Kazuki Mochizuki

モチヅキカズキ | Kazuki Mochizuki

Affiliation and department：
Job title： Professor
Homepage URL (1)： http://www.fp.yamanashi.ac.jp/FDN/index.html

Research field (1)： Food sciences

Research theme for competitive and other funds (27)：

2022 - 2025 妊娠期の葉酸過剰摂取による母の腸内細菌叢攪乱が仔の代謝性疾患を誘発する機序の解明
2021 - 2024 A proposal for "anti-dementia dietary habits" based on healthy longevity epigenomics that links dietary habits and cognitive function
2020 - 2024 エピゲノム・メタゲノム交互作用解析による学童期の健康に与える影響の解明
2020 - 2023 世界に先駆けた代謝異常に起因するサルコペニア動物モデルの樹立とヒトによる検証
2020 - 2023 Encourage children to be wise mothers and fathers in the near future: Challenge for solving child malnutrition

2020 - 2023 発育期・成人期の食習慣によるGene bodyエピゲノムの撹乱と代謝疾患発症

2019 - 2023 胎生期の葉酸過剰による代謝異常誘導機構:腸バリア機能とDOHaDとの関連

2018 - 2022 Development of epigenomic markers that enable to perform early assessment and intervention for neurodevelopmental disorders

2017 - 2021 Dietary spermidine and spermine intake strengthen intestine barrier and prevent hepatocyte lipid droplet deposition in rodent short bowel syndrome model

2017 - 2020 trategy of prevention and amelioration of atherosclerosis caused by repeated postprandial hyperglycemia

2017 - 2020 Study on epigenetic markers for diabetes risk indicating the personal history of postprandial hyperglycemia

2017 - 2020 Epigenetic amelioration of overfeeding-inducible functional declines in various organs by medium-chain fatty acids

2016 - 2019 Research on the inflammatory biomarkers in human after consuming the flavonoid-enriched meals fixed by normal daily food for utilizing food functionality.

2015 - 2018 Enhancement of digestion and absorption function in small intestine by dietary components through transcriptional elongation factor

2015 - 2018 Elucidation of a mehcanism of Diabete mellitus attributed to ectopic fat and its suppressive effect with food ingredients

2014 - 2017 Development of a novel culture method for obtaining human iPS cells with high pluripotency

2014 - 2017 Development of epigenome biomakers reflecting the eating habit

2014 - 2017 Mechanism underlying accumulation of dietary life by the novel epigenetic factor Brd4

2013 - 2016 Analysis of action mechanism of endocrine-disruptors targeting epigenetic memory

2012 - 2015 Molecular mechanisms of astringent reception in gastrointestinal tract by poorly absorbable polyphenols

2012 - 2015 Exploration of key factors for recovering the gastrointestinal tract by the approach of comparative biology and the application to the enteral feeding

2012 - 2015 Development of practical biomarkers for metabolic disease risks

2011 - 2014 Study on risk reduction of lifestyle-related diseases due to modulations of digestion/absorption capability of carbohydrates.

2010 - 2014 Relation between epigenetic regulation by postprandial hyperglycemia and development of metabolic diseases

2008 - 2010 Molecular basis of the rhythmical expression of the genes in the gastrointestinal tract

2006 - 2007 小腸におけるエピジェネティック調節と栄養素・ホルモンの役割

2006 - 2007 Study on the molecular basis of the response of the digestive tract evoked by nutrients/ food factors

