Art

J-GLOBAL ID：201602293821614631   Reference number：16A1176016

Transplantation of dental pulp stem cells suppressed inflammation in sciatic nerves by promoting macrophage polarization towards anti-inflammation phenotypes and ameliorated diabetic polyneuropathy

歯髄幹細胞の移植は抗炎症表現型へのマクロファージの分化を促進し,糖尿病性多発神経障害を改善することによって坐骨神経における炎症を抑制した

Author (12)： Omi Maiko (Department of Removable Prosthodontics, School of Dentistry, Aichi Gakuin University, Nagoya, Japan) ,  Hata Masaki (Department of Removable Prosthodontics, School of Dentistry, Aichi Gakuin University, Nagoya, Japan) ,  Nakamura Nobuhisa (Department of Internal Medicine, School of Dentistry, Aichi Gakuin University, Nagoya, Japan) ,  Miyabe Megumi (Department of Internal Medicine, School of Dentistry, Aichi Gakuin University, Nagoya, Japan) ,  Kobayashi Yasuko (Department of Internal Medicine, School of Dentistry, Aichi Gakuin University, Nagoya, Japan) ,  Kamiya Hideki (Division of Diabetes, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute, Japan) ,  Nakamura Jiro (Division of Diabetes, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute, Japan) ,  Ozawa Shogo (Department of Removable Prosthodontics, School of Dentistry, Aichi Gakuin University, Nagoya, Japan) ,  Tanaka Yoshinobu (Department of Removable Prosthodontics, School of Dentistry, Aichi Gakuin University, Nagoya, Japan) ,  Takebe Jun (Department of Removable Prosthodontics, School of Dentistry, Aichi Gakuin University, Nagoya, Japan) ,  Matsubara Tatsuaki (Department of Internal Medicine, School of Dentistry, Aichi Gakuin University, Nagoya, Japan) ,  Naruse Keiko (Department of Internal Medicine, School of Dentistry, Aichi Gakuin University, Nagoya, Japan)
Material： Journal of Diabetes Investigation (Web)  (JDI (Web))
Volume： 7  Issue： 4  Page： 485-496  Publication year： 2016 
JST Material Number： U0507A  ISSN： 2040-1124  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： rat ,...
Semi thesaurus term： CD206 antigen ,...

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Author keywords (3)： Cell transplantation ,  Dental pulp stem cells ,  Diabetic polyneuropathy

JST classification (3)： Metabolic diseases,nutritional diseases in general.  (GD05010J) ,  Basic neurology  (GN01020W) ,  Biophylaxis and immune systems in general  (ED01010F)

Reference (42)：

• Tesfaye S. Recent advances in the management of diabetic symmetrical polyneuropathy. J Diabetes Investig 2010; 2: 33-42.
• Naruse K, Hamada Y, Nakashima E, et al. Therapeutic neovascularization using cord blood-derived endothelial progenitor cells for diabetic neuropathy. Diabetes 2005; 54: 1823-1828.
• Naruse K, Sato J, Funakubo M, et al. Transplantation of bone marrow-derived mononuclear cells improves mechanical hyperalgesia, cold allodynia and nerve function in diabetic neuropathy. PLoS One 2011; 6: e27458.
• Shibata T, Naruse K, Kamiya H, et al. Transplantation of bone marrow-derived mesenchymal stem cells improves diabetic polyneuropathy in rats. Diabetes 2008; 57: 3099-3107.
• Himeno T, Kamiya H, Naruse K, et al. Angioblast derived from ES cells construct blood vessels and ameliorate diabetic polyneuropathy in mice. J Diabetes Res 2015; 2015: 257230.

Terms in the title (10)： 歯髄幹細胞 ,  移植 ,  抗炎症 ,  表現型 ,  マクロファージ ,  分化 ,  促進 ,  糖尿病性多発神経障害 ,  坐骨神経 ,  炎症