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J-GLOBAL ID：201602286699774003   Reference number：16A1276477

Inhibition of neutrophil superoxide generation by shikonin is associated with suppression of cellular Ca²⁺ fluxes

細胞Ca²⁺流の抑制を伴ったシコニンによる好中球のスーパーオキシド生成の阻害

Author (9)： Kazumura Kimiko (Central Research Laboratory, Hamamatsu Photonics K.K.,) ,  Yoshida Lucia Satiko (Research Institute of Pharmaceutical Sciences, Musashino University) ,  Hara Akiko (Central Research Laboratory, Hamamatsu Photonics K.K.,) ,  Tsuchiya Hiroshi (Central Research Laboratory, Hamamatsu Photonics K.K.,) ,  Morishita Naokazu (Electron Tube Division, Hamamatsu Photonics K.K.) ,  Kawagishi Hirokazu (Department of Applied Biological Chemistry, Shizuoka University) ,  Kakegawa Tomohito (Faculty of Pharmaceutical Sciences, Josai International University) ,  Yuda Yasukatsu (Research Institute of Pharmaceutical Sciences, Musashino University) ,  Takano-Ohmuro Hiromi (Research Institute of Pharmaceutical Sciences, Musashino University)
Material： Journal of Clinical Biochemistry and Nutrition  (JCBN)
Volume： 59  Issue： 1  Page： 1-9(J-STAGE)  Publication year： 2016 
JST Material Number： X0851A  ISSN： 0912-0009  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： neutrophils ,...
Semi thesaurus term： IC50 ,...

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Author keywords (5)： simultaneous detection ,  intracellular calcium ,  superoxide ,  NADPH oxidase ,  shikonin

JST classification (1)： Basic research of anti-inflammatory drugs  (GW15010T)

Substance index (3)： N-Formylmethionine Leucyl-Phenylalanine ,  Inositol 1,4,5-Trisphosphate ,  Shikonin

Reference (46)：

• 1 Ishibashi K, Okazaki S, Hiramatsu M. Simultaneous measurement of superoxide generation and intracellular Ca²⁺ concentration reveals the effect of extracellular Ca²⁺ on rapid and transient contents of superoxide generation in differentiated THP-1 cells. Biochem Biophys Res Commun 2006; 344: 571-580.
• 2 Satozono H, Kazumura K, Okazaki S, Hiramatsu M. Simultaneous measurement of superoxide generation and intracellular calcium ion of neutrophil-like culture cells. Luminescence 2006; 21: 69-71.
• 3 Kazumura K, Sato Y, Satozono H, et al. Simultaneous monitoring of superoxides and intracellular calcium ions in neutrophils by chemiluminescence and fluorescence: evaluation of action mechanisms of bioactive compounds in foods. J Pharm Biomed Anal 2013; 84: 90-96.
• 4 Bréchard S, Tschirhart EJ. Regulation of superoxide production in neutrophils: role of calcium influx. J Leukoc Biol 2008; 84: 1223-1237.
• 5 Foyouzi-Youssefi R, Petersson F, Lew DP, Krause KH, Nüsse O. Chemoattractant-induced respiratory burst: increases in cytosolic Ca²⁺ concentrations are essential and synergize with a kinetically distinct second signal. Biochem J 1997; 322: 709-718.

Terms in the title (5)： 細胞 ,  シコニン ,  好中球 ,  スーパーオキシド ,  阻害