Shinoda Yasuharu

シノダヤスハル | Shinoda Yasuharu

Affiliation and department：

Research field (3)： Neuroscience - general , Pharmaceuticals - health and biochemistry , Pharmacology

Research keywords (6)：脂肪酸結合タンパク質 , シグマ1受容体 , プロテインホスファタ-ゼ , 神経変性疾患 , 精神疾患 , 循環器疾患

Research theme for competitive and other funds (6)：

2024 - 2027 ミクログリアサブセット制御異常に基づく複合性局所疼痛症候群発症機序の解明
2023 - 2026 マクロファージNCX1輸送制御に基づく血管新生機序の解明
2022 - 2025 遠位尿細管特異的遺伝子改変マウスを駆使した急性腎障害機序の解明
2020 - 2023 シグマ1受容体変異を伴う筋萎縮性側索硬化症の病態解明と創薬
2019 - 2022 Development of Therapeutics for Mitochondrial Impairment in Autism Spectrum Disorders

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Papers (33)：

Shiho Shibata, Hideaki Tagashira, Takayuki Nemoto, Satomi Kita, Tomo Kita, Yasuharu Shinoda, Kouzaburo Akiyoshi, Ken Yamaura, Takahiro Iwamoto. Perineural treatment with anti-TNF-α antibody ameliorates persistent allodynia and edema in novel mouse models with complex regional pain syndrome. Journal of pharmacological sciences. 2023. 153. 1. 1-11
Nemoto T., Gotoh Y., Kuwahara M., Kita T., Shinoda Y., Kita S., Iwamoto T. YM-244769, a highly potent Na+/Ca2+ exchange inhibitor, efficiently protects renal ischemia-reperfusion injury mice. JJSMgR. 2023. 41. 2. 66-72
Hideaki Tagashira, Md Shenuarin Bhuiyan, Yasuharu Shinoda, Ichiro Kawahata, Tomohiro Numata, Kohji Fukunaga. Sigma-1 receptor is involved in modification of ER-mitochondria proximity and Ca2+ homeostasis in cardiomyocytes. Journal of pharmacological sciences. 2023. 151. 2. 128-133
Kazuya Matsuo, Yasuharu Shinoda, Nona Abolhassani, Yusaku Nakabeppu, Kohji Fukunaga. Transcriptome Analysis in Hippocampus of Rats Prenatally Exposed to Valproic Acid and Effects of Intranasal Treatment of Oxytocin. Frontiers in psychiatry. 2022. 13. 859198-859198
An Cheng, Yi-Fei Wang, Yasuharu Shinoda, Ichiro Kawahata, Tetsunori Yamamoto, Wen-Bin Jia, Hanae Yamamoto, Tomohiro Mizobata, Yasushi Kawata, Kohji Fukunaga. Fatty acid-binding protein 7 triggers α-synuclein oligomerization in glial cells and oligodendrocytes associated with oxidative stress. Acta pharmacologica Sinica. 2021. 43. 3. 552-562

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MISC (4)：

Shinoda Y., Nemoto T., Iwamoto T. Pathophysiological Roles and Therapeutic Potential in Neurodegenerative Diseases. Med Bullet Fukuoka Univ. 2023. 50. 1. 43-48
Kohji Fukunaga, Hisanao Izumi, Yasushi Yabuki, Yasuharu Shinoda, Norifumi Shioda, Feng Han. Alzheimer's disease therapeutic candidate SAK3 is an enhancer of T-type calcium channels. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2019. 139. 2. 51-58
Fukunaga, K., Shinoda, Y. Pathophysiological role of sigma-1 receptor in Amyotrophic lateral sclerosis. Seikagaku. 2017. 89. 1. 106-110
Kohji Fukunaga, Yasuharu Shinoda, Hideaki Tagashira. The role of SIGMAR1 gene mutation and mitochondrial dysfunction in amyotrophic lateral sclerosis. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2015. 127. 1. 36-41

Professional career (1)：

博士(薬科学) (東北大学)

Work history (3)：

2022/04 - 現在 Fukuoka University
2017/04 - 2022/03 Tohoku University Graduate School of Pharmaceutical Sciences
2014/04 - 2017/03 Tohoku University Graduate School of Pharmaceutical Sciences

Association Membership(s) (7)：

北米神経科学学会 , Japanese Association of Cardiovascular Pharmacology , JAPANESE SOCIETY FOR CHEMICAL BIOLOGY , THE JAPANESE SOCIETY FOR NEUROCHEMISTRY , THE JAPANESE BIOCHEMICAL SOCIETY , THE JAPANESE PHARMACOLOGICAL SOCIETY , THE PHARMACEUTICAL SOCIETY OF JAPAN

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