Art

J-GLOBAL ID：201602268291668320   Reference number：16A1227418

Design, Synthesis and Biological Evaluation of a Structurally Simplified Syringolin A Analogues

構造的に単純化されたシリンゴリンA類縁体の設計と合成および生物学的評価

Author (6)： Chiba Takuya (Faculty of Pharmaceutical Science, Hokkaido University) ,  Kitahata Shun (Faculty of Pharmaceutical Science, Hokkaido University) ,  Matsuda Akira (Faculty of Pharmaceutical Science, Hokkaido University) ,  Matsuda Akira (Center for Research and Education on Drug Discovery, Faculty of Pharmaceutical Science, Hokkaido University) ,  Ichikawa Satoshi (Faculty of Pharmaceutical Science, Hokkaido University) ,  Ichikawa Satoshi (Center for Research and Education on Drug Discovery, Faculty of Pharmaceutical Science, Hokkaido University)
Material： Chemical and Pharmaceutical Bulletin  (Chemical & Pharmaceutical Bulletin)
Volume： 64  Issue： 7  Page： 811-816(J-STAGE)  Publication year： 2016 
JST Material Number： G0504A  ISSN： 0009-2363  CODEN： CPBTAL  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *proteinase inhibitor ,...
Semi thesaurus term： *proteasome inhibitor ,...

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Author keywords (6)： proteasome ,  natural product ,  anticancer ,  proteasome ,  natural product ,  anticancer

JST classification (4)： Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W) ,  Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Eight or more-membered heterocyclic compounds  (CF07120T) ,  Cyclization reaction,ring-opening reaction  (CF02050I)

Substance index (2)： Syringolin A ,  N-[(3E,5S,8S,9E)-5-Isopropyl-2,7-dioxo-1,6-diazacyclododecane-3,9-diene-8β-yl]decanamide

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• 5) Lü S., Wang J., Biomarker Res., 1, 13 (2013).

Terms in the title (5)： 単純化 ,  シリンゴリンA ,  類縁体 ,  設計 ,  生物学的評価