Shinoda Yasuharu

シノダヤスハル | Shinoda Yasuharu

Affiliation and department：

Research field (3)： Neuroscience - general , Pharmaceuticals - health and biochemistry , Pharmacology

Research keywords (6)：脂肪酸結合タンパク質 , シグマ1受容体 , プロテインホスファタ-ゼ , 神経変性疾患 , 精神疾患 , 循環器疾患

Research theme for competitive and other funds (3)：

2022 - 2025 遠位尿細管特異的遺伝子改変マウスを駆使した急性腎障害機序の解明
2020 - 2023 シグマ1受容体変異を伴う筋萎縮性側索硬化症の病態解明と創薬
2019 - 2022 Development of Therapeutics for Mitochondrial Impairment in Autism Spectrum Disorders

Papers (32)：

Hideaki Tagashira, Md Shenuarin Bhuiyan, Yasuharu Shinoda, Ichiro Kawahata, Tomohiro Numata, Kohji Fukunaga. Sigma-1 receptor is involved in modification of ER-mitochondria proximity and Ca2+ homeostasis in cardiomyocytes. Journal of pharmacological sciences. 2023. 151. 2. 128-133
Kazuya Matsuo, Yasuharu Shinoda, Nona Abolhassani, Yusaku Nakabeppu, Kohji Fukunaga. Transcriptome Analysis in Hippocampus of Rats Prenatally Exposed to Valproic Acid and Effects of Intranasal Treatment of Oxytocin. Frontiers in psychiatry. 2022. 13. 859198-859198
An Cheng, Yi-Fei Wang, Yasuharu Shinoda, Ichiro Kawahata, Tetsunori Yamamoto, Wen-Bin Jia, Hanae Yamamoto, Tomohiro Mizobata, Yasushi Kawata, Kohji Fukunaga. Fatty acid-binding protein 7 triggers α-synuclein oligomerization in glial cells and oligodendrocytes associated with oxidative stress. Acta pharmacologica Sinica. 2021. 43. 3. 552-562
Yifei Wang, Yasuharu Shinoda, An Cheng, Ichiro Kawahata, Kohji Fukunaga. Epidermal Fatty Acid-Binding Protein 5 (FABP5) Involvement in Alpha-Synuclein-Induced Mitochondrial Injury under Oxidative Stress. Biomedicines. 2021. 9. 2. 110-110
Naoya Fukui, Hanae Yamamoto, Moe Miyabe, Yuki Aoyama, Kunihiro Hongo, Tomohiro Mizobata, Ichiro Kawahata, Yasushi Yabuki, Yasuharu Shinoda, Kohji Fukunaga, et al. An α-synuclein decoy peptide prevents cytotoxic α-synuclein aggregation caused by fatty acid binding protein 3. Journal of Biological Chemistry. 2021. 296. 100663-100663

ｍore...

MISC (3)：

Kohji Fukunaga, Hisanao Izumi, Yasushi Yabuki, Yasuharu Shinoda, Norifumi Shioda, Feng Han. Alzheimer's disease therapeutic candidate SAK3 is an enhancer of T-type calcium channels. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2019. 139. 2. 51-58
Fukunaga, K., Shinoda, Y. Pathophysiological role of sigma-1 receptor in Amyotrophic lateral sclerosis. Seikagaku. 2017. 89. 1. 106-110
Kohji Fukunaga, Yasuharu Shinoda, Hideaki Tagashira. The role of SIGMAR1 gene mutation and mitochondrial dysfunction in amyotrophic lateral sclerosis. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2015. 127. 1. 36-41

Professional career (1)：

博士(薬科学) (東北大学)

Work history (3)：

2022/04 - 現在 Fukuoka University
2017/04 - 2022/03 Tohoku University Graduate School of Pharmaceutical Sciences
2014/04 - 2017/03 Tohoku University Graduate School of Pharmaceutical Sciences

Association Membership(s) (7)：

北米神経科学学会 , Japanese Association of Cardiovascular Pharmacology , JAPANESE SOCIETY FOR CHEMICAL BIOLOGY , THE JAPANESE SOCIETY FOR NEUROCHEMISTRY , THE JAPANESE BIOCHEMICAL SOCIETY , THE JAPANESE PHARMACOLOGICAL SOCIETY , THE PHARMACEUTICAL SOCIETY OF JAPAN

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