Art

J-GLOBAL ID：201602269459667904   Reference number：16A1325466

Genomic and Transcriptomic Features of Response to Anti-PD-1 Therapy in Metastatic Melanoma

転移性メラノーマ(黒色腫)の抗PD-1療法に対する反応のゲノムおよびトランスクリプトームの特徴

Author (31)： Hugo Willy (Division of Dermatology, Department of Medicine, University of California, Los Angeles, CA 90095-1662, USA) ,  Hugo Willy (David Geffen School of Medicine, University of California, Los Angeles, CA 90095-1662, USA) ,  Zaretsky Jesse M. (Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095-1662, USA) ,  Zaretsky Jesse M. (David Geffen School of Medicine, University of California, Los Angeles, CA 90095-1662, USA) ,  Sun Lu (Division of Dermatology, Department of Medicine, University of California, Los Angeles, CA 90095-1662, USA) ,  Sun Lu (David Geffen School of Medicine, University of California, Los Angeles, CA 90095-1662, USA) ,  Song Chunying (Division of Dermatology, Department of Medicine, University of California, Los Angeles, CA 90095-1662, USA) ,  Song Chunying (David Geffen School of Medicine, University of California, Los Angeles, CA 90095-1662, USA) ,  Moreno Blanca Homet (Division of Hematology & Oncology, Department of Medicine, University of California, Los Angeles, CA 90095-1662, USA) ,  Hu-Lieskovan Siwen (Division of Hematology & Oncology, Department of Medicine, University of California, Los Angeles, CA 90095-1662, USA) ,  Berent-Maoz Beata (Division of Hematology & Oncology, Department of Medicine, University of California, Los Angeles, CA 90095-1662, USA) ,  Pang Jia (Division of Hematology & Oncology, Department of Medicine, University of California, Los Angeles, CA 90095-1662, USA) ,  Chmielowski Bartosz (Division of Hematology & Oncology, Department of Medicine, University of California, Los Angeles, CA 90095-1662, USA) ,  Cherry Grace (Division of Hematology & Oncology, Department of Medicine, University of California, Los Angeles, CA 90095-1662, USA) ,  Seja Elizabeth (Division of Hematology & Oncology, Department of Medicine, University of California, Los Angeles, CA 90095-1662, USA) ,  Lomeli Shirley (Division of Dermatology, Department of Medicine, University of California, Los Angeles, CA 90095-1662, USA) ,  Lomeli Shirley (David Geffen School of Medicine, University of California, Los Angeles, CA 90095-1662, USA) ,  Kong Xiangju (Division of Dermatology, Department of Medicine, University of California, Los Angeles, CA 90095-1662, USA) ,  Kong Xiangju (David Geffen School of Medicine, University of California, Los Angeles, CA 90095-1662, USA) ,  Kelley Mark C. (Department of Surgery, Vanderbilt-Ingram Cancer Center, Nashville, TN 37232, USA) ,  Sosman Jeffrey A. (Department of Medicine, Vanderbilt-Ingram Cancer Center, Nashville, TN 37232, USA) ,  Johnson Douglas B. (Department of Medicine, Vanderbilt-Ingram Cancer Center, Nashville, TN 37232, USA) ,  Ribas Antoni (Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095-1662, USA) ,  Ribas Antoni (Division of Hematology & Oncology, Department of Medicine, University of California, Los Angeles, CA 90095-1662, USA) ,  Ribas Antoni (Division of Surgical Oncology, Department of Surgery, University of California, Los Angeles, CA 90095-1662, USA) ,  Ribas Antoni (Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA 90095-1662, USA) ,  Ribas Antoni (David Geffen School of Medicine, University of California, Los Angeles, CA 90095-1662, USA) ,  Lo Roger S. (Division of Dermatology, Department of Medicine, University of California, Los Angeles, CA 90095-1662, USA) ,  Lo Roger S. (Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095-1662, USA) ,  Lo Roger S. (Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA 90095-1662, USA) ,  Lo Roger S. (David Geffen School of Medicine, University of California, Los Angeles, CA 90095-1662, USA)
Material： Cell (Cambridge, Mass.)  (Cell (Camb. Mass.))
Volume： 165  Issue： 1  Page： 35-44  Publication year： Mar. 24, 2016 
JST Material Number： A0707B  ISSN： 0092-8674  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： human ,  *malignant melanoma ,  *antibody ,  genome ,  Transcriptome ,  Mutation ,  survival ratio ,  tumor suppressor protein ,  Drug Resistance ,  gene expression ,  MAP kinase ,  BRCA2 Protein ,  *anti PD-L1 antibody ,  molecular genetic phenomenon
Semi thesaurus term： *Metastatic melanoma

JST classification (2)： Basic oncology in general  (GE02010R) ,  Skin tumors(=neoplasms)  (GF04000X)

Terms in the title (6)： 転移性メラノーマ ,  黒色腫 ,  PD-1 ,  療法 ,  ゲノム ,  トランスクリプトーム