Kashio Makiko

カシオマキコ | Kashio Makiko

Affiliation and department：
Job title： Associate professor

Research field (2)： Clinical pharmacy , Physiology

Research keywords (3)： Physiology , Temperature , TRP channel

Research theme for competitive and other funds (4)：

2020 - 2023 体温と代謝をつなぐ体温センサーTRPM2機能制御機構の解明
2017 - 2020 Molecular basis of basolateral CALHM channel sorting in epithelial cells
2015 - 2017 Heteromeric CALHM1/3 in neurotransmission of taste cells
2013 - 2015 Physiological roles of TRPM2 in microglial functions

Papers (32)：

Makiko Kashio. Thermosensitive TRPM2: The regulatory mechanisms of its temperature sensitivity and physiological functions. The Journal of Physiological Sciences. 2025
Kotoha Inoue, Shinya Takenouchi, Misato Kida, Makiko Kashio, Makoto Tominaga, Takahisa Murata. Transient receptor potential vanilloid 4 gene-deficiency attenuates the inhibitory effect of 5,6-dihydroxy-8Z,11Z,14Z,17Z-eicosatetraenoic acid on vascular permeability in mice. Journal of pharmacological sciences. 2025. 157. 1. 35-38
Makiko Kashio. Thermo-TRP regulation by endogenous factors and its physiological function at core body temperature. Physiological Reports. 2025
Makiko Kashio, Sandra Derouiche, Reiko U Yoshimoto, Kenji Sano, Jing Lei, Mizuho A Kido, Makoto Tominaga. Involvement of TRPV4 in temperature-dependent perspiration in mice. eLife. 2024
Tomoyo Ujisawa, Jing Lei, Makiko Kashio, Makoto Tominaga. Thermal gradient ring for analysis of temperature-dependent behaviors involving TRP channels in mice. The journal of physiological sciences : JPS. 2024. 74. 1. 9-9

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MISC (13)：

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Books (1)：

Chapter 31 - TRP channels and thermoregulation; therapeutic opportunities
2024 ISBN:9780443186530

Lectures and oral presentations (33)：

TRPM2チャネル温度感受性調節機構の解明
(日本薬学会第145年会 2025)
Exploring the molecular mechanisms to modulate temperature sensitivity of TRPM2
(APPW2025 2025)
Molecular and neural mechanisms to detect and transmit somatosensation
(APPW2025 2025)
体温センサーTRPM2活性の多因子による調節機構
(令和6年度日本生化学会九州支部例会 2024)
Multiple pathways regulating TRPM2 activity at body temperature
(2024)

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Education (3)：

2008 - 2011 SOKENDAI (The Graduate University for Advanced Studies) School of Life Science Department of Physiological Science
2000 - 2002 Hiroshima University
1996 - 2000 Hiroshima University Faculty of Medicine Institute of Pharmaceutical Sciences

Professional career (1)：

Work history (7)：

2024/04 - 現在 Kumamoto University Department of Cell Physiology, Faculty of Life Sciences Associate Professor
2021/04 - 2024/03 National Institute for Physiological Sciences
2017/04 - 2021/03 Aichi Medical University Department of Physiology Assistant Professor
2014/09 - 2017/03 Kyoto Prefectural University of Medicine Department of Molecular Cell Physiology Assistant Professor
2013/08 - 2014/08 Okazaki Institute for Integrative Bioscience Division of Cell Signaling Postdoctoral fellow

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Awards (3)：

2016/03 - Physiological Society of Japan Irisawa Memorial Promotion Award for Young Physiologists
2012/06 - 4th International Congress on Cell Membranes and Oxidative Stress: Focus on Calcium Signaling and TRP Channels Poster award
2012/05 - 日本生化学会中部支部奨励賞

Association Membership(s) (3)：

日本薬学会 , 日本生化学会 , THE PHYSIOLOGICAL SOCIETY OF JAPAN

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