J-GLOBAL ID:201610002262434622   Research Resource code:NBDC01620 Update date:Sep. 26, 2016

CPLM: Compendium of Protein Lysine Modifications

CPLM: Compendium of Protein Lysine Modifications
Owning Organization:
  • The CUCKOO Workgroup
Resource classification: Database
Tag (subject)  (1): Protein
Tag (data type)  (2): Sequence ,  Bibliography/Documents
Species (12): Homo sapiens (NCBI Taxonomy ID: 9606) ,  Mus musculus (NCBI Taxonomy ID: 10090) ,  Rattus norvegicus (NCBI Taxonomy ID: 10116) ,  Cavia porcellus (NCBI Taxonomy ID: 10141) ,  Plasmodium falciparum (NCBI Taxonomy ID: 5833) ,  Toxoplasma gondii (NCBI Taxonomy ID: 5811) ,  Drosophila melanogaster (NCBI Taxonomy ID: 7227) ,  Saccharomyces cerevisiae (NCBI Taxonomy ID: 4932) ,  Arabidopsis thaliana (NCBI Taxonomy ID: 3702) ,  Escherichia coli (NCBI Taxonomy ID: 562) ,  Mycoplasma pneumoniae (NCBI Taxonomy ID: 2104) ,  Rhodopseudomonas palustris (NCBI Taxonomy ID: 1076)
CPLA is a compendium database for lysine acetylated substrates. It contains 3,311 unique protein entries with 7,151 experimentally identified lysine acetylation sites, that were manually collected from the scientific literature. The regulatory roles of lysine acetylation were statistically analyzed with the gene Ontology (GO) and InterPro annotations.

Combinations with protein-protein interaction information are systematically discovered a potential human lysine acetylation network (HLAN) among histone acetyltransferases (HATs), substrates and histone deacetylases (HDACs). There are 1862 triplet relationships of HAT-substrate-HDAC retrieved from the HLAN, at least 13 of which were previously experimentally verified.
Source: NBDC
Record maintainer: Integbio Database Catalog
Record license: Creative Commons CC0 license

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