Rchr
J-GLOBAL ID：201701002083468177
Update date: Nov. 18, 2024
Watabe Tetsuro
ワタベ テツロウ | Watabe Tetsuro
Affiliation and department：
Homepage URL (1)：
http://cellular-biochemistry-tmdu.net/
Research field (3)：
Oral medicine
, Tumor biology
, Pathobiochemistry
Research keywords (5)：
BMP
, TGF-β
, lymphangiogenesis
, angiogenesis
, cancer
Research theme for competitive and other funds (22)：
- 2020 - 2023 シングルセル解析による口腔がんの増殖と運動・転移を司るメカニズムの解明
- 2017 - 2020 Radiosenstizing mechanism by immune modifications: elucidation from tumor cell kinetics
- 2017 - 2020 Exosomes promoting malignancy and affecting tumor microenvironment, the target for anti-tumor therapy.
- 2016 - 2019 Cellular dynamics and molecular mechanism on lymphatic network formation in artificial three-dimensional human tissue
- 2016 - 2019 Molecular mechanisms of the endothelial-to-mesenchymal transition of lymphatic endothelial cells
- 2016 - 2019 Challenge to the RNA nucleotide medicine using the mechanism of GPCR network pathway for bone regeneration.
- 2014 - 2017 Basic research on novel oncolytic virus therapy targeting glioma initiating cells
- 2013 - 2017 Establishment of induced lymphatic endothelial cells by direct reprogramming
- 2010 - 2016 Effects of TGF-beta family on cancer microenvironment and strategies for cancer therapy
- 2013 - 2015 リンパ管-血管-神経ネットワークの形成における相互作用の役割
- 2011 - 2013 リンパ管-血管-神経ネットワークの形成における相互作用の役割
- 2010 - 2012 Study of the molecular mechanisms underlying endothelilal-to mesenchymal transition which promotes cancer progression
- 2007 - 2009 Mechanisms for regulation of lymphangiogenesis
- 2005 - 2009 Establishment of New Strategies for Treatment of Cancer Using TGF-beta Signaling
- 2007 - 2008 Regulation of Prox1-mediated lymphatic differentiation ofendothelial cells by transcriptional regulators
- 2005 - 2006 ES細胞由来のリンパ管内皮前駆細胞への分化誘導因子の同定
- 2005 - 2006 Mechanisms of lymphatic differentiation from mouse embryonic stem cells
- 2004 - 2005 マウス発生過程における血管内皮細胞のダイナミクス
- 2003 - 2004 Molecular mechanism of vascular endothelial/mural cell differentiation by receptor tyrosine kinases
- 2003 - 2004 胚性幹(ES)細胞から血管内皮細胞への分化におけるTGF-βシグナルの機能解析
- 2000 - 2004 Mechanisms of TGF-β signaling and its abnormalities in human cancer
- 2002 - 2003 マウス臓器形成におけるTGF-βスーパーファミリーの発現誘導機構を用いた機能解析
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Papers (100)：
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Tatsuro Seike, Kazue Terasawa, Takanori Iwata, Jun-Lin Guan, Tetsuro Watabe, Shigeyuki Yokoyama, Miki Hara-Yokoyama. Site-specific photo-crosslinking of Hsc70 with the KFERQ pentapeptide motif in a chaperone-mediated autophagy and microautophagy substrate in mammalian cells. Biochemical and biophysical research communications. 2024. 736. 150515-150515
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Haruka Ibi, Kazuki Takahashi, Hiroyuki Harada, Tetsuro Watabe, Katarzyna A Podyma-Inoue. Transforming growth factor-β signals promote progression of squamous cell carcinoma by inducing epithelial-mesenchymal transition and angiogenesis. Biochemical and biophysical research communications. 2024. 714. 149965-149965
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Haruko Watanabe-Takano, Katsuhiro Kato, Eri Oguri-Nakamura, Tomohiro Ishii, Koji Kobayashi, Takahisa Murata, Koichiro Tsujikawa, Takaki Miyata, Yoshiaki Kubota, Yasuyuki Hanada, et al. Endothelial cells regulate alveolar morphogenesis by constructing basement membranes acting as a scaffold for myofibroblasts. Nature communications. 2024. 15. 1. 1622-1622
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Yukinori Ikeda, Jun-ichi Suehiro, Hiroko Oshima, Sau Yee Kok, Kazuki Takahashi, Hiroyuki Sakurai, Tetsuro Watabe, Masanobu Oshima, Yukiko T. Matsunaga. Tumor-microvessel on-a-chip reveals sequential intravasation cascade of cancer cell clusters. 2024
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Hiroki Inoue, Taku Kanda, Gakuto Hayashi, Ryota Munenaga, Masayuki Yoshida, Kana Hasegawa, Takuya Miyagawa, Yukiya Kurumada, Jumpei Hasegawa, Tomoyuki Wada, et al. A MAP1B-cortactin-Tks5 axis regulates TNBC invasion and tumorigenesis. The Journal of cell biology. 2024. 223. 3
ｍore...
