Art

J-GLOBAL ID：201602286699774003   Reference number：16A1276477

Inhibition of neutrophil superoxide generation by shikonin is associated with suppression of cellular Ca²⁺ fluxes

細胞Ca²⁺流の抑制を伴ったシコニンによる好中球のスーパーオキシド生成の阻害

Author (9)： Kazumura Kimiko (Central Research Laboratory, Hamamatsu Photonics K.K.,) ,  Yoshida Lucia Satiko (Research Institute of Pharmaceutical Sciences, Musashino University) ,  Hara Akiko (Central Research Laboratory, Hamamatsu Photonics K.K.,) ,  Tsuchiya Hiroshi (Central Research Laboratory, Hamamatsu Photonics K.K.,) ,  Morishita Naokazu (Electron Tube Division, Hamamatsu Photonics K.K.) ,  Kawagishi Hirokazu (Department of Applied Biological Chemistry, Shizuoka University) ,  Kakegawa Tomohito (Faculty of Pharmaceutical Sciences, Josai International University) ,  Yuda Yasukatsu (Research Institute of Pharmaceutical Sciences, Musashino University) ,  Takano-Ohmuro Hiromi (Research Institute of Pharmaceutical Sciences, Musashino University)
Material： Journal of Clinical Biochemistry and Nutrition  (JCBN)
Volume： 59  Issue： 1  Page： 1-9(J-STAGE)  Publication year： 2016 
JST Material Number： X0851A  ISSN： 0912-0009  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： Neutrophils ,...
Semi thesaurus term： IC50 ,...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=16A1276477&from=J-GLOBAL&jstjournalNo=X0851A") }}

Author keywords (5)： simultaneous detection ,  intracellular calcium ,  superoxide ,  NADPH oxidase ,  shikonin

JST classification (1)： Basic research of anti-inflammatory drugs  (GW15010T)

Substance index (3)： N-Formylmethionine Leucyl-Phenylalanine ,  Inositol 1,4,5-Trisphosphate ,  Shikonin

Reference (46)：

• 1 Ishibashi K, Okazaki S, Hiramatsu M. Simultaneous measurement of superoxide generation and intracellular Ca²⁺ concentration reveals the effect of extracellular Ca²⁺ on rapid and transient contents of superoxide generation in differentiated THP-1 cells. Biochem Biophys Res Commun 2006; 344: 571-580.
• 2 Satozono H, Kazumura K, Okazaki S, Hiramatsu M. Simultaneous measurement of superoxide generation and intracellular calcium ion of neutrophil-like culture cells. Luminescence 2006; 21: 69-71.
• 3 Kazumura K, Sato Y, Satozono H, et al. Simultaneous monitoring of superoxides and intracellular calcium ions in neutrophils by chemiluminescence and fluorescence: evaluation of action mechanisms of bioactive compounds in foods. J Pharm Biomed Anal 2013; 84: 90-96.
• 4 Bréchard S, Tschirhart EJ. Regulation of superoxide production in neutrophils: role of calcium influx. J Leukoc Biol 2008; 84: 1223-1237.
• 5 Foyouzi-Youssefi R, Petersson F, Lew DP, Krause KH, Nüsse O. Chemoattractant-induced respiratory burst: increases in cytosolic Ca²⁺ concentrations are essential and synergize with a kinetically distinct second signal. Biochem J 1997; 322: 709-718.

Terms in the title (5)： 細胞 ,  シコニン ,  好中球 ,  スーパーオキシド ,  阻害