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J-GLOBAL ID：201602285540716214   Reference number：16A1175908

Identification of cooperative genes for E2A-PBX1 to develop acute lymphoblastic leukemia

急性リンパ芽球性白血病を発症するE2A-PBX1の共通遺伝子の同定

Author (8)： Sera Yasuyuki (Department of Disease Model, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan) ,  Yamasaki Norimasa (Department of Disease Model, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan) ,  Oda Hideaki (Department of Pathology, Tokyo Women’s Medical University, Tokyo, Japan) ,  Nagamachi Akiko (Department of Molecular Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan) ,  Wolff Linda (Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA) ,  Inukai Takeshi (Department of Pediatrics, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan) ,  Inaba Toshiya (Department of Molecular Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan) ,  Honda Hiroaki (Department of Disease Model, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan)
Material： Cancer Science (Web)  (Cancer Sci (Web))
Volume： 107  Issue： 7  Page： 890-898  Publication year： 2016 
JST Material Number： U0505A  ISSN： 1349-7006  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *lymphocytic leukemia ,...
Semi thesaurus term： *genetic variation ,...

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Author keywords (5)： Acute lymphoblastic leukemia ,  conditional knock-in mice ,  E2A-PBX1 ,  retroviral insertional mutagenesis ,  Zfp521/ZNF521

JST classification (3)： Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N) ,  Blood cell tumors(=neoplasms)  (GK04000M) ,  Molecular genetics in general  (EC02010J)

Reference (45)：

• Look AT. Oncogenic transcription factors in the human acute leukemias. Science 1997; 278: 1059-64.
• Murre C. Regulation and function of the E2A proteins in B cell development. Adv Exp Med Biol 2007; 596:1-7.
• Hunger SP, Galili N, Carroll AJ, Crist WM, Link MP, Cleary ML. The t (1;19)(q23;p13) results in consistent fusion of E2A and PBX1 coding sequences in acute lymphobla stic leukemias. Blood 1991; 77: 687-93.
• Kamps MP, Look AT, Baltimore D. The human t(1;19) translocation in pre-B ALL produces multiple nuclear E2A-Pbx1 fusion proteins with differing transforming potentials. Genes Dev 1991; 5: 358-68.
• Inaba T, Roberts WM, Shapiro LH et al. Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia. Science 1992; 257: 531-4.

Terms in the title (5)： 急性リンパ芽球性白血病 ,  発症 ,  E2A ,  遺伝子 ,  同定