MARIKO MORII

Affiliation and department：

Research field (2)： Molecular biology , Hematology and oncology

Research theme for competitive and other funds (6)：

2023 - 2026 ダウン症造血幹細胞の機能障害とクローン性造血機序の解析
2022 - 2025 ストレス造血におけるエピゲノム制御を介した幹細胞運命決定と造血再生機序の解析
2020 - 2023 Understanding the role of TIF1 in BCR-ABL-expressing leukemic stem cells
2019 - 2022 年齢依存的造血幹細胞特性の変化と白血病発症機構の解明
2018 - 2020 The age dependent leukemogenesis induced by RUNX1 mutatnt and BCR-ABL

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Papers (25)：

Mariko Morii, Sho Kubota, Mihoko Iimori, Takako Yokomizo-Nakano, Ai Hamashima, Jie Bai, Akiho Nishimura, Masayoshi Tasaki, Yukio Ando, Kimi Araki, et al. TIF1β activates leukemic transcriptional program in HSCs and promotes BCR::ABL1-induced myeloid leukemia. Leukemia. 2024. 38. 6. 1275-1286
Sho Kubota, Yuqi Sun, Mariko Morii, Jie Bai, Takako Ideue, Mayumi Hirayama, Supannika Sorin, Eerdunduleng, Takako Yokomizo-Nakano, Motomi Osato, et al. Chromatin modifier Hmga2 promotes adult hematopoietic stem cell function and blood regeneration in stress conditions. The EMBO Journal. 2024
Takako Yokomizo-Nakano, Ai Hamashima, Sho Kubota, Jie Bai, Supannika Sorin, Yuqi Sun, Kenta Kikuchi, Mihoko Iimori, Mariko Morii, Akinori Kanai, et al. Exposure to microbial products followed by loss of Tet2 promotes myelodysplastic syndrome via remodeling HSCs. Journal of Experimental Medicine. 2023
Yo Hamaguchi, Tatsuro Kondoh, Masafumi Fukuda, Kazumi Yamasaki, Koh-Ichiro Yoshiura, Hiroyuki Moriuchi, Mariko Morii, Masashi Muramatsu, Takashi Minami, Motomi Osato. Leukopenia, macrocytosis, and thrombocytopenia occur in young adults with Down syndrome. Gene. 2022. 835. 146663-146663
Supannika Sorin, Sho Kubota, Sofiane Hamidi, Takako Yokomizo-Nakano, Kulthida Vaeteewoottacharn, Sopit Wongkham, Sakda Waraasawapati, Chawalit Pairojkul, Jie Bai, Mariko Morii, et al. HMGN3 represses transcription of epithelial regulators to promote migration of cholangiocarcinoma in a SNAI2-dependent manner. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2022. 36. 7. e22345

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Lectures and oral presentations (1)：

UV 照射によるアポトーシス誘導における Src シグナリングの役割
(BMB2015 (第 38 回日本分子生物学会年会, 第 88 回日本生化学会大会合同大会) 2015)

Education (2)：

2013 - 2017 Chiba University Graduate School of Medical and Pharmaceutical Sciences
2007 - 2013 Chiba University Faculty of Pharmaceutical Sciences

Work history (5)：

2022/07 - 現在 Japan Society for the Promotion of Science
2019/04 - 2022/06 Japan Society for the Promotion of Science
2018/09 - 2019/03 Kumamoto University International Research Center for Medical Sciences
2017/04 - 2018/08 Japan Society for the Promotion of Science
2016/04 - 2017/03 Japan Society for the Promotion of Science

Awards (5)：

2024/10 - JSH Young Investigator’s Award Premature aging and HSC defects in Down syndrome
2018/11 - 白血病研究基金若手奨励研究賞一般研究賞
2017/03 - 千葉大学学長表彰
2017/03 - 千葉大学医学薬学府長表彰
2015/03 - 日本薬学会第135年会優秀発表賞

Association Membership(s) (1)：

日本血液学会

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