Saeki Noritaka

サエキノリタカ | Saeki Noritaka

Affiliation and department：
Job title： Senior Assistant Professor
Other affiliations (1)：

Ehime University Institute for Promotion of Science and Technology, Proteo-Science Center Senior Assistant Professor

Research field (5)： Veterinary medicine , Zoological sciences , Anatomy , Cell biology , Laboratory animal science

Research keywords (11)： Macrophages , Stromal cell , Sexual dimorphism , Estradiol , Estrogen receptor , Autoimmune disease , Chronic inflammation , Epigenetics , 細胞接着 , Cell migration , Cell-cell interactions

Research theme for competitive and other funds (14)：

2024 - 2028 エストロゲンを基軸とした臓器連関による関節リウマチ病態の性差構築機構の解明
2023 - 2028 Macrophage functions in sexual dimorphism of rheumatoid arthritis: Estrogen signaling and cellular metabolism
2022 - 2025 Establishment of cetacean iPS cells and application to neurotoxicity assays of environmental pollutants
2022 - 2024 Development of Novel Therapy for Rheumatoid Arthritis by Regulation of DNA Methylation
2021 - 2024 Investigation of sexual dimorphism of rheumatoid arthritis focusing on synovial macrophages.

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Papers (17)：

Shuhei Yoshida, Aoi Ikedo, Yuta Yanagihara, Tomohisa Sakaue, Noritaka Saeki, Yuuki Imai. Bub1 suppresses inflammatory arthritis-associated bone loss in mice through inhibition of TNFα-mediated osteoclastogenesis. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2024
Noritaka Saeki, Yuuki Imai. Crosstalk between synovial macrophages and fibroblasts in rheumatoid arthritis. Histology and histopathology. 2023. 18628-18628
Hiroaki Kato, Noritaka Saeki, Matome Imai, Hiroshi Onji, Akiko Yano, Shuhei Yoshida, Tomohisa Sakaue, Toru Fujioka, Takashi Sugiyama, Yuuki Imai. LIM1 contributes to the malignant potential of endometrial cancer. Frontiers in Oncology. 2023. 13
Noritaka Saeki, Yuuki Imai. Isolation and Culture of Primary Synovial Macrophages and Fibroblasts from Murine Arthritis Tissue. Journal of Visualized Experiments. 2023. 192
Noritaka Saeki, Kazuki Inoue, Maky Ideta-Otsuka, Kunihiko Watamori, Shinichi Mizuki, Katsuto Takenaka, Katsuhide Igarashi, Hiromasa Miura, Shu Takeda, Yuuki Imai. Epigenetic regulator UHRF1 orchestrates proinflammatory gene expression in rheumatoid arthritis in a suppressive manner. The Journal of clinical investigation. 2022. 132. 11

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MISC (32)：

佐伯法学, 今井祐記. 関節リウマチの病態を網羅的に制御する分子UHRF1. 整形・災害外科. 2023. 66巻. 2号. 199-203
佐伯法学, 井上和樹, 大塚まき, 渡森一光, 水木伸一, 竹中克斗, 五十嵐勝秀, 三浦裕正, 今井祐記. エピジェネティック制御因子UHRF1は関節リウマチの多様な増悪因子を抑制する. 日本骨代謝学会学術集会プログラム抄録集. 2021. 39回. 151-151
沢田雄一郎, 飯尾浩之, 柳原裕太, 池戸葵, 佐伯法学, 榊原伊織, Balazs Gyoerffy, 岸田健, 宮城洋平, 菊川忠彦, et al. GPRC5Aは前立腺癌の細胞増殖および骨転移を促進する. 日本泌尿器科学会総会. 2020. 108回. 1532-1532
佐伯法学, 井上和樹, 大塚まき, 渡森一光, 水木伸一, 竹中克斗, 五十嵐勝秀, 三浦裕正, 今井祐記. DNAメチル化制御分子UHRF1は関節リウマチの病態増悪を抑制する. 日本骨代謝学会学術集会プログラム抄録集. 2020. 38回. 150-150
沢田雄一郎, 菊川忠彦, 飯尾浩之, 榊原伊織, 吉田周平, 池戸葵, 柳原裕太, 佐伯法学, Gyorffy Balazs, 岸田健, et al. GPRC5Aは前立腺癌の細胞増殖および骨転移を促進する. 日本骨代謝学会学術集会プログラム抄録集. 2019. 37回. 156-156

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Books (1)：

Rheumatoid Arthritis: Methods and Protocols (Methods in Molecular Biology, 2766)
Humana 2024 ISBN:1071636812

Lectures and oral presentations (35)：

Epigenetic Regulator UHRF1 Contributes to Synovial Homeostasis in Rheumatoid Arthritis
(The 36rd Annual Meeting of the Japanese Society of Cartilage Metabolism 2024)
ERα signaling in resident synovial macrophages promotes inflammatory arthritis via the activation of cellular metabolism
(The American Society for Bone and Mineral Research 2023 Annual Meeting 2023)
ERα signaling in synovial macrophage promotes inflammatory arthritis via excessive metabolic flux
(PROTEIN ISLAND MATSUYAMA 2023 2023)
DNA methylation regulator UHRF1 suppresses exacerbation of rheumatoid arthritis.
(The 41th Annual Meeting of the Japanese Society for Bone and Mineral Research 2023)
Estrogen receptor-alpha signaling in synovial macrophages promotes inflammatory arthritis through the regulation of cellular metabolism
(The 41th Annual Meeting of the Japanese Society for Bone and Mineral Research 2023)

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Education (2)：

2012 - 2016 Osaka Prefecture University Graduate School of Life and Environmental Sciences Division of Veterinary Sciences
2006 - 2012 Osaka Prefecture University School of Life and Environmental Sciences Department of Veterinary Sciences

Professional career (1)：

Doctor of Veterinary Medicine (Osaka Prefecture University)

Work history (7)：

2022/04 - 現在 Ehime University Division of Medical Research Support, Advanced Research Support Center Senior Assistant Professor
2021/07 - 現在 Ehime University Division of Integrative Pathophysiology, Proteo-Science Center Senior Assistant Professor
2021/07 - 2022/03 Ehime University Division of Laboratory Animal Research, Advanced Research Support Center Senior Assistant Professor
2016/08 - 2021/06 Ehime University Division of Integrative Pathophysiology, Proteo-Science Center Assistant Professor
2016/07 - 2021/06 Ehime University Division of Laboratory Animal Research, Advanced Research Support Center Assistant Professor

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Committee career (3)：

2023/04 - 現在 The Japanese Association for Laboratory Animal Facilities of National University Corporations The committee of medium-size animal
2020/01 - 現在 Kyusyu Experimental Animal Research Association Councilor
2018/04 - 現在 PHC Holdings Corporation Animal Experiment Committee Review Member

Awards (9)：

2023/11 - 愛媛大学生物科学奨励賞
2023/07 - The Japanese Society for Bone and Mineral Reserch Best Presentation Award
2023/06 - The Japanese Society for Bone and Mineral Reserch ASBMR 2023 Travel Award
2023/06 - Ehime University 愛媛大学大学院医学系研究科長優秀論文賞最優秀賞
2022/05 - European Calcified Tissue Society ECTS 2022 East-Meets-West Research Award

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Association Membership(s) (6)：

Japanese Association for Laboratory Animal Medicine , THE JAPANESE ASSOCIATION OF ANATOMISTS , JAPANESE SOCIETY FOR BONE AND MINERAL RESEARCH , THE JAPANESE SOCIETY OF VETERINARY SCIENCE , Japanese Society of Osteoimmunology , Kyusyu Experimental Animal Research Association

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