Rchr
J-GLOBAL ID:201701003909515114   Update date: Jan. 20, 2021

Okanishi Hiroki

オカニシ ヒロキ | Okanishi Hiroki
Affiliation and department:
Research field  (1): Molecular biology
Research theme for competitive and other funds  (4):
  • 2020 - 2023 新規細胞内アミノ酸センサーの同定と分子機構解明および創薬標的としての可能性の探索
  • 2019 - 2022 輸送体と受容体を介するアミノ酸シグナリング機構の解明と代謝制御創薬の基盤の確立
  • 2019 - 2022 アミノ酸シグナル経路における輸送体LAT1下流の未知のリン酸化ネットワークの解明
  • 2018 - 2020 アミノ酸アベイラビリティの寿命に及ぼす影響とその分子基盤の解明
Papers (13):
  • Hiroki Okanishi, Ryuichi Ohgaki, Suguru Okuda, Hitoshi Endou, Yoshikatsu Kanai. Proteomics and phosphoproteomics reveal key regulators associated with cytostatic effect of amino acid transporter LAT1 inhibitor. Cancer science. 2020
  • Chunhuan Jin, Ling Wei, Ryuichi Ohgaki, Hideyuki Tominaga, Minhui Xu, Suguru Okuda, Hiroki Okanishi, Yasuharu Kawamoto, Xin He, Shushi Nagamori, et al. Interaction of Halogenated Tyrosine/Phenylalanine Derivatives with Organic Anion Transporter 1 in the Renal Handling of Tumor Imaging Probes. The Journal of pharmacology and experimental therapeutics. 2020. 375. 3. 451-462
  • Lili Quan, Ryuichi Ohgaki, Saori Hara, Suguru Okuda, Ling Wei, Hiroki Okanishi, Shushi Nagamori, Hitoshi Endou, Yoshikatsu Kanai. Amino acid transporter LAT1 in tumor-associated vascular endothelium promotes angiogenesis by regulating cell proliferation and VEGF-A-dependent mTORC1 activation. Journal of experimental & clinical cancer research : CR. 2020. 39. 1. 266-266
  • Yusuke Fujino, Takero Miyagawa, Masayuki Torii, Masao Inoue, Yuki Fujii, Hiroki Okanishi, Yoshikatsu Kanai, Ryoji Masui. Structural changes induced by ligand binding drastically increase the thermostability of the Ser/Thr protein kinase TpkD from Thermus thermophilus HB8. FEBS letters. 2020
  • Daiki Kobayashi, Takaho Tokuda, Kyosuke Sato, Hiroki Okanishi, Megumi Nagayama, Mio Hirayama-Kurogi, Sumio Ohtsuki, Norie Araki. Identification of a Specific Translational Machinery via TCTP-EF1A2 Interaction Regulating NF1-associated Tumor Growth by Affinity Purification and Data-independent Mass Spectrometry Acquisition (AP-DIA). Molecular & cellular proteomics : MCP. 2019. 18. 2. 245-262
more...
MISC (9):
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Lectures and oral presentations  (4):
  • Proteomics of post-translational lysine acetylation in glioma-derived stem cells
    (16th Human Proteome Organization World Congress 2017 2017)
  • Lysine propionylation is a novel post-translational modification occurring on many bacterial proteins
    (8th Asia Oceania Human Proteome Organization 2016)
  • A novel post-translational modification: lysine propionylation was identified in bacterial species
    (15th Human Proteome Organization World Congress 2016 2016)
  • Structural insights of protein acetylation sites in the proteome of Thermus thermophilus
    (Bilateral NTHU-OU Life Science Conference 2014 2014)
Education (3):
  • 2013 - 2016 Osaka University Department of Biological Sciences, PhD course
  • 2011 - 2013 Osaka University Department of Biological Sciences, MS course
  • 2007 - 2011 Osaka University Department of Biological Sciences
Professional career (1):
  • 博士(理学) (大阪大学)
Work history (4):
  • 2018/04 - 現在 Osaka University Graduate School of Medicine
  • 2016/06 - 2018/03 Kumamoto University Faculty of Life Sciences
  • 2016/05 - 2017/03 Osaka University Graduate School of Science
  • 2016/04 - 2016/05 Osaka City University Graduate School of Science
Awards (3):
  • 2016/12 - 日本分子生物学会 第39回日本分子生物学会年会 優秀ポスター賞 バクテリアにおける翻訳後修飾アシル化プロテオミクス
  • 2015/12 - モデル生物丸ごと一匹学会 第5回モデル生物学会 優秀発表賞 Proteome-wide analysis showed the abundance of lysine propionylation and its physiological significance
  • 2014/06 - 日本蛋白質科学会 第14回日本蛋白質科学会年会 ポスター賞 高度好熱菌Thermus thermophilus HB8におけるオミクス的解析: アセチル化プロテオーム解析
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