Research theme for competitive and other funds (12):
2021 - 2026 細胞間接着を起点とした細胞競合の分子機構とその生理的制御機構の解明
2024 - 2026 細胞間接着装置による創傷治癒応答の空間スケールの制御機構の解明
2020 - 2023 接着と張力の操作で明らかにする上皮ダイナミクス
2018 - 2021 Modular organization of tight junctions and its roles in epithelial plasticity
2019 - 2021 上衣細胞間接着の異常を起点とした水頭症発症機構の解明
2017 - 2019 Role of cell competition in epithelial barrier homeostasis
2016 - 2019 Reconstitution of paracellular transport by establishment of a claudin-deficient epithelial cell line.
2017 - 2019 上皮極性における密着結合の役割の解明
2017 - 2019 密着結合のフェンス機能の分子的基盤の解明
2016 - 2018 Mechanisms of tension homeostasis and its role in epithelial morphogenesis
2015 - 2017 細胞内物流の中継基地の機能とその成立機構の解明
2012 - 2015 Regulation of motor-cargo interaction in cytoplasmic dynein-dependent intracellular transport
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Papers (26):
Thanh Phuong Nguyen, Tetsuhisa Otani, Motosuke Tsutsumi, Noriyuki Kinoshita, Sachiko Fujiwara, Tomomi Nemoto, Toshihiko Fujimori, Mikio Furuse. Tight junction membrane proteins regulate the mechanical resistance of the apical junctional complex. Journal of Cell Biology. 2024
Hiroshi Koyama, Hisashi Okumura, Tetsuhisa Otani, Atsushi M. Ito, Kazuyuki Nakamura, Kagayaki Kato, Toshihiko Fujimori. Effective mechanical potential of cell-cell interaction in tissues harboring cavity and in cell sheet toward morphogenesis. 2023
Hiroshi Koyama, Hisashi Okumura, Atsushi M Ito, Kazuyuki Nakamura, Tetsuhisa Otani, Kagayaki Kato, Toshihiko Fujimori. Effective mechanical potential of cell-cell interaction explains three-dimensional morphologies during early embryogenesis. PLoS computational biology. 2023. 19. 8. e1011306
Shintaro Miyazaki, Tetsuhisa Otani, Kei Sugihara, Toshihiko Fujimori, Mikio Furuse, Takashi Miura. Mechanism of interdigitation formation at apical boundary of MDCK cell. iScience. 2023. 106594-106594
Alexis J. Haas, Ceniz Zihni, Susanne M. Krug, Riccardo Maraspini, Tetsuhisa Otani, Mikio Furuse, Alf Honigmann, Maria S. Balda, Karl Matter. ZO-1 Guides Tight Junction Assembly and Epithelial Morphogenesis via Cytoskeletal Tension-Dependent and -Independent Functions. Cells. 2022
1996 - 2000 Kyoto University Faculty of Science Faculty of Science
Professional career (1):
博士(生命科学) (京都大学)
Work history (5):
2023/10 - 現在 Tokyo Metropolitan University
2020/11 - 現在 Japan Science and Technology Agency
2015/10 - 2023/09 National Institute for Physiological Sciences Division of Cell Structure Assistant Professor
2007/04 - 2015/09 RIKEN CDB Laboratory for Morphogenetic Signaling
2005/04 - 2007/03 RIKEN CDB Laboratory for Cell Adhesion and Tissue Patterning
Awards (4):
2021/09 - 4th International Tight Junction Conference Poster award
2012/05 - 第45回日本発生生物学会・第64回日本細胞生物学会合同年会 優秀ポスター賞
2010/05 - 第62回日本細胞生物学会大会 若手優秀発表賞
2007/03 - 第5回国際学生セミナー 最優秀発表賞
Association Membership(s) (4):
THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
, JAPANESE SOCIETY OF DEVELOPMENTAL BIOLOGISTS
, JAPAN SOCIETY FOR CELL BIOLOGY
, The American Society for Cell Biology