Research field (2)：
Clinical pharmacy
, Physiology
Research keywords (3)：
Physiology
, Temperature
, TRP channel
Research theme for competitive and other funds (5)：
2020 - 2023 体温と代謝をつなぐ体温センサーTRPM2機能制御機構の解明
2017 - 2020 Molecular basis of basolateral CALHM channel sorting in epithelial cells
2016 - 2019 Neurotransmission of sensory information through CALHM ion channels
2015 - 2017 Heteromeric CALHM1/3 in neurotransmission of taste cells
2013 - 2015 Physiological roles of TRPM2 in microglial functions
Papers (28)：
Makiko Kashio, Makoto Tominaga. Role of novel de novo gain-of-function TRPM3 mutations in a spectrum of neurodevelopmental disorders. Cell calcium. 2023. 110. 102704-102704
Makiko Kashio, Satoru Masubuchi, Makoto Tominaga. Protein kinase C-mediated phosphorylation of transient receptor potential melastatin type 2 Thr738 counteracts the effect of cytosolic Ca2+ and elevates the temperature threshold. The Journal of physiology. 2022. 600. 19. 4287-4302
Thi Hong Dung Nguyen, Stella Chapman, Makiko Kashio, Claire Saito, Tatjana Strom, Mio Yasui, Makoto Tominaga. Single amino acids set apparent temperature thresholds for heat-evoked activation of mosquito transient receptor potential channel TRPA1. The Journal of biological chemistry. 2022. 298. 9. 102271-102271
Makiko Kashio, Makoto Tominaga. TRP channels in thermosensation. Current opinion in neurobiology. 2022. 75. 102591-102591
Tomoyo Ujisawa, Sachiko Sasajima, Makiko Kashio, Makoto Tominaga. Thermal gradient ring reveals different temperature-dependent behaviors in mice lacking thermosensitive TRP channels. The journal of physiological sciences : JPS. 2022. 72. 1. 11-11
Makiko Kashio, Makoto Tominaga. Redox-Sensitive TRP Channels: TRPA1 and TRPM2. Redox - Principles and Advanced Applications. 2017. 203-223
Makiko Kashio, Makoto Tominaga. Subcellular localization of TRPM2 determines the fate of cancer cells, apoptosis or survival. TRANSLATIONAL CANCER RESEARCH. 2017. 6. S409-S411
Akiyuki Taruno, Hongxin Sun, Makiko Kashio, Yoshinori Marunaka. Regulation of CALHM1 channel by protein S-palmitoylation. CHEMICAL SENSES. 2016. 41. 9. E275-E276
Kashio Makiko, Taruno Akiyuki, Sun Hongxin, Kobayashi Kenta, Sano Hiromi, Nambu Atsushi, Marunaka Yoshinori. Adeno-associated virus-mediated gene transduction of taste cells in vivo. CHEMICAL SENSES. 2016. 41. 9. E276-E277
