Takahiro Nakayama

ナカヤマタカヒロ | Takahiro Nakayama

Affiliation and department：
Job title： Associate Professor
Homepage URL (2)： https://ridb.kanazawa-u.ac.jp/public/detail.php?id=4087 , https://ridb.kanazawa-u.ac.jp/public/detail_en.php?id=4087

Research field (2)： Molecular biology , Biophysics

Research keywords (1)： Single molecule observation, Cell biophysics, Atomic force microscopy

Research theme for competitive and other funds (13)：

2023 - 2026 Supramolecular behavior and dynamic capture of meta-aggregates
2023 - 2026 Universalization of high-speed atomic force microscopy targets
2023 - 2026 Investigation of relationship between structural variety and function of tumor suppressor protein, p53
2020 - 2021 がん抑制因子p53の凝集の立体構造動態と機能の解明
2017 - 2021 Study on transmission of Abeta aggregates and its prevention

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Papers (60)：

Nao Takahashi, Tatsuya Kimura, Yuki Terauchi, Takumi Tanaka, Akira Yoshimi, Takahiro Watanabe-Nakayama, Keietsu Abe. High-speed atomic force microscopy reveals surface-catalyzed elongation mechanism of fungal functional amyloid, hydrophobin RolA. 2025
Yanliang Liu, Saisai Liu, Yasuhisa Sakamoto, Paweenapon Chunthaboon, Chanida Thinyakul, Ryunosuke Mori, Shuran Li, Takahiro Watanabe-Nakayama, Seiji Omata, Yasuyuki Morita, et al. LATS1/2-Integrin Axis Confers Tumor-Generated Forces That Activate Neighboring Fibroblasts. Cancer Science. 2025
Daiki Muramatsu, Takahiro Watanabe-Nakayama, Mayumi Tsuji, Kenichi Umeda, Sadao Hikishima, Hiroto Nakano, Yasuhiro Sakashita, Tokuhei Ikeda, Hiroki Konno, Noriyuki Kodera, et al. ALZ-801 prevents amyloid β-protein assembly and reduces cytotoxicity: A preclinical experimental study. The FASEB Journal. 2025. 39. 3
Bikash R. Sahoo, Takahiro Watanabe-Nakayama, Saba Suladze, G. M. Anantharamaiah, Bernd Reif, Ayyalusamy Ramamoorthy. Bifunctional nanodisc platforms for studies on self-assembly and amyloid fibrillation. Chemical Communications. 2025. 61. 66. 12349-12352
Kenjiro Ono, Moeko Noguchi-Shinohara, Takahiro Watanabe-Nakayama. The basis of anti-Aβ antibody therapy: The toxicity of Aβ aggregates and the mechanism of action of anti-Aβ antibodies. Internal medicine (Tokyo, Japan). 2024

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MISC (49)：

中山隆宏, 小野賢二郎. Structural dynamics of pathogenic protein aggregates revealed by high-speed atomic force microscopy. Dementia Japan. 2026. 40. 1
平岡真宙, 松原琴音, 中山瑞穂, 中山瑞穂, 高橋亮, 志波公平, 梅田健一, 紺野宏記, 古寺哲幸, 安藤敏夫, et al. がん抑制因子p53四量体の構造動態の観察. 日本分子生物学会年会プログラム・要旨集(Web). 2025. 48th
中山隆宏. メタアグリゲート形成過程の構造動態可視化に向けた高速AFM技術の応用と展望. Dementia Japan. 2025. 39. 4
村松大輝, 中山隆宏, 辻まゆみ, 梅田健一, 疋島貞雄, 中野博人, 坂下泰浩, 池田篤平, 紺野宏記, 古寺哲幸, et al. 高速原子間力顕微鏡を用いたALZ-801によるアミロイドβ蛋白凝集抑制効果の解析. Dementia Japan. 2025. 39. 4
中山隆宏. 高速原子間力顕微鏡によるアミロイド凝集構造動態の1分子可視化. 日本アミロイドーシス学会学術集会プログラム・抄録集. 2025. 12th

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Books (3)：

いま新薬で加速する神経変性疾患研究 : 異常タンパク質の構造、凝集のしくみから根本治療の真の標的に迫る
羊土社 2023 ISBN:9784758104128
Cells, Forces, and the Microenvironment
CRC Press 2015 ISBN:9789814613361
Atomic force microscopy in liquid : biological applications
Wiley-VCH 2012 ISBN:9783527327584

Lectures and oral presentations (18)：

高速AFMで迫るアミロイド凝集のリアルタイム構造動態と阻害剤の作用
(大阪大学蛋白質研究所セミナー(アミロイド疾患病態メカニズム研究会) 2025)
メタアグリゲート形成過程の構造動態可視化に向けた高速 AFM 技術の応用と展望
(日本認知症学会 2025)
高速原子間力顕微鏡によるアミロイド凝集構造動態の1分子可視化
(日本アミロイドーシス学会 2025)
High-speed AFM visualization of structural dynamics and aggregation mechanisms in amyloidogenic proteins
(Biophysical Society of Japan 2025)
アミロイド凝集構造動態の単分子ビデオイメージング
(第64回日本神経病理学会総会学術研究会・第66回日本神経化学会大会合同大会 2023)

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Education (3)：

2005 - 2008 Tokyo Institute of Technology Interdisciplinary Graduate School of Science and Engineering Department of Electronic Chemistry
2001 - 2003 Hiroshima University Graduate School of Science Department of Biological Science
1997 - 2001 Hiroshima University Faculty of Education

Professional career (1)：

Work history (6)：

2017/10 - 現在 Nano Life Science Institute, Kanazawa University Associate Professor
2017/04 - 2017/09 Bio-AFM Frontier Research Center, Kanazawa University Associate Professor
2012/04 - 2017/03 Bio-AFM Frontier Research Center, Kanazawa University Assistant Professor
2008/04/01 - 2012/03/31 Tokyo Institute of Technology Postdoctoral Researcher
2004/04/01 - 2005/03/01 Japan Science and Technology Agency

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Association Membership(s) (3)：

Biophysical Society , 日本生物物理学会 , 日本分子生物学会

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