SAKUMA TETSUSHI

サクマテツシ | SAKUMA TETSUSHI

Affiliation and department：
Job title： CSO
Other affiliations (1)：

Kyoto University Graduate School of Agriculture Program-Specific Professor

Research field (1)： Systems genomics

Research keywords (6)： Gene knockin , Gene knockout , CRISPR-Cas9 , TALEN , Epigenome editing , Genome editing

Research theme for competitive and other funds (19)：

2022 - 2025 オルガノイドを用いた肺大細胞神経内分泌癌の分子病態および発癌メカニズムの解明
2021 - 2024 Development of muliplex, large-scale, and high-resolution genome editing technology using multi-class CRISPR system
2021 - 2024 マウスin vivo エピゲノム編集による焦点性てんかん発症機序の解明
2017 - 2021 Development of genome editing platform technology for various disease models
2019 - 2020 拡張型TREEシステムを用いた新規エピゲノム編集技術の開発とがん研究への応用

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Papers (157)：

Kazuma Nakatani, Hiroyuki Kogashi, Takanori Miyamoto, Taiki Setoguchi, Tetsushi Sakuma, Kazuto Kugou, Yoshinori Hasegawa, Takashi Yamamoto, Yoshitaka Hippo, Yusuke Suenaga. Inhibition of OCT4 binding at the MYCN locus induces neuroblastoma cell death accompanied by downregulation of transcripts with high-open reading frame dominance. Frontiers in oncology. 2024. 14. 1237378-1237378
Shinsei Yambe, Yuki Yoshimoto, Kazutaka Ikeda, Koichiro Maki, Aki Takimoto, Shinnosuke Higuchi, Xinyi Yu, Kenta Uchibe, Shigenori Miura, Hitomi Watanabe, et al. Sclerostin modulates the degree of mineralization and the stiffness profile of the fibrocartilaginous enthesis for mechanical tissue integrity. 2023
Satoshi Ninagawa, Masaki Matsuo, Deng Ying, Shinya Aso, Kazutoshi Matsushita, Akane Fueki, Shunsuke Saito, Koshi Imami, Yasuhiko Kizuka, Tetsushi Sakuma, et al. UGGT1/2-mediated reglucosylation ofN-glycan competes with ER-associated degradation of unstable and misfolded glycoproteins. 2023
Ryo Ezaki, Tetsushi Sakuma, Daisuke Kodama, Ryou Sasahara, Taichi Shiraogawa, Kennosuke Ichikawa, Mei Matsuzaki, Akihiro Handa, Takashi Yamamoto, Hiroyuki Horiuchi. Transcription activator-like effector nuclease-mediated deletion safely eliminates the major egg allergen ovomucoid in chickens. Food and Chemical Toxicology. 2023. 175. 113703-113703
Tahara, Mayu, Higurashi, Norimichi, Hata, Junichi, Nishikawa, Masako, Ito, Ken, Hirose, Shinichi, Kaneko, Takehito, Mashimo, Tomoji, Sakuma, Tetsushi, Yamamoto, Takashi, et al. Developmental changes in brain activity of heterozygous Scn1a knockout rats. FRONTIERS IN NEUROLOGY. 2023. 14

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MISC (80)：

土石川佳世, 馬郡健太, 馬郡健太, 枝廣太郎, 佐藤寛之, 佐藤寛之, 福永早央里, 本庶仁子, 嬉野博志, 嬉野博志, et al. Targeted TCR gene editing using Platinum TALEN and long single-stranded DNA donor template. 日本造血・免疫細胞療法学会総会プログラム・抄録集. 2022. 45th
松下和智, 蜷川暁, 杉本岳大, 岡田徹也, 石川時郎, 佐久間哲史, 山本卓, 森和俊. The regulation by OS9 and XTP3B in ER-associated degradation depends on the degree of structural abnormality of degradation substrates. 日本糖質学会年会要旨集. 2021. 40th
蜷川暁, GEORGE Ginto, 矢木宏和, 住友嘉樹, 真木勇太, 石川時郎, 佐久間哲史, 山本卓, 今見考志, 石濱泰, et al. Elucidation of molecular mechanisms and functions of N-glycan mannose trimming required for glycoprotein ER-associated degradation pathway. 日本糖質学会年会要旨集. 2021. 40th
Nucleic acid and gene delivery system and potential application to genome editing using ultrasound-responsive nanobubbles. 2020. 3. 6. 576-580
中川佳子, 佐久間哲史, 若松和子, 坂本亘, 近藤朋子, 近藤朋子, 石田恵理, 石田恵理, 坂口摩姫, 坂口摩姫, et al. マウス受精卵への簡便なゲノム編集導入法開発の試み. 日本実験動物学会総会講演要旨集(Web). 2020. 67th

