Rchr
J-GLOBAL ID:201701007557959543
Update date: Feb. 12, 2024
Nishiguchi Koji
ニシグチ コウジ | Nishiguchi Koji
Affiliation and department:
Job title:
Professor
Research field (1):
Neuroscience - general
Research keywords (4):
視覚再建・弱視
, genetic diagnosis
, retinal degeneration
, gene therapy
Research theme for competitive and other funds (15):
- 2023 - 2026 Early diagnosis before onset of disease pioneered by the evaluation of vascular permeability and waste excretion function for the brain and sensory organs
- 2022 - 2025 網膜色素変性を自然発症するカニクイザルの繁殖と治療法開発への応用
- 2021 - 2024 網膜色素変性症治療のための高効率なゲノム編集遺伝子治療の開発
- 2020 - 2023 エピゲノム編集による抹消血を用いた網膜色素変性病因遺伝子の発現解析法の開発
- 2019 - 2022 The study of determining the disease pathogenesis and developing the attractive animal disease model using cynomolgus monkeys with retinitis pigmentosa
- 2018 - 2021 Development of a novel CRISPR-Cas9 vector for functional analysis of retinal disease-related genes
- 2016 - 2019 Comparison of plasticity between rod and cone visual pathways
- 2016 - 2018 In vivo imaging of retinal ganglion cell function using adeno-associated virus
- 2014 - 2017 Research for blood RNA marker predicting prognosis of glaucoma focusing on the early and individualized medicine.
- 2014 - 2016 Search for genetic causes and autoantibodies of retinitis pigmentosa sine pigmento
- 2011 - 2012 眼内炎症における補体系と眼内液中硫酸化グリコサミノグリカンの役割の検討
- 2009 - 2010 Regulatory mechanisms of neuronal regeneration in the retina and role of the pars plana.
- 2008 - 2010 Elucidating the molecular pathology and development of treatment modalities for ischemic retinopathies
- 2007 - 2008 The analyses of photoreceptor regeneration from cilio-retinal stem cells using flatmount technique
- 2007 - 2008 Intraocular implantation of encapsulated neurotrophic factor-secreting cell
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Papers (122):
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Yukihiro Shiga, Kazuki Hashimoto, Kosuke Fujita, Shigeto Maekawa, Kota Sato, Shintaroh Kubo, Kazuhide Kawase, Kana Tokumo, Yoshiaki Kiuchi, Sotaro Mori, et al. Identification of OPTN p.(Asn51Thr): A novel pathogenic variant in primary open-angle glaucoma. Genetics in Medicine Open. 2024. 2. 100839-100839
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Kensuke Goto, Yoshito Koyanagi, Masato Akiyama, Yusuke Murakami, Masatoshi Fukushima, Kohta Fujiwara, Hanae Iijima, Mitsuyo Yamaguchi, Mikiko Endo, Kazuki Hashimoto, et al. Disease-specific variant interpretation highlighted the genetic findings in 2325 Japanese patients with retinitis pigmentosa and allied diseases. 2023
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Katsuya Yamaguchi, Ryo Tomita, Yoshito Koyanagi, Kazuhide Kawase, Ryo Asaoka, Hiroko Terasaki, Takeshi Iwase, Koji M Nishiguchi. Abilities of circumpapillary retinal nerve fiber layer thickness and vascular density to discriminate stages in primary open-angle glaucoma. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. 2023
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中野 裕太, 安田 小百合, 溝渕 圭, 池田 麻衣子, 濱島 崇, 上野 真治, 西口 康二, 林 孝彰. Ornithine aminotransferase(OAT)遺伝子の複合ヘテロ接合性変異による脳回状脈絡網膜萎縮症の男児例. 日本眼科学会雑誌. 2023. 127. 11. 1069-1080
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Ai Fujita Sajiki, Yoshito Koyanagi, Hiroaki Ushida, Kenichi Kawano, Kosuke Fujita, Daishi Okuda, Mitsuki Kawabe, Kazuhisa Yamada, Ayana Suzumura, Shu Kachi, et al. Association Between Torque Teno Virus and Systemic Immunodeficiency in Patients With Uveitis With a Suspected Infectious Etiology. American journal of ophthalmology. 2023. 254. 80-86
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MISC (41):
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小柳 俊人, 佐治木 愛, 牛田 宏昭, 小松 紘之, 鈴村 文那, 山田 和久, 川部 満希, 川野 健一, 兼子 裕規, 臼井 嘉彦, et al. 眼炎症性疾患のロングリードシーケンスによる迅速なメタゲノム解析. 日本眼科学会雑誌. 2023. 127. 臨増. 228-228
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村上晶, 高丹, 藤巻拓郎, 舟木俊成, 山口昌大, 川村雄一, 藤木慶子, 岩田文乃, 平形寿彬, 平塚義宗, et al. Ophthalmologic Genetics-Molecular Genetics and Developments in Therapeutic Strategies for Intractable Eye Diseases-. 日本眼科学会雑誌. 2021. 125. 3
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西口康二, 国松志保, 國方彦志, 中澤徹, 中澤徹. Autosomal Recessive Bestrophinopathy Complicated by Angle Closure: a Case Report. 日本眼科学会雑誌. 2020. 124. 9
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Fumihiko Mabuchi, Yoichi Sakurada, Kenji Kashiwagi, Mitsuko Takamoto, Makoto Aihara, Takeshi Iwata, Kazuki Hashimoto, Kota Sato, Yukihiro Shiga, Koji Nishiguchi, et al. Prediction of glaucomatous visual field progression by genetic variants associated with primary open-angle glaucoma. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2019. 60. 9
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長田麗, 國方彦志, 安田正幸, 橋本和軌, 相澤奈帆子, 西口康二, 阿部俊明, 中澤徹. 特発性黄斑前膜術後の網膜感度と術前の黄斑血管密度との関係. 日本眼科学会雑誌. 2019. 123. 臨増. 173-173
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Professional career (1):
Work history (7):
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