Art

J-GLOBAL ID：201602271031734637   Reference number：16A0835458

Development of a 3′-amino linker with high conjugation activity and its application to conveniently cross-link blunt ends of a duplex

高い複合活性を有する3′-アミノリンカーの開発と二重鎖の鈍端部共有結合架橋結合へのその応用

Author (3)： Kowata Keiko (Bioproduction Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), 2-17-2-1 Tsukisamu-Higashi, Toyohira-ku, Sapporo 062-8517, Japan) ,  Kojima Naoshi (Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), 1-1-1 Tsukuba Central 6, Higashi, Tsukuba-shi, Ibaraki 305-8566, Japan) ,  Komatsu Yasuo (Bioproduction Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), 2-17-2-1 Tsukisamu-Higashi, Toyohira-ku, Sapporo 062-8517, Japan)
Material： Bioorganic & Medicinal Chemistry  (Bioorganic and Medicinal Chemistry)
Volume： 24  Issue： 9  Page： 2108-2113  Publication year： May. 01, 2016 
JST Material Number： W0556A  ISSN： 0968-0896  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： *carbamate ,  crosslinking ,  *oligonucleotide ,  *chemical modification ,  *antisense RNA ,  loop structure ,  molecular targeting drug ,  biotinylation ,  fluorescent labeling ,  linker ,  *MicroRNAs
Semi thesaurus term： nucleic acid medicine

Author keywords (6)： Amino linker ,  Nucleic acids ,  Oligonucleotides ,  Labeling ,  Cross-link ,  anti-microRNA

JST classification (1)： Nucleic acids in general  (EB04010U)

Terms in the title (6)： 活性 ,  開発 ,  重鎖 ,  共有結合 ,  架橋結合 ,  応用