Rchr
J-GLOBAL ID:201701009420122983   Update date: Apr. 07, 2026

Higuchi Takuma

ヒグチ タクマ | Higuchi Takuma
Affiliation and department:
Homepage URL  (1): http://www.kochi-u.ac.jp/kms/ct_mrc/academic/
Research field  (2): Molecular biology ,  Medical biochemistry
Research keywords  (6): microRNA ,  RNA結合タンパク質 ,  RNA modification ,  hepatocellular carcinoma ,  代謝機能障害関連脂肪肝炎 ,  非アルコール性脂肪肝炎
Research theme for competitive and other funds  (8):
  • 2023 - 2026 miRNA生合成阻害因子によるNASH発症・増悪化の新たな調節機構の解明
  • 2018 - 2023 Preservation of mammalian genetic resources and study for the developmental mechanism using freeze-dried cells
  • 2019 - 2022 The effect of RNA binding proteins on regulatory mechanisms of anti-fibrotic and anti-inflammatory miRNA biogenesis
  • 2020 - 2021 RNA修飾によるがん抑制miRNA産生性制御機構の解明
  • 2016 - 2019 Elucidation of molecular mechanisms through RNA-RNA binding protein network in physiological regulation and disease onset
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Papers (24):
  • Susumu Muroya, Koichi Ojima, Arata Banno, Hirotaka Nagai, Kazumasa Kakibuchi, Takuma Higuchi, Shuji Sakamoto, Kazutsugu Matsukawa. Dietary Citrus Peel Supplementation Enhances Hepatic Energy Metabolism, Muscle 9-HODE Generation and Isoleucine Catabolism in Beef Cattle. Metabolites. 2026. 16. 3. 201-201
  • Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto. Domain associated with zinc fingers-containing NF90-NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity. FEBS Open Bio. 2025
  • Misaki Yoshikuni, Kazuki Iguchi, Yasuhiro Otoguro, Shun Sato, Hirotaka Nagai, Yasuo Takemura, Arata Banno, Takuma Higuchi, Shuji Sakamoto, Susumu Muroya, et al. Chiral derivatization LC-TOF/MS analysis reveals presence of D-amino acids in bovine skeletal muscle tissue and the cultured cells. Journal of Food Composition and Analysis. 2025. 144. 107722-107722
  • Senthilkumar Preethy, Shuji Sakamoto, Takuma Higuchi, Koji Ichiyama, Naoki Yamamoto, Nobunao Ikewaki, Masaru Iwasaki, Vidyasagar Devaprasad Dedeepiya, Subramaniam Srinivasan, Kadalraja Raghavan, et al. Enhanced expression of dystrophin, IGF-1, CD44 and MYH3 in plasma and skeletal muscles including diaphragm of mdx mice after oral administration of Neu REFIX beta 1,3-1,6 glucan. Scientific reports. 2025. 15. 1. 7232-7232
  • Todaka Hiroshi, Arikawa Mikihiko, Noguchi Tatsuya, Ichikawa Atsushi, Higuchi Takuma, Sakamoto Shuji, Sato Takayuki. Promoting effect of sigma-1 receptor on the skeletal muscle differentiation and regeneration(タイトル和訳中). The Journal of Physiological Sciences. 2024. 74. Suppl.2. 223-223
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MISC (45):
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Lectures and oral presentations  (2):
  • 褐毛和種高地形に対する柚子可否配合飼料の効果〜骨格筋、肝臓における網羅的遺伝子発現解析〜
    (第3回「土佐あかうしの肉質・ブランド力強化」事業シンポジウム DXが拓く土佐あかうしの未来 2024)
  • 二本鎖RNA結合タンパク質複合体NF90-NF45によるm6A修飾制御を介したがん抑制miRNA生合成調節
    (第46回 日本分子生物学会年会 2023)
Professional career (1):
  • 博士(医学) (高知大学)
Work history (2):
  • 2026/04 - 現在 Kochi University Lecturer
  • 2015/01 - 2026/03 Kochi University Research and Education Faculty Medical Sciences Cluster Basic Medicine Unit Assistant professor
Committee career (1):
  • 2024/06 - 2025/06 日本生化学会 中国四国支部 第66回 日本生化学会 中国四国支部例会 実行委員
Awards (4):
  • 2025/04 - 令和7年度 高知信用金庫医学研究賞 マイクロRNA産生制御因子が引き起こす代謝機能障害関連脂肪肝炎-肝細胞がんの発症・増悪化の機序解明
  • 2024/06 - 第65回 日本生化学会 中国・四国支部例会 優秀発表賞(若手)
  • 2023/03 - 高知大学 若手教員研究優秀賞 (令和4年度高知大学研究顕彰制度 ) RNA結合タンパク質が引き起こす疾患病態の機序解明
  • 2017/05 - 第58回 日本生化学会中国・四国支部例会 優秀研究賞
Association Membership(s) (3):
THE RNA SOCIETY OF JAPAN ,  THE MOLECULAR BIOLOGY SOCIETY OF JAPAN ,  THE JAPANESE BIOCHEMICAL SOCIETY
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