Pat

J-GLOBAL ID：201603011043111046

T細胞の分化誘導方法、T細胞の製造方法、T細胞、医薬組成物、及び、スクリーニング方法

Inventor： 菅井 学 ,  清水 章 ,  南部 由希子
Applicant, Patent owner： 国立大学法人京都大学
Agent (1)： 特許業務法人池内・佐藤アンドパートナーズ
Gazette classification：特許公報
Application number (International application number)：2014512405
Patent number：5900865
Application date： Mar. 12, 2013
Claim (excerpt)：

【請求項1】 CD4+CD8- T細胞をIL-2、TGF-β1、及びatRAが存在する条件下でin vitro培養することを含む、CD4+CD8- T細胞からCD4-CD8αα+ T細胞を分化誘導する方法。

IPC (6)：

C12N 5/0783 ( 201 0.01) ,  C12Q 1/02 ( 200 6.01) ,  A61K 35/14 ( 201 5.01) ,  A61P 37/06 ( 200 6.01) ,  A61P 35/00 ( 200 6.01) ,  A61P 31/12 ( 200 6.01)

FI (6)：

C12N 5/078 ,  C12Q 1/02 ,  A61K 35/14 Z ,  A61P 37/06 ,  A61P 35/00 ,  A61P 31/12

Article cited by the Patent：

Cited by applicant (8)

• PHENOTYPICAL AND FUNCTIONAL CHARACTERIZATION OF SMALL INTESTINAL TCR-GAMMA-DELTA-POSITIVE T CELLS IN
• Development of .GAMMA..DELTA. thymocyte subsets during prenatal and postnatal ontogeny
• Anti-TCR antibody treatment activates a novel population of nonintestinal CD8 alpha alpha+TCR alpha
• Isolation of a CD8alphaalpha+ CD4- tumour T-cell clone with cytotoxic activity from a CD4+ CD8- cuta
• CD4(-)CD8alphaalpha subset of CD1d-restricted NKT cells controls T cell expansion.
• Functionally mature CD4 and CD8 TCRalphabeta cells are generated in OP9-DL1 cultures from human CD34
• CD4+ Foxp3+ regulatory T cells induced by TGF-β, IL-2 and all-trans retinoic acid attenuate obliter
• Control of the development of CD8αα+ intestinal intraepithelial lymphocytes by TGF-β.

Cited by examiner (8)

• PHENOTYPICAL AND FUNCTIONAL CHARACTERIZATION OF SMALL INTESTINAL TCR-GAMMA-DELTA-POSITIVE T CELLS IN
• Development of .GAMMA..DELTA. thymocyte subsets during prenatal and postnatal ontogeny
• Anti-TCR antibody treatment activates a novel population of nonintestinal CD8 alpha alpha+TCR alpha
• Isolation of a CD8alphaalpha+ CD4- tumour T-cell clone with cytotoxic activity from a CD4+ CD8- cuta
• CD4(-)CD8alphaalpha subset of CD1d-restricted NKT cells controls T cell expansion.
• Functionally mature CD4 and CD8 TCRalphabeta cells are generated in OP9-DL1 cultures from human CD34
• CD4+ Foxp3+ regulatory T cells induced by TGF-β, IL-2 and all-trans retinoic acid attenuate obliter
• Control of the development of CD8αα+ intestinal intraepithelial lymphocytes by TGF-β.