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Papers (169)：

Mayu Kimura, Shiori Ishiyama, Takashi Ando, Yuji Tanaka, Keiko Ozato, Kazuki Mochizuki. Dietary medium-chain triglycerides upregulate metabolic gene expression in the gastrocnemius and downregulate expression of muscle-degradation gene in the soleus in aged bromodomain-containing 4 heterozygous mice. PharmaNutrition. 2023. 26. 100361-100361
Aya Harasawa, Shiori Ishiyama, Kazuki Mochizuki. Fructo-oligosaccharide-mediated alteration in claudin expression in small intestinal absorptive Caco-2 cells is positively associated with the induction of inflammatory genes and the glucan receptor gene CLEC7A. Nutrition (Burbank, Los Angeles County, Calif.). 2023. 115. 112140-112140
Kunio Miyake, Kazuki Mochizuki, Megumi Kushima, Ryoji Shinohara, Sayaka Horiuchi, Sanae Otawa, Yuka Akiyama, Tadao Ooka, Reiji Kojima, Hiroshi Yokomichi, et al. Maternal protein intake in early pregnancy and child development at age 3 years. Pediatric research. 2023. 94. 1. 392-399
Haruka Adachi, Shiori Ishiyama, Kazuki Mochizuki. Dietary protein restriction during pregnancy and/or early weaning reduces the number of goblet cells in the small and large intestines of female mice pups. Biochemistry and biophysics reports. 2023. 34. 101475-101475
Kazuki Mochizuki, Shiori Ishiyama, Ryoji Shinohara, Kunio Miyake, Megumi Kushima, Reiji Kojima, Sayaka Horiuchi, Sanae Otawa, Tadao Ooka, Yuka Akiyama, et al. Association of maternal monocyte and neutrophil counts with hypertensive disorders of pregnancy: The Japan Environment and Children’s Study (JECS). 2023

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MISC (37)：

望月和樹, 木村真由, 川村武蔵, 針谷夏代, 合田敏尚. エネルギー産生回路とエピジェネティックスを介した中鎖脂肪の代謝改善作用オレオサイエンス. オレオサイエンス. 2018. 18. 8. 375-382
Mochizuki K, Hariya N, Kubota T. Novel models of epigenetic gene regulation in the nutritional environment. Developmental Origins of Health and Disease (DOHaD):. From Biological Basis to Clinical Significance in Advances in Experimental Medicine and Biology. 2018. 11-18
Saeko Takami, Kineko Matsumoto, Kazue Honma, Kazuki Mochizuki, Toshinao Goda. Effects of medium chain fatty acid on the expression of the genes related with glycolytic and fatty acid synthetic pathways in the mice refed after starvation. FASEB JOURNAL. 2017. 31
Mochizuki K, Hariya N, Honma K, Goda T. Relationship between epigenetic regulation, dietary habits, and the Developmental Origins of Health and Disease theory. CONGENITAL ANOMALIES. 2017
Kazue Honma, Misa Ikeda, Riko Mawatari, Kazuki Mochizuki, Toshinao Goda. FASTING DURING THE SUCKLING-WEANING TRANSIENT PERIOD IN RATS INDUCES METABOLIC ABNORMALITIES IN ADULTHOOD. ANNALS OF NUTRITION AND METABOLISM. 2017. 71. 615-616

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Patents (1)：

糖尿病モデル動物の作出方法及び糖尿病モデル動物

Books (1)：

エネルギー代謝のつながりと制御
2013

Lectures and oral presentations (68)：

胎生期糖質制限が肝臓における代謝・炎症関連遺伝子のmRNA に与える影響
(第10回日本DOHaD学会学術集会 2022)
クメール料理における加熱調理後食品重量からの栄養価の推定
(山梨県栄養士会 2022)
石山詩織、木村真由、中川隆生、藤本由佳、岸上哲士、望月和樹
(糖尿病性腎症研究会 2021)
自然糖尿病モデルNSYマウスにおける中鎖脂肪とキサンチンオキシダーゼ阻害剤の糖尿病性腎症抑制効果の検証
(糖尿病性腎症研究会 2021)
中鎖脂肪とトマトパウダーの共投与はラット肝臓におけるリコペン蓄積を増大させ、糖・脂質代謝関連遺伝子の発現を低下させる
(第11回機能油脂懇話会 2021)

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Professional career (1)：

2002年3月博士(食品栄養科学) 取得

Work history (1)：

2016/12/01 - 山梨大学生命環境科学部地域食物科学科教授

Awards (3)：

2018/05 - 山梨学術アカデミー奨励賞エピジェネティックスを介した代謝疾患発症機構と食品因子の役割
2014/03 - BBB Most-Cited Paper Award(日本農芸化学会)
2009/05 - 2009年5月日本栄養・食糧学会奨励賞受賞

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