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Patents (8)：

PPRモチーフを利用したDNA結合性タンパク質およびその利用
核酸挿入用ベクター
PPRモチーフを利用したDNA結合性タンパク質およびその利
PPRモチーフを利用したDNA結合性タンパク質およびその利用
PPRモチーフを利用したDNA結合性タンパク質およびその利用

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Books (57)：

腎と透析
東京医学社 2023
Epigenomics, Methods in Molecular Biology
Springer Nature 2023
Genome Editing in Animals, Methods in Molecular Biololgy
Springer Nature 2023
Gene and Genome Editing
Elsevier 2022
Scientific Reports
Springer Nature 2022

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Lectures and oral presentations (111)：

微細藻類ナンノクロロプシスにおけるNICSシステムを用いた外来遺伝子フリーノックインの開発
(日本ゲノム編集学会第8回大会 2023)
凍結受精卵を用いたゲノム編集個体の作製~同一染色体二か所切断におけるノックイン個体作製の最適化~
(日本ゲノム編集学会第8回大会 2023)
多様化するゲノム編集の“今”
(日本ゲノム編集学会第8回大会 2023)
転写の活性化、抑制および DNA切断を同時制御するCRISPRaicシステムの開発
(日本ゲノム編集学会第8回大会 2023)
拡張型LoADシステムを用いたゲノム編集結果の制御技術の開発
(日本ゲノム編集学会第8回大会 2023)

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Education (4)：

2010 - 2012 Hiroshima University Graduate School of Science Department of Mathematical and Life Sciences
2008 - 2010 Hiroshima University Graduate School of Science Department of Biological Science
2006 - 2008 Hiroshima University Faculty of Science Departmet of Biological Science
2002 - 2006 Osaka University

Professional career (2)：

Doctor of Science (Ph.D.) (Hiroshima University)
Master of Science (Hiroshima University)

Work history (9)：

2024/04 - 現在 Regional Fish Institute, Ltd. CSO
2024/04 - 現在 Kyoto University Graduate School of Agriculture Program-Specific Professor
2023/04 - 2024/03 Hiroshima University Graduate School of Integrated Sciences for Life Professor
2020/04/01 - 2023/03/31 Hiroshima University Graduate School of Integrated Sciences for Life Associate Professor
2019/04 - 2020/03 Hiroshima University Graduate School of Integrated Sciences for Life Lecturer

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Committee career (11)：

2022/07 - 2024/06 (社)日本ゲノム編集学会教育実習委員会委員長
2022/07 - 2024/06 (社)日本ゲノム編集学会理事
2022/08 - 2023/07 プラチナバイオ株式会社科学技術顧問
2021/08 - 2022/07 プラチナバイオ株式会社科学技術顧問
2020/07 - 2022/06 (社)日本ゲノム編集学会理事

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Awards (6)：

2022 - Research.com Rising Star of Science Award
2021 - Hiroshima University Distinguished Researcher
2018 - Hiroshima University Distinguished Researcher
2017 - Hiroshima University Phoenix Outstanding Researcher Award
2016 - Hiroshima University Phoenix Outstanding Researcher Award

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Association Membership(s) (4)：

Japanese Cancer Association , Japanese Society of Developmental Biologists , The Molecular Biology Society of Japan , The Japanese Society for Genome Editing

※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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