Rchr
J-GLOBAL ID:201701002518138522
Update date: Feb. 01, 2024
Nobuyuki Fujiwara
Nobuyuki Fujiwara
Affiliation and department:
Research field (3):
Tumor biology
, Digestive surgery
, Veterinary medicine
Research keywords (3):
脂肪肝炎
, がん幹細胞
, シグナル伝達
Research theme for competitive and other funds (5):
- 2022 - 2025 Are distal airway "metaplastic cells" in feline idiopathic pulmonary fibrosis an indication of malignant transformation?
- 2021 - 2024 大腸がん幹細胞で発現上昇するPP6の制御を介した抗がん戦略の構築
- 2018 - 2021 Novel immunotherapy for pancreatic cancer by the multi-HLA binding peptides derived from cancer stemness molecules.
- 2018 - 2021 オートファジー活性制御を介した肝細胞がん幹細胞に対する治療法の開発
- 2015 - 2017 がん抑制因子Beclin 1の新規リン酸化サイトの役割の解明
Papers (18):
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Miu Yamamoto, Nobuyuki Fujiwara. Protein phosphatase 6 regulates trametinib sensitivity, a mitogen-activated protein kinase kinase (MEK) inhibitor, by regulating MEK1/2-ERK1/2 signaling in canine melanoma cells. The Journal of veterinary medical science. 2023
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Ryouichi Tsunedomi, Kiyoshi Yoshimura, Yuta Kimura, Mitsuo Nishiyama, Nobuyuki Fujiwara, Satoshi Matsukuma, Shinsuke Kanekiyo, Hiroto Matsui, Yoshitaro Shindo, Yusaku Watanabe, et al. Elevated expression of RAB3B plays important roles in chemoresistance and metastatic potential of hepatoma cells. BMC cancer. 2022. 22. 1. 260-260
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Naoki Kohyanagi, Nao Kitamura, Keiko Tanaka, Takuya Mizuno, Nobuyuki Fujiwara, Takashi Ohama, Koichi Sato. The protein level of the tumor-promoting factor SET is regulated by cell density. Journal of biochemistry. 2022. 171. 3. 295-303
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Nao Kitamura, Nobuyuki Fujiwara, Koji Hayakawa, Takashi Ohama, Koichi Sato. Protein phosphatase 6 promotes neurite outgrowth by promoting mTORC2 activity in N2a cells. Journal of biochemistry. 2021. 170. 1. 131-138
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Nobuyuki Fujiwara, Shusaku Shibutani, Takashi Ohama, Koichi Sato. Protein phosphatase 6 dissociates the Beclin 1/Vps34 complex and inhibits autophagy. Biochemical and biophysical research communications. 2021. 552. 191-195
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MISC (14):
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藤原信行, 藤原信行, 藤原信行, 恒富亮一, 硲彰一, 友近忍, 鈴木伸明, 大浜剛, 佐藤晃一, 永野浩昭. Protein phosphatase6は大腸癌細胞の幹細胞性を制御する. 日本獣医学会学術集会講演要旨集. 2020. 163rd
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藤原信行, 藤原信行, 藤原信行, 恒富亮一, 硲彰一, 鈴木伸明, 大浜剛, 吉野茂文, 永野浩昭. Protein phosphatase 6 controls tumor malignancy of colon cancer through regulation of cancer stemness. 日本癌学会学術総会抄録集(Web). 2019. 78th
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恒富 亮一, 吉村 清, 松隈 聰, 藤原 信行, 西山 光郎, 兼清 信介, 飯田 通久, 鈴木 伸明, 武田 茂, 吉野 茂文, et al. 肝細胞癌幹細胞様Sphere細胞における抗癌剤耐性に関わるRAB3B遺伝子(RAB3B gene was identified as a gene involved in chemoresistance of induced cancer stem-like sphere cells). 日本癌学会総会記事. 2018. 77回. 992-992
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藤原信行, 恒富亮一, 硲彰一, 友近忍, 鈴木伸明, 大浜剛, 佐藤晃一, 永野浩昭. Protein phosphatase6は大腸癌の悪性化に関与する. 日本分子生物学会年会プログラム・要旨集(Web). 2018. 41st
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藤原信行, 藤原信行, 渋谷周作, 坂井祐介, 島礼, 渡邊利雄, 大島浩子, 大島正伸, 齋藤達哉, 審良静男, et al. オートファジーによるtype2A protein phosphataseの制御機構の解明. 日本生化学会大会(Web). 2017. 90th
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Education (2):
- 2013 - 2017 Yamaguchi University The United Graduate School of Veterinary Sciences
- 2007 - 2013 Yamaguchi University Faculty of Agriculture Veterinary Medicine
Professional career (1):
Awards (3):
- 2019/07 - 日本プロテインホスファターゼ研究会 日本プロテインホスファターゼ研究会奨励賞 Protein phosphatase 6は大腸癌細胞の幹細胞性を制御する
- 2014/09 - 日本比較薬理毒性分科会 日本比較薬理学・毒性学会 奨励賞 イヌSETアイソフォームの同定とSET阻害ペプチドによる抗がん効果の検討
- 2014/02 - The Excellent Presentation Award Protein phosphatase 2A and Akt/PKB regulate Beclin1-Bcl-2 association and autophagy
Association Membership(s) (5):
日本ワンヘルスサイエンス学会
, 日本分子生物学会
, 日本獣医学会
, 日本癌学会
, 日本プロテインホスファターゼ研究会
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