Art

J-GLOBAL ID：201602289741564398   Reference number：16A1037674

2-(4-Fluorophenyl)-quinazolin-4(3H)-one as a novel tyrosinase inhibitor: Synthesis, inhibitory activity, and mechanism

新規チロシナーゼ阻害剤2-(4-フルオロフェニル)-キナゾリン-4(3H)-オン:合成,阻害活性および反応機構

Author (8)： Wang Rui (Key Laboratory of Small Fuctional Organic Molecule, Ministry of Education and College of Life Science, Jiangxi Normal University, Nanchang, Jiangxi 330022, China) ,  Chai Wei-Ming (Key Laboratory of Small Fuctional Organic Molecule, Ministry of Education and College of Life Science, Jiangxi Normal University, Nanchang, Jiangxi 330022, China) ,  Chai Wei-Ming (Key Laboratory of Green Chemistry, Nanchang, Jiangxi 330022, China) ,  Yang Qin (Key Laboratory of Small Fuctional Organic Molecule, Ministry of Education and College of Life Science, Jiangxi Normal University, Nanchang, Jiangxi 330022, China) ,  Yang Qin (Key Laboratory of Green Chemistry, Nanchang, Jiangxi 330022, China) ,  Wei Man-Kun (Key Laboratory of Small Fuctional Organic Molecule, Ministry of Education and College of Life Science, Jiangxi Normal University, Nanchang, Jiangxi 330022, China) ,  Peng Yiyuan (Key Laboratory of Small Fuctional Organic Molecule, Ministry of Education and College of Life Science, Jiangxi Normal University, Nanchang, Jiangxi 330022, China) ,  Peng Yiyuan (Key Laboratory of Green Chemistry, Nanchang, Jiangxi 330022, China)
Material： Bioorganic & Medicinal Chemistry  (Bioorganic and Medicinal Chemistry)
Volume： 24  Issue： 19  Page： 4620-4625  Publication year： Oct. 01, 2016 
JST Material Number： W0556A  ISSN： 0968-0896  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： *enzyme inhibitor ,  *nitrogen heterocyclic compound ,  *polynuclear aromatic compound ,  *aromatic fluorine compound ,  chemical synthesis ,  structure analysis ,  mass spectrometry ,  FTIR spectroscopy ,  NMR ,  *catechol oxidase ,  docking ,  molecular recognition ,  mass transfer ,  fluorescence spectroscopy ,  amino acid ,  catecholamine ,  primary amine ,  phenolic compound
Semi thesaurus term： HRMS(spectrometry) ,  *quinazolines ,  mass transfer rate ,  molecular docking

Author keywords (5)： Quinazolinone ,  Synthesis ,  Tyrosinase inhibitor ,  Fluorescence ,  Molecular docking

JST classification (2)： Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W) ,  Pyrimidines  (CF07103W)

Substance index (3)： L-Dopa ,  Tyrosine ,  2-(4-Fluorophenyl)quinazoline-4(3H)-one

Terms in the title (3)： チロシナーゼ阻害剤 ,  キナゾリン ,  阻害活性