Art

J-GLOBAL ID：201602287918060429   Reference number：16A1305144

The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

抗体aducanumabはアルツハイマー病でAβ斑を減少させる

Author (30)： SEVIGNY Jeff (Biogen, Massachusetts, USA) ,  CHIAO Ping (Biogen, Massachusetts, USA) ,  BUSSIERE Thierry (Biogen, Massachusetts, USA) ,  WEINREB Paul H. (Biogen, Massachusetts, USA) ,  WILLIAMS Leslie (Biogen, Massachusetts, USA) ,  DUNSTAN Robert (Biogen, Massachusetts, USA) ,  CHEN Tianle (Biogen, Massachusetts, USA) ,  LING Yan (Biogen, Massachusetts, USA) ,  O'GORMAN John (Biogen, Massachusetts, USA) ,  QIAN Fang (Biogen, Massachusetts, USA) ,  ARASTU Mahin (Biogen, Massachusetts, USA) ,  LI Mingwei (Biogen, Massachusetts, USA) ,  CHOLLATE Sowmya (Biogen, Massachusetts, USA) ,  BRENNAN Melanie S. (Biogen, Massachusetts, USA) ,  QUINTERO-MONZON Omar (Biogen, Massachusetts, USA) ,  SCANNEVIN Robert H. (Biogen, Massachusetts, USA) ,  ARNOLD H. Moore (Biogen, Massachusetts, USA) ,  ENGBER Thomas (Biogen, Massachusetts, USA) ,  RHODES Kenneth (Biogen, Massachusetts, USA) ,  FERRERO James (Biogen, Massachusetts, USA) ,  HANG Yaming (Biogen, Massachusetts, USA) ,  MIKULSKIS Alvydas (Biogen, Massachusetts, USA) ,  SANDROCK Alfred (Biogen, Massachusetts, USA) ,  MAIER Marcel (Neurimmune, Schlieren-Zurich, CHE) ,  GRIMM Jan (Neurimmune, Schlieren-Zurich, CHE) ,  HOCK Christoph (Neurimmune, Schlieren-Zurich, CHE) ,  NITSCH Roger M. (Neurimmune, Schlieren-Zurich, CHE) ,  SALLOWAY Stephen (Butler Hospital, Rhode Island, USA) ,  HOCK Christoph (Univ. Zurich, Zurich, CHE) ,  NITSCH Roger M. (Univ. Zurich, Zurich, CHE)
Material： Nature (London)  (Nature (Lond))
Volume： 537  Issue： 7618  Page： 50-56  Publication year： Sep. 01, 2016 
JST Material Number： D0193B  ISSN： 0028-0836  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： *Alzheimer disease ,  transgenic mouse ,  experimental disease ,  *amyloid beta-protein ,  pathophysiology ,  human(primates) ,  *monoclonal antibody ,  *molecular targeting drug ,  *anti-Alzheimer's disease drug ,  dependence ,  criterion ,  neuropsychological test ,  phase 3 study
Semi thesaurus term： Humanized monoclonal antibody ,  *アデュカヌマブ ,  dosage dependence ,  投与期間依存性 ,  CDR-SB ,  mini-mental state examination

JST classification (2)： Basic research of other drugs acting on central nervous system  (GW03120U) ,  Drug therapy(=pharmacotherapy)for nervous system diseases  (GN05020Y)

Terms in the title (3)： 抗体 ,  アルツハイマー病 ,  斑