Rchr
J-GLOBAL ID：201701019324954000
Update date: Feb. 01, 2024
Osamu Kminuma
カミヌマ オサム | Osamu Kminuma
Affiliation and department：
Job title：
教授
Research field (4)：
Molecular biology
, Pharmacology
, Immunology
, Laboratory animal science
Research theme for competitive and other funds (20)：
- 2022 - 2026 核移植クローン技術に基づく免疫応答・疾患発症機構の包括的研究基盤
- 2021 - 2024 Influence of branched-chain amino acid on the outcome in the acute ischemic stroke patients
- 2021 - 2024 腎細胞癌におけるBACH1機能解析を基礎とした抗PD-1抗体抵抗性獲得機序の解明
- 2021 - 2024 T細胞依存性遅発型喘息反応メディエータの解明
- 2020 - 2023 Basic research for new immunological therapies based on a pathological mechanism of periodontal disease
- 2019 - 2023 Usefulness of T cell cloned mice as bioresources for immunological science
- 2019 - 2022 Mechanism of suppression of mast cell degranulation by sublingual immunotherapy
- 2018 - 2021 Mechanisms underlying the development of hyperresponsiveness commonly induced by T cell subsets in allergic diseases
- 2018 - 2021 Investigation on steroid resistant airway inflammation
- 2018 - 2021 異なる遺伝子背景に起因する抗核抗体値上昇機構の解析
- 2018 - 2021 アレルギー疾患におけるT細胞サブセットに共通する過敏性亢進発症機構の解明
- 2016 - 2018 Elucidation of regeneration mechanism of digestive tract pacemaker cell by modified TRECK method
- 2015 - 2018 Elucidation of immune function through antigen-specific monoclonal T cell receptor
- 2015 - 2018 Elucidation of mechanism on neuronal cell death and development of hemodiagnosis in ischemic stroke
- 2015 - 2018 Development of diagnostic method for efficacy of sublingual immunotherapy based on systematic genome wide analysis
- 2015 - 2018 抗原特異的モノクローナルT細胞レセプターを介する免疫機構の解
- 2012 - 2015 Development of inducible and constitutive neutrophil-deficient mice for analyzing allergic inflammation
- 2012 - 2015 Development of a novel treatment for immunoregulation by analyzing specific regulatory mechanisms of the NFAT family.
- 2009 - 2011 Specific regulation for NFAT based on diversity of the NFAT family
- 2004 - 2004 転写因子による細胞系列の決定および維持の染色体制御機構
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Papers (121)：
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Keitaro Hayashi, Mayumi Saeki, Kento Miura, Norimasa Yamasaki, Masaya Matsuda, Hayato Shimora, Takeshi Nabe, Yasuo Shimizu, Tomoe Fujita, Hitoshi Endou, et al. JPH203, a LAT1 inhibitor, alleviates steroid-resistant murine airway inflammation mediated by Th17 cells. Allergy. 2023
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Norimasa Yamasaki, Kento Miura, Sawako Ogata, Shuka Miura, Arikuni Uchimura, Yasunari Satoh, Masaaki Toshishige, Naohisa Hosomi, Maribet Gamboa, Noriko Kitamura, et al. Generation of reporter mice for detecting the transcriptional activity of nuclear factor of activated T cells. Experimental animals. 2023
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神沼 修, 三浦 健人, 山崎 憲政, 尾形 佐和子, 三浦 舟華, 細見 直永, 中田 雄一郎, 後藤 穣. 制御性T細胞におけるニコチン性アセチルコリン受容体の発現と機能. 日本職業・環境アレルギー学会雑誌. 2023. 30. 1. 76-76
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Naoto Uda, Sawako Ogata, Norimasa Yamasaki, Shuka Miura, Naohisa Hosomi, Akio Mori, Minoru Gotoh, Kento Miura, Osamu Kaminuma. Re-evaluation of over-the-counter histamine H1-receptor antagonists based on their effects on murine models of allergen-induced nasal hyperresponsiveness. Journal of pharmacological sciences. 2022. 150. 4. 275-278
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Kenshiro Takemoto, Kohei Kobatake, Kento Miura, Takafumi Fukushima, Takashi Babasaki, Shunsuke Miyamoto, Yohei Sekino, Hiroyuki Kitano, Keisuke Goto, Kenichiro Ikeda, et al. BACH1 promotes clear cell renal cell carcinoma progression by upregulating oxidative stress-related tumorigenicity. Cancer science. 2022. 114. 2. 436-448
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MISC (39)：
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三浦健人, 佐伯真弓, 古山禎大, 山崎憲政, 尾形佐和子, 廣井隆親, 森晶夫, 神沼修. Th9細胞依存的なアレルギー性炎症は標的臓器間で異なるステロイド応答性を示す. アレルギー. 2021. 70. 6/7
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Kohei Kobatake, Ken-Ichiro Ikeda, Yuichiro Nakata, Norimasa Yamasaki, Takeshi Ueda, Akinori Kanai, Kazuhiro Sentani, Yasuyuki Sera, Tetsutaro Hayashi, Miho Koizumi, et al. Kdm6a Deficiency Activates Inflammatory Pathways, Promotes M2 Macrophage Polarization, and Causes Bladder Cancer in Cooperation with p53 Dysfunction. Clinical cancer research : an official journal of the American Association for Cancer Research. 2020. 26. 8. 2065-2079
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北村紀子, 神沼