MISC (4)：
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Kazuki Takahashi, Yuichi Akatsu, Katarzyna A. Podyma-Inoue, Takehisa Matsumoto, Hitomi Takahashi, Yasuhiro Yoshimatsu, Daizo Koinuma, Mikako Shirouzu, Kohei Miyazono, Tetsuro Watabe. Targeting all transforming growth factor-b isoforms with an Fc chimeric receptor impairs tumor growth and angiogenesis of oral squamous cell cancer. Journal of Biological Chemistry. 2020. 295. 36. 12559-12572
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高橋 和樹, 井上 ポディマ, カタジナ アンナ, 高尾 千紘, 吉松 康裕, 村松 智輝, 稲澤 譲治, 渡部 徹郎. 口腔扁平上皮がん細胞HOC313-LMの運動能と腫瘍形成能の制御におけるトランスフォーミング増殖因子βシグナルの役割(Regulatory Role of Transforming Growth Factor-β Signals in the Migration and Tumor Formation of HOC313-LM cells, an Oral Squamous Cell Carcinoma). 口腔病学会雑誌. 2018. 85. 2. 52-61
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高橋 和樹, 井上 カタジナアンナ, 吉松 康裕, 戒田 篤志, 三浦 雅彦, 渡部 徹郎. 口腔がん細胞のTGF-βによる上皮間葉移行に伴う細胞周期制御の検討. 生命科学系学会合同年次大会. 2017. 2017年度. [1P-0995]
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山崎 智子, 末弘 淳一, 南 敬, 児玉 龍彦, 渡部 徹郎, 宮園 浩平. 新規COUP-TFIIスプライシング変異体によるCOUP-TFIIの転写調節(Regulation of COUP-TFll transcription by a novel COUP-TFII splicing variant). 日本生化学会大会プログラム・講演要旨集. 2011. 84回. 4T15a-3
Patents (15)：
Education (3)：
- - 1997 カリフォルニア大学アーヴァイン校(UCI) 生物科学系研究科 博士号(Ph.D.)取得
- - 1990 The University of Tokyo
- - 1988 The University of Tokyo
Professional career (1)：
Work history (8)：
- 2024/10 - 現在 Institute of Sciecne Tokyo Department of Biochemistry, Graduate School of Medical and Dental Sciences Professor
- 2021/04 - 2024/09 Tokyo Medical and Dental University Department of Biochemistry, Graduate School of Medical and Dental Sciences Professor
- 2015/07 - 2021/03 Tokyo Medical and Dental University Department of Biochemistry, Graduate School of Medical and Dental Sciences Professor
- 2013/07 - 2015/06 Tokyo University of Pharmacy and Life Sciences School of Life Science
- 2009/05 - 2013/06 The University of Tokyo Department of Molecular Pathology Associate Professor
- 2001/03 - 2009/04 The University of Tokyo Department of Molecular Pathology Assistant Professor
- 2000/12 - 2001/02 財団法人癌研究会癌研究所 生化学部 嘱託研究員
- 1997/04 - 2000/11 カリフォルニア大学ロサンゼルス校(UCLA) ハワードヒューズ医学研究所 研究員(ポスドク)
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Committee career (4)：
- 日本血管生物学会 理事・理事長
- 日本リンパ学会 常任理事・副理事長
- 日本癌学会 評議員
- 日本生化学会 評議員
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