Sokabe Takaaki

Affiliation and department：
Job title： Associate Professor

Research field (4)： Animals: biochemistry, physiology, behavioral science , Neuroscience - general , Molecular biology , Cell biology

Research keywords (8)： sensory processes , temperature/mechanical sensation , Drosophila melanogaster , lipid , TRP channel , Insecticide, repellent , Behavioral analysis , Electrophsiology

Research theme for competitive and other funds (9)：

2021 - 2025 Identification of essential lipids for thermal responses and adaptation in Drosophila species
2018 - 2021 Identification of lipid regulatory genes important for membrane protein functions
2017 - 2019 Functional screening and analysis of lipid-related genes critical for temperature preference
2009 - 2010 カイコの季節戦略を規定する環境温度の受容と記憶に関わるセルセンサーの解明
2009 - 2010 温度感受性TRPチャネルの活性化メカニズムと構造-機能連関解明

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Papers (47)：

Kohei Ohnishi, Takaaki Sokabe, Toru Miura, Makoto Tominaga, Akane Ohta, Atsushi Kuhara. G protein-coupled receptor-based thermosensation determines temperature acclimatization of Caenorhabditis elegans. Nature communications. 2024. 15. 1. 1660-1660
Takuto SUITO, Kohjiro Nagao, Xiangmei Deng, Christian Ganser, Takayuki Uchihashi, Motosuke Tsutsumi, Tomomi Nemoto, Yuji Hara, Makoto Tominaga, Takaaki Sokabe. Ether phospholipids modulate somatosensory responses by tuning multiple receptor functions in Drosophila. 2023
Takaaki Sokabe, Heather B Bradshaw, Makoto Tominaga, Emma Leishman, Avinash Chandel, Craig Montell. Endocannabinoids produced in photoreceptor cells in response to light activate Drosophila TRP channels. Science signaling. 2022. 15. 755. eabl6179
Takuto Suito, Kohjiro Nagao, Naoto Juni, Yuji Hara, Takaaki Sokabe, Haruyuki Atomi, Masato Umeda. Regulation of thermoregulatory behavior by commensal bacteria in Drosophila. Bioscience, biotechnology, and biochemistry. 2022. 86. 8. 1060-1070
Takuto Suito, Kohjiro Nagao, Masahiro Kai, Naoto Juni, Takaaki Sokabe, Masato Umeda. Measurement of Thermoregulatory Behavior in Drosophila melanogaster. Neuromethods. 2022. 77-91

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MISC (6)：

Kunihiro Shiomi, Azusa Sato, Takaaki Sokabe, Makiko Kashio, Yuji Yasukochi, Yutaka Suzuki, Nozomi Yamamoto, Ken Kurokawa, Makoto Tominaga. Embryonic thermosensitive TRPA1 determines transgenerational diapause phenotype of the silkworm, Bombyx mori. GENES & GENETIC SYSTEMS. 2014. 89. 6. 298-298
藤田郁尚, 高石雅之, 内田邦敏, 曽我部隆彰, 富永真琴. 環境温度によるTRPM8の温度閾値はPIP₂の結合を介して変化する. 日本生理学雑誌. 2013. 75. 1
Fumitaka Fujita, Kunitoshi Uchida, Masayuki Takaishi, Takaaki Sokabe, Makoto Tominaga. Pre-exposed temperature affects temperature thresholds for TRPM8 activation through binding of phosphatidylinositol 4,5-bisphosphate. JOURNAL OF PHYSIOLOGICAL SCIENCES. 2013. 63. S195-S195
内田邦敏, 内田邦敏, 藤田郁尚, 森山朋子, 島麻子, 柴崎貢志, 柴崎貢志, 稲田仁, 曽我部隆彰, 富永真琴, et al. アルカリpHはTRPA1の活性化を介して痛みを引き起こす. 日本生理学雑誌. 2009. 71. 5
FUJITA Fumitaka, UCHIDA Kunitoshi, SHIBASAKI Koji, INADA Hitoshi, SOKABE Takaaki, TOMINAGA Makoto. TRPA1 as tools for the predictive identification of sensory irritation by alkali pH. 2008. 13. 201-201

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Patents (4)：

Education (1)：

2000 - 2004 The University of Tokyo Graduate School of Medicine

Work history (6)：

2018/04 - 現在自然科学研究機構生命創成探究センター温度生物学研究グループ准教授
2017/03 - 2018/03 自然科学研究機構生理学研究所/岡崎統合バイオサイエンスセンター細胞生理研究部門准教授
2013/04 - 2017/02 University of California, Santa Barbara Craig Montell's lab
2010/07 - 2013/03 Johns Hopkins University School of Medicine Craig Montell's lab
2005/04 - 2010/07 自然科学研究機構岡崎統合バイオサイエンスセンター細胞生理研究部門非常勤研究員/日本学術振興会特別研究員(PD)/特任助教

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Committee career (2)：

2022/10 - 現在 The Physiological Society of Japan A member of Physiology Educator System Certification Committee
2019/04 - 現在 The Physiological Society of Japan member of the Education Committee

Awards (5)：

2023/02 - 農芸化学会 2022年BBB論文賞 Regulation of thermoregulatory behavior by commensal bacteria in Drosophila.
2015/03 - 日本化粧品技術者会 2013-2014年SCCJ学会誌最優秀論文賞表皮バリア機能におけるTransient Receptor Potential Vanilloid 4 (TRPV4) の重要性.
2009/06 - 特定領域研究「細胞感覚」平成21年度班会議若手優秀発表賞温度感受性TRPチャネルの持つ機能多様性.
2008/09 - SciTechEdit International/Japan Neuroscience Society The 2nd annual Travel Award Drosophila painless is a noxious heat-activated, Ca2+-required channel.
2006/11 - International Symposium on Micro-NanoMechatronics and Human Science 優秀論文賞 Shear Stress Induces Hepatocyte PAI-1 Gene Expression Through Cooperative Sp1/Ets-1 Activation of Transcription.

Association Membership(s) (2)：

The Japan Neuroscience Society , The Physiological Society of Japan

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