Hayashi Yoshinori

Affiliation and department：
Homepage URL (1)： http://www2.dent.nihon-u.ac.jp/g.physiology/index.html

Research field (4)： Surgical dentistry , Oral medicine , Neuropathology , Neuroscience - general

Research keywords (9)：線維芽細胞 , マクロファージ , シュワン細胞 , カテプシン , 末梢神経再生 , 三叉神経節 , 三叉神経 , グリア , 疼痛

Research theme for competitive and other funds (11)：

2023 - 2028 Novel molecular mechanism of oral cancer pain focused attention on plastic changes in intercellular network in the trigeminal ganglion
2023 - 2026 三叉神経節ニューロンの新たな可塑性の獲得様式の同定による神経障害性疼痛の解明
2022 - 2025 Fundamental study of the development of new therapy for the treatment of anticancer drug-induced persistent pain targeting glial cell activation
2021 - 2024 Orofacial pain mechanism due to infant stress
2020 - 2023 投射ニューロンにおける新たな疼痛マーカーの発見とその分子制御による鎮痛法の確立

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Papers (80)：

Yousuke Ikehata, Eri Oshima, Yoshinori Hayashi, Yukinori Tanaka, Hitoshi Sato, Suzuro Hitomi, Miho Shiratori-Hayashi, Kentaro Urata, Yuki Kimura, Ikuko Shibuta, et al. Fibroblast-derived IL-33 exacerbates orofacial neuropathic pain via the activation of TRPA1 in trigeminal ganglion neurons. Brain, Behavior, and Immunity. 2024
Kentaro Urata, Tatsuki Oto, Yoshinori Hayashi, Suzuro Hitomi, Takayuki Ikeda, Koichi Iwata, Toshimitsu Iinuma, Masamichi Shinoda. Ageing-Related Macrophage Polarisation in the Trigeminal Ganglion Enhances Incisional Intraoral Pain. Oral Diseases. 2024
Koichi Iwata, Yoshinori Hayashi, Suzuro Hitomi, Yoshiyuki Tsuboi, Masamichi Shinoda. Non-neuronal cells act as crucial players in neuropathic orofacial pain. Journal of Oral Biosciences. 2024
Chihiro Soma, Suzuro Hitomi, Eri Oshima, Yoshinori Hayashi, Kumi Soma, Ikuko Shibuta, Yoshiyuki Tsuboi, Tetsuo Shirakawa, Takashi Kikuiri, Koichi Iwata, et al. Involvement of oxidative stress in orofacial mechanical pain hypersensitivity following neonatal maternal separation in rats. Scientific reports. 2023. 13. 1. 22760-22760
Masato Iida, Suzuro Hitomi, Yoshinori Hayashi, Ikuko Shibuta, Yoshiyuki Tsuboi, Koichiro Ueda, Koichi Iwata, Masamichi Shinoda. Analgesic effect of linalool odor on oral ulcerative mucositis-induced pain in rats. Brain research bulletin. 2023. 206. 110844-110844

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MISC (17)：

岡田明子, 淺野早哉香, 篠田雅路, 林良憲, 岩田幸一, 今村佳樹. Involvement of IFN-γ in activated glial cells in orofacial neuropathic pain. Pain Research. 2020. 35. 4
林良憲, 中西博. ミクログリア特異的BK チャネルの活性化がモルヒネ誘発性痛覚過敏を引き起こす. 実験医学 CURRENT TOPICS. 2016
Microglia-mediated adverse effects of opioid and their possible solutions. 2016. 48. 8. 365-368
Yoshinori Hayashi, Saoru Koyanagi, Naoki Kusunose, Ryo Okada, Zhou Wu, Hidetoshi Saitoh, Shinichi Kohsaka, Kazuhide Inoue, Shigehiro Ohodo, Hiroshi Nakanishi. Regulation of synaptic strength are controlled by circadian rhythm of cathepsin S expression in the microglia. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2014. 124. 125P-125P
Xinwen Zhang, Zhou Wu, Yoshinori Hayashi, Hiroshi Nakanishi. Involvement of Th1 cells in the transition of nerve injury-induced acute pain to a chronic state. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2014. 124. 82P-82P

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Lectures and oral presentations (11)：

Neutrophil-neuron crosstalk induces mechanical allodynia in experimental autoimmune encephalomyelitis
(2021)
神経と免疫の双方向性作用に基づいた痛みの発症メカニズム
(日本薬理学会次世代薬理学セミナー2019 in 那覇 2019)
ミクログリアのchannelopathyがもたらす痛みの慢性化機構の解明
(第24回日本口腔顔面痛学会学術大会 2019)
実験的自己免疫性脳脊髄炎におけるカテプシンEがもたらす免疫感覚異常
(第2回感覚免疫学研究会 2018)
痛みの慢性化スイッチとしてのケラチノサイトの新たな役割
(第59回歯科基礎医学会学術大会アップデートシンポジウム 2017)

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Education (3)：

2006 - 2010 Kyushu University
2004 - 2006 Kyushu University
2000 - 2004 Kyushu University School of Pharmaceutical Sciences

Professional career (1)：

学術 (九州大学)

Work history (6)：

2020/10 - 現在 Nihon University School of Dentistry
2023/06 - 2024/02 The University of Alabama at Birmingham Department of Anesthesiology Research Scholar
2019/04 - 2020/09 Nihon University School of Dentistry
2016/06 - 2019/03 Kyushu University School of Dentistry
2010/04 - 2016/05 Kyushu University School of Dentistry

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Committee career (8)：

2023/04 - 現在日本薬理学会代議員
2022/04 - 現在歯科基礎医学会代議員
2020/10 - 現在日大歯学会評議員
2020/04 - 現在日本口腔顔面痛学会ポスター賞推薦委員会
2020/04 - 現在日本口腔顔面痛学会ガイドライン作成委員会

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Awards (8)：

2019/12 - 8th Asian Pain Symposium Outstanding Research Award
2014/09 - 第56回歯科基礎医学会第26回歯科基礎医学会賞
2012/06 - Purine 2012 Purine 2012 Poster Award
2011/10 - 歯科基礎医学会第53回歯科基礎医学会学術大会・総会優秀ポスター発表賞
2010/10 - 内藤記念科学振興財団第29回内藤コンファレンス Poster Award

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Association Membership(s) (5)：

JAPANESE ASSOCIATION FOR THE STUDY OF PAIN , Society for Neuroscience , JAPANESE ASSOCIATION FOR ORAL BIOLOGY , THE JAPANESE PHARMACOLOGICAL SOCIETY , 日本口腔顔面痛学会

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