Art

J-GLOBAL ID：201602287553129216   Reference number：16A1100515

Increased phosphorylation of ERK1/2 is associated with worse chemotherapeutic outcome and a poor prognosis in advanced lung adenocarcinoma

進行した肺腺がんにおいてERK1/2のリン酸化の上昇は化学治療の転帰の悪化と予後不良に関連する

Author (10)： Tsujino Ichiro (Division of Respiratory Medicine, Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan) ,  Nakanishi Yoko (Division of Pathology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan) ,  Hiranuma Hisato (Division of Respiratory Medicine, Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan) ,  Shimizu Tetsuo (Division of Respiratory Medicine, Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan) ,  Hirotani Yukari (Division of Pathology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan) ,  Ohni Sumie (Division of Pathology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan) ,  Ouchi Yasushi (Division of Respiratory Medicine, Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan) ,  Takahashi Noriaki (Division of Respiratory Medicine, Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan) ,  Nemoto Norimichi (Division of Pathology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan) ,  Hashimoto Shu (Division of Respiratory Medicine, Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan)
Material： Medical Molecular Morphology  (Med Mol Morphol)
Volume： 49  Issue： 2  Page： 98-109  Publication year： Jun. 2016 
JST Material Number： L1883A  ISSN： 1860-1480  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Thesaurus term： *Adenocarcinoma ,...
Semi thesaurus term： clinical outcome

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Author keywords (6)： Lung adenocarcinoma ,  EGFR ,  KRAS ,  pERK1/2 ,  Chemotherapy ,  Prognosis

JST classification (2)： Tumors(=neoplasms)of respiratory system  (GI04000G) ,  Clinical oncology in general  (GE03010Y)

Reference (49)：

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• Sato M, Shames DS, Gazdar AF, Minna JD (2007) A translational view of the molecular pathogenesis of lung cancer. J Thorac Oncol 2:327-343
• Pao W, Girard N (2011) New driver mutations in non-small-cell lung cancer. Lancet Oncol 12:175-180
• Chappell WH, Steelman LS, Long JM, Kempf RC, Abrams SL, Franklin RA, Bäsecke J, Stivala F, Donia M, Fagone P, Malaponte G, Mazzarino MC, Nicoletti F, Libra M, Maksimovic-Ivanic D, Mijatovic S, Montalto G, Cervello M, Laidler P, Milella M, Tafuri A, Bonati A, Evangelisti C, Cocco L, Martelli AM, McCubrey JA (2011) Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR inhibitors: rationale and importance to inhibiting these pathways in human health. Oncotarget 2:135-164

Terms in the title (7)： 肺腺がん ,  ERK1 ,  リン酸化 ,  化学治療 ,  転帰 ,  悪化 ,  予後不良