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J-GLOBAL ID：201602266503084514   Reference number：16A0712967

Bioinformatic identification of cytochrome b ₅ homologues from the parasitic nematode Ascaris suum and the free-living nematode Caenorhabditis elegans highlights the crucial role of A. suum adult-specific secretory cytochrome b ₅ in parasitic adaptation

線虫類Ascaris suumと自由生活線虫類Caenorhabditis elegans由来のチトクロームb₅同族体のバイオインフォーマティクス同定は寄生虫適合におけるA.suum成虫特異的分泌性チトクロームb₅の重要な役割を示す

Author (12)： Takamiya Shinzaburo (Department of Molecular and Cellular Parasitology, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan) ,  Takamiya Shinzaburo (Department of Parasitology, National Institute of Infectious Diseases, Toyama 1-23-1, Shinjuku-ku, Tokyo 162-8640, Japan) ,  Hashimoto Muneaki (Department of Molecular and Cellular Parasitology, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan) ,  Mita Toshihiro (Department of Molecular and Cellular Parasitology, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan) ,  Yokota Takehiro (R & D Strategy Department, Yokohama Research Center, Mitsubishi Chemical Corporation, 1000 Kamoshida-cho, Aoba, Yokohama 227-8502, Japan) ,  Nakajima Yoshitaka (Department of Life Science, Faculty of Science and Engneering, Setsunan University, 17-8 Ikeda-naka-machi, Neyagawa, Osaka 572-8508, Japan) ,  Yamakura Fumiyuki (Department of Chemistry, Faculty of International Liberal Arts, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan) ,  Sugio Shigetoshi (R & D Strategy Department, Yokohama Research Center, Mitsubishi Chemical Corporation, 1000 Kamoshida-cho, Aoba, Yokohama 227-8502, Japan) ,  Fujimura Tsutomu (Laboratory of Proteomics and Biomolecular Science, Biomedical Research Center, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan) ,  Ueno Takashi (Laboratory of Proteomics and Biomolecular Science, Biomedical Research Center, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan) ,  Yamasaki Hiroshi (Department of Molecular and Cellular Parasitology, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan) ,  Yamasaki Hiroshi (Department of Parasitology, National Institute of Infectious Diseases, Toyama 1-23-1, Shinjuku-ku, Tokyo 162-8640, Japan)
Material： Parasitology International  (Parasitol Int)
Volume： 65  Issue： 2  Page： 113-120  Publication year： Apr. 2016 
JST Material Number： W0965A  ISSN： 1383-5769  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： *Ascaris ,...
Semi thesaurus term： *Caenorhabditis elegans ,...

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Author keywords (5)： NADH-metmyo (hemo) globin reductase system ,  Secretory cytochrome b ₅ ,  NADH: ferricytochrome-b ₅ oxidoreductase ,  Ascaris suum ,  Caenorhabditis elegans

JST classification (2)： Enzyme physiology  (EG03052C) ,  Other computer utilization technology  (JE14000C)

Substance index (1)： NADH

Reference (22)：

• F. Lederer, The cytochrome b₅-fold: an adaptable module, Biochimie 76 (1994) 674-692.
• G. Vergeres, L. Waskell, Cytochrome b₅, its functions, structure and membrane topology, Biochimie 77 (1995) 604-620.
• J. Mitoma, A. Ito, The carboxy-terminal 10 amino acid residues of cytochrome b₅ are necessary for its targeting to the endoplasmic reticulum, EMBO J. 11 (1992) 4197-4203.
• R. Kuroda, T. Ikenoue, M. Honsho, S. Tsujimoto, J. Mitoma, A. Ito, Charged amino acids at the carboxyl-terminal portions determine the intracellular locations of two isoforms of cytochrome b₅, J. Biol. Chem. 273 (1998) 31097-31102.
• N. Oshino, T. Omura, Immunochemical evidence for the participation of cytochrome b₅ in microsomal stearyl-CoA denaturation reaction, Arch. Biochem. Biophys. 157 (1973) 395-404.

Terms in the title (11)： 線虫類 ,  Ascaris ,  自由生活線虫 ,  チトクロームb5 ,  同族体 ,  バイオインフォーマティクス ,  同定 ,  寄生虫 ,  成虫 ,  分泌 ,  役割