & Ovalle, W. K. 1988. Functional regeneration in the hindlimb skeletal muscle of the mdx mouse. J. Muscle Res. Cell MotiL 9, 499-515.
• Bonilla, E., Samitt, C. E., Miranda, A. F., Hays, A. P., Salviati, G., Dimauro, S., Kunkel, L. M., Hoffman, E. P. & Rowland, L. P. 1988. Duchenne muscular dystrophy: deficiency of dystrophin at the muscle cell surface. Cell 54, 447-452.
• Bulfield, G., Siller, W. G., Wight, P. A. & Moore, K. J. 1984. X chromosome-linked muscular dystrophy (mdx) in the mouse. Proc. Natl Acad. ScL USA 81, 1189-1192.

Terms in the title (5)： 遺伝子 ,  ジストロフィー ,  表現型 ,  MDXマウス ,  寿命