Nonaka Motohiro

Affiliation and department：
Job title： Professor

Research field (3)： Tumor biology , Pharmaceuticals - health and biochemistry , Chemical biology

Research keywords (5)：アレルギー , 自己免疫疾患 , 悪性腫瘍標的ペプチド , ファージディスプレイ , 糖鎖生物学

Research theme for competitive and other funds (10)：

2022 - 2026 Development of mirror-image antibody-like scaffolds and their applications
2022 - 2024 Development of antibody-mimetic libraries by CDR grafting
2020 - 2023 分泌型ヘムタンパク質によるマクロファージの貪食抑制機構の解明
2020 - 2022 Development of Screening Platform for Mirror-image Antibody-like Scaffolds
2019 - 2022 Regulation of immune system by mimetic peptides

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Papers (34)：

Keisuke Aoki, Kayuu Maeda, Shinsuke Inuki, Hiroaki Ohno, Motohiro Nonaka, Shinya Oishi. Chemical Synthesis of Interleukin-6 for Mirror-Image Screening. Bioconjugate chemistry. 2024. 35. 8. 1190-1199
Keisuke Aoki, Katsuaki Higashi, Sakiho Oda, Asako Manabe, Kayuu Maeda, Jyoji Morise, Shogo Oka, Shinsuke Inuki, Hiroaki Ohno, Shinya Oishi, et al. Engineering a Low-Immunogenic Mirror-Image VHH against Vascular Endothelial Growth Factor. ACS chemical biology. 2024. 19. 5. 1194-1205
Katsuaki Higashi, Sakiho Oda, Mai Fujii, Fumiya Nishida, Hayato Matsumoto, Jyoji Morise, Shogo Oka, Motohiro Nonaka. Construction of a T7 phage random peptide library by combining seamless cloning with in vitro translation. Journal of biochemistry. 2023. 175. 1. 85-93
Keisuke Aoki, Asako Manabe, Hiroyuki Kimura, Yohei Katoh, Shinsuke Inuki, Hiroaki Ohno, Motohiro Nonaka, Shinya Oishi. Mirror-Image Single-Domain Antibody for a Novel Nonimmunogenic Drug Scaffold. Bioconjugate chemistry. 2023. 34. 11. 2055-2065
Naoya Iwamoto, Yukino Sato, Asako Manabe, Shinsuke Inuki, Hiroaki Ohno, Motohiro Nonaka, Shinya Oishi. Design and Synthesis of Monobody Variants with Low Immunogenicity. ACS medicinal chemistry letters. 2023. 14. 11. 1596-1601

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MISC (25)：

松本隼杜, 東克暁, 森瀬譲二, 岡昌吾, 野中元裕. NODマウスを用いた自己抗原エピトープ模倣ペプチドの取得. 日本生化学会大会(Web). 2023. 96th
東克暁, 小田幸穂, 森瀬譲二, 岡昌吾, 野中元裕. T7ファージライブラリーの新規作製法の開発. 日本生化学会大会(Web). 2023. 96th
野中元裕. 糖鎖ミメティクスを用いた、がんの治療法研究. Trends in Glycoscience and Glycotechnology. 2021. 33. 191-193. J1,E1-E4
Motohiro Nonaka. Carbohydrate mimetic peptides as anti-cancer therapeutics. Trends in Glycoscience and Glycotechnology. 2021. 33. 191. E1-E4
野中元裕. 糖鎖模倣ペプチドを用いた悪性脳腫瘍治療. 日本糖質学会年会要旨集. 2019. 38th

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Lectures and oral presentations (57)：

Identification of binding peptides against IgE from human myeloma U266 cells
(The 9th Japan-Korea Chemical Biology Symposium (Incheon, Korea) 2018)
Drug delivery to malignant brain tumor by a peptide specific to Annexin A1
(30th EORTC-NCI-AACR Symposium (Dublin, Ireland) 2018)
アレルギー疾患の化学療法を目指したファージディスプレイ戦略(奨励研究賞受賞講演)
(日本薬学会生薬天然物部会 2018)
糖鎖模倣ペプチドによる脳腫瘍治療
(第14回臨床糖鎖研究会 2018)
Identification of carbohydrate-mimetic D-amino acid peptides by peptide-display library screening as chemotherapy for malignant brain tumors
(Society for Glycobiology, annual meeting (Portland, USA) 2017)

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Education (3)：

Professional career (1)：

Work history (9)：

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Awards (2)：

2018/10 - 日本薬学会生薬天然物部会奨励研究賞
2007/07 - The International Glycoconjugate Organization Poster Award XIX International Symposium on Glycoconjugates

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