2022 - 2025 New mechanisms of sublingual immunotherapy for the treatment of allergic rhinitis
2019 - 2022 Development of new diagnostic methods by extracellular vesicles in nasal lavage fluids
2018 - 2021 Role of innate immunity in the pathogenesis of eosinophilic chronic rhinosinusitis: Alermin and IL-18
2016 - 2019 Elucidation of the pathophysiology of eosinophilic chronic rhinosinusitis focusing on the action of coagulation factors on fibroblasts and eosinophils
2014 - 2017 Tissue remodering of eosinophilic chronic rhinosinusitis
2014 - 2016 Determinations of nasal biomarkers for dementia and development of a novel diagnostic method for Alzheimer's disease using nasal samples.
2013 - 2016 Development of the method of measurement of amyloid-beta in nasal samples for diagnosis of Alzheimer's Disease
2011 - 2013 Eosinophil-epithelial cell interactions stimulate the production of MUC5AC mucin and profibrotic cytokines involved in airway tissue remodeling
2010 - 2012 Role of coagulation factors in the eosinophilic inflammation of upper airways
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Papers (62):
Kento Kawakita, Hideaki Kouzaki, Takuya Murao, Yoshihito Kubo, Tatsuji Nishiguchi, Keigo Nakamura, Hiroyuki Arai, Koji Matsumoto, Ichiro Tojima, Shino Shimizu, et al. Role of basal cells in nasal polyp epithelium in the pathophysiology of eosinophilic chronic rhinosinusitis (eCRS). Allergology international : official journal of the Japanese Society of Allergology. 2024. 73. 4. 563-572
Shino Shimizu, Misako Nakayama, Cong Thanh Nguyen, Hirohito Ishigaki, Yoshinori Kitagawa, Fumihiko Yasui, Yoshiki Yagi, Tomoe Kusayanagi, Michinori Kohara, Yasushi Itoh, et al. SARS-CoV-2 induces inflammation and intracranial infection through the olfactory epithelium-olfactory bulb pathway in non-human primates. Journal of Neuroimmunology. 2024. 578288-578288
Keigo Nakamura, Hideaki Kouzaki, Takuya Murao, Kento Kawakita, Hiroyuki Arai, Koji Matsumoto, Yoshihito Kubo, Ichiro Tojima, Shino Shimizu, Yukiko Ogawa, et al. Sublingual immunotherapy decreases the avidity of antigen-specific IgE in patients with Japanese cedar pollinosis. Allergy. 2023
Takuya Murao, Hideaki Kouzaki, Hiroyuki Arai, Koji Matsumoto, Keigo Nakamura, Kento Kawakita, Ichiro Tojima, Shino Shimizu, Atsushi Yuta, Takeshi Shimizu. Increase in the prevalence of follicular regulatory T cells correlates with clinical efficacy of sublingual immunotherapy with house dust mites. International forum of allergy & rhinology. 2023
1997 - 2001 Mie University Graduate School of medicine
1989 - 1995 Mie University Faculty of Medcine Medical course
Work history (7):
2010/04 - 現在 Shiga University of Medical Science Department of Otorhinolaryngology
2008/04 - 2010/03 Shiga University of Medical Science Department of Otorhinolaryngology
2007/06 - 2010/03 Shiga University of Medical Science Department of Otorhinolaryngology
2003/12 - 2004/02 Mie University Hospital Department of Otorhinolaryngology
2001/04 - 2003/11 Mie University Hospital Department of Otorhinolaryngology
1996/10 - 1998/03 National Tsu Hospital Department of Otorhinolaryngology
1995/05 - 1996/09 Mie University Hospital Department of Otorhinolaryngology
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Awards (1):
2009/10 - 日本鼻科学会 第16回日本鼻科学会賞
Association Membership(s) (5):
JAPAN SOCIETY OF IMMUNOLOGY AND ALLERGOLOGY IN OTOLARYNGOLOGY
, JAPANESE SOCIETY OF ALLERGOLOGY
, THE JAPANESE RHINOLOGIC SOCIETY
, THE OTO-RHINO-LARYNGOLOGICAL SOCIETY OF JAPAN
, 日本めまい平衡医学会