Art

J-GLOBAL ID：201602284326682658   Reference number：16A1175958

Withaferin A suppresses the growth of myelodysplasia and leukemia cell lines by inhibiting cell cycle progression

ウィザフェリンAは骨髄形成異常および白血病細胞株の成長を細胞周期の進行を阻害することで抑制する

Author (7)： Okamoto Shuichiro (Department of Laboratory Medicine, Kawasaki Medical School, Okayama, Japan) ,  Tsujioka Takayuki (Department of Laboratory Medicine, Kawasaki Medical School, Okayama, Japan) ,  Suemori Shin-ichiro (Department of Laboratory Medicine, Kawasaki Medical School, Okayama, Japan) ,  Kida Jun-ichiro (Department of Laboratory Medicine, Kawasaki Medical School, Okayama, Japan) ,  Kondo Toshinori (Division of Hematology, Department of Internal Medicine, Kawasaki Medical School, Okayama, Japan) ,  Tohyama Yumi (Division of Biochemistry, Faculty of Pharmaceutical Sciences, Himeji Dokkyo University, Hyogo, Japan) ,  Tohyama Kaoru (Department of Laboratory Medicine, Kawasaki Medical School, Okayama, Japan. [e-mail])
Material： Cancer Science (Web)  (Cancer Sci (Web))
Volume： 107  Issue： 9  Page： 1302-1314  Publication year： 2016 
JST Material Number： U0505A  ISSN： 1349-7006  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *myelodysplastic syndrome ,...
Semi thesaurus term： G2/M period ,...

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Author keywords (5)： Acute myeloid leukemia ,  gene set enrichment analysis ,  heme oxygenase-1 ,  myelodysplastic syndromes ,  withaferin A

JST classification (3)： Blood cell tumors(=neoplasms)  (GK04000M) ,  Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N) ,  Basic research of antitumor(=antineoplastic)drugs  (GW16010A)

Substance index (1)： Withaferin A

Reference (35)：

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• Stein EM. Molecularly targeted therapies for acute myeloid leukemia. Hematology Am Soc Hematol Educ Program 2015; 2015: 579-83.
• Hahm ER, Singh SV. Autophagy fails to alter withaferin A-mediated lethality in human breast cancer cells. Curr Cancer Drug Targets 2013; 13 : 640-50.
• Nishikawa Y, Okuzaki D, Fukushima K et al. Withaferin A induces cell death selectively in androgen-independent prostate cancer cells but not in normal fibroblast cells. PLoS ONE 2015; 10: e0134137.
• Rai M, Jogee PS, Agarkar G, Santos CA. Anticancer activities of Withania somnifera: Current research, formulations, and future perspectives. Pharm Biol 2016; 54: 189-97.

Terms in the title (6)： 骨髄形成異常 ,  白血病 ,  細胞株 ,  成長 ,  細胞周期 ,  阻害