Art

J-GLOBAL ID：201602262267544611   Reference number：16A1259931

Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma

分子プロファイリングはびまん性神経膠腫進行の生物学的に離散したサブセットおよび経路を明らかにする

Author (58)： Ceccarelli Michele (Qatar Computing Research Institute, Hamad Bin Khalifa University, Doha P.O. box 5825, Qatar) ,  Ceccarelli Michele (Department of Science and Technology, University of Sannio, Benevento 82100, Italy) ,  Barthel Floris P. (Department of Genomic Medicine, Department of Bioinformatics and Computational Biology, Department of Biostatistics, Department of Neuro-Oncology, Department of Neurosurgery, Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA) ,  Barthel Floris P. (Oncology Graduate School Amsterdam, Department of Pathology, VU University Medical Center, 1081 HV Amsterdam, the Netherlands) ,  Malta Tathiane M. (Department of Genetics (CISBi/NAP), Department of Surgery and Anatomy, Ribeirao Preto Medical School, University of Sao Paulo, Monte Alegre, Ribeirao Preto-SP CEP: 14049-900, Brazil) ,  Malta Tathiane M. (Center for Integrative Systems Biology (CISBi, NAP/USP), Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo 14049-900, Brazil) ,  Sabedot Thais S. (Department of Genetics (CISBi/NAP), Department of Surgery and Anatomy, Ribeirao Preto Medical School, University of Sao Paulo, Monte Alegre, Ribeirao Preto-SP CEP: 14049-900, Brazil) ,  Sabedot Thais S. (Center for Integrative Systems Biology (CISBi, NAP/USP), Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo 14049-900, Brazil) ,  Salama Sofie R. (UC Santa Cruz Genomics Institute, University of California, Santa Cruz, Santa Cruz, CA 95064, USA) ,  Murray Bradley A. (The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA) ,  Morozova Olena (UC Santa Cruz Genomics Institute, University of California, Santa Cruz, Santa Cruz, CA 95064, USA) ,  Newton Yulia (UC Santa Cruz Genomics Institute, University of California, Santa Cruz, Santa Cruz, CA 95064, USA) ,  Radenbaugh Amie (UC Santa Cruz Genomics Institute, University of California, Santa Cruz, Santa Cruz, CA 95064, USA) ,  Pagnotta Stefano M. (Department of Science and Technology, University of Sannio, Benevento 82100, Italy) ,  Pagnotta Stefano M. (BIOGEM Istituto di Ricerche Genetiche “G. Salvatore,” Campo Reale, 83031 Ariano Irpino, Italy) ,  Anjum Samreen (Qatar Computing Research Institute, Hamad Bin Khalifa University, Doha P.O. box 5825, Qatar) ,  Wang Jiguang (Department of Neurology, Department of Pathology, Institute for Cancer Genetics, Department of Systems Biology and Biomedical Informatics, Columbia University Medical Center, New York, NY 10032, USA) ,  Manyam Ganiraju (Department of Genomic Medicine, Department of Bioinformatics and Computational Biology, Department of Biostatistics, Department of Neuro-Oncology, Department of Neurosurgery, Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA) ,  Zoppoli Pietro (Department of Neurology, Department of Pathology, Institute for Cancer Genetics, Department of Systems Biology and Biomedical Informatics, Columbia University Medical Center, New York, NY 10032, USA) ,  Ling Shiyun (Department of Genomic Medicine, Department of Bioinformatics and Computational Biology, Department of Biostatistics, Department of Neuro-Oncology, Department of Neurosurgery, Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA) ,  Rao Arjun A. (UC Santa Cruz Genomics Institute, University of California, Santa Cruz, Santa Cruz, CA 95064, USA) ,  Grifford Mia (UC Santa Cruz Genomics Institute, University of California, Santa Cruz, Santa Cruz, CA 95064, USA) ,  Cherniack Andrew D. (The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA) ,  Zhang Hailei (The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA) ,  Poisson Laila (Henry Ford Hospital, Detroit, MI 48202, USA) ,  Carlotti Carlos Gilberto (Department of Genetics (CISBi/NAP), Department of Surgery and Anatomy, Ribeirao Preto Medical School, University of Sao Paulo, Monte Alegre, Ribeirao Preto-SP CEP: 14049-900, Brazil) ,  Carlotti Carlos Gilberto (Center for Integrative Systems Biology (CISBi, NAP/USP), Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo 14049-900, Brazil) ,  Tirapelli Daniela Pretti da Cunha (Department of Genetics (CISBi/NAP), Department of Surgery and Anatomy, Ribeirao Preto Medical School, University of Sao Paulo, Monte Alegre, Ribeirao Preto-SP CEP: 14049-900, Brazil) ,  Tirapelli Daniela Pretti da Cunha (Center for Integrative Systems Biology (CISBi, NAP/USP), Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo 14049-900, Brazil) ,  Rao Arvind (Department of Genomic Medicine, Department of Bioinformatics and Computational Biology, Department of Biostatistics, Department of Neuro-Oncology, Department of Neurosurgery, Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA) ,  Mikkelsen Tom (Henry Ford Hospital, Detroit, MI 48202, USA) ,  Lau Ching C. (Texas Children’s Hospital, Houston, TX 77030, USA) ,  Lau Ching C. (Baylor College of Medicine, Houston, TX 77030, USA) ,  Yung W.K. Alfred (Department of Genomic Medicine, Department of Bioinformatics and Computational Biology, Department of Biostatistics, Department of Neuro-Oncology, Department of Neurosurgery, Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA) ,  Rabadan Raul (Department of Neurology, Department of Pathology, Institute for Cancer Genetics, Department of Systems Biology and Biomedical Informatics, Columbia University Medical Center, New York, NY 10032, USA) ,  Huse Jason (Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA) ,  Brat Daniel J. (Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA) ,  Lehman Norman L. (Department of Pathology, The Ohio State University, Columbus, OH 43210, USA) ,  Barnholtz-Sloan Jill S. (Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA) ,  Zheng Siyuan (Department of Genomic Medicine, Department of Bioinformatics and Computational Biology, Department of Biostatistics, Department of Neuro-Oncology, Department of Neurosurgery, Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA) ,  Hess Kenneth (Department of Genomic Medicine, Department of Bioinformatics and Computational Biology, Department of Biostatistics, Department of Neuro-Oncology, Department of Neurosurgery, Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA) ,  Rao Ganesh (Department of Genomic Medicine, Department of Bioinformatics and Computational Biology, Department of Biostatistics, Department of Neuro-Oncology, Department of Neurosurgery, Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA) ,  Meyerson Matthew (The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA) ,  Meyerson Matthew (Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA) ,  Beroukhim Rameen (The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA) ,  Beroukhim Rameen (Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA) ,  Beroukhim Rameen (Department of Medicine, Harvard Medical School, Boston, MA 02215, USA) ,  Cooper Lee (Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA) ,  Akbani Rehan (Department of Genomic Medicine, Department of Bioinformatics and Computational Biology, Department of Biostatistics, Department of Neuro-Oncology, Department of Neurosurgery, Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA) ,  Wrensch Margaret (Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94158, USA) ,  Haussler David (UC Santa Cruz Genomics Institute, University of California, Santa Cruz, Santa Cruz, CA 95064, USA) ,  Aldape Kenneth D. (Princess Margaret Cancer Centre, Toronto, ON M5G 2M9, Canada) ,  Laird Peter W. (Van Andel Research Institute, Grand Rapids, MI 49503, USA) ,  Gutmann David H. (School of Medicine, Washington University, St. Louis, MO 63110, USA) ,  Noushmehr Houtan (Department of Genetics (CISBi/NAP), Department of Surgery and Anatomy, Ribeirao Preto Medical School, University of Sao Paulo, Monte Alegre, Ribeirao Preto-SP CEP: 14049-900, Brazil) ,  Noushmehr Houtan (Center for Integrative Systems Biology (CISBi, NAP/USP), Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo 14049-900, Brazil) ,  Iavarone Antonio (Department of Neurology, Department of Pathology, Institute for Cancer Genetics, Department of Systems Biology and Biomedical Informatics, Columbia University Medical Center, New York, NY 10032, USA) ,  Verhaak Roel G.W. (Department of Genomic Medicine, Department of Bioinformatics and Computational Biology, Department of Biostatistics, Department of Neuro-Oncology, Department of Neurosurgery, Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA)
Material： Cell (Cambridge, Mass.)  (Cell (Camb. Mass.))
Volume： 164  Issue： 3  Page： 550-563  Publication year： Jan. 28, 2016 
JST Material Number： A0707B  ISSN： 0092-8674  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： human ,  *glioma ,  cohort study ,  gene ,  *Genome-Wide Association Study ,  telomere ,  homeostasis ,  Methylation ,  gene expression ,  pathophysiology ,  isocitrate dehydrogenase ,  ATRX gene ,  DNA Methylation ,  IDH1 gene ,  IDH2 gene ,  TERT gene ,  Genetic Profile ,  Genes, Neoplasm ,  *Genetic Variation ,  Telomere Homeostasis ,  molecular genetic phenomenon
Semi thesaurus term： *genetic variation ,  genome cohort study ,  Telomere length maintenance ,  びまん性神経膠腫

JST classification (4)： Basic oncology in general  (GE02010R) ,  Genetic variation  (EC01030Y) ,  Gene expression  (EC02040Q) ,  Tumors(=neoplasms)of nervous system  (GN04000V)

Terms in the title (5)： 分子プロファイリング ,  神経膠腫 ,  生物学 ,  サブ ,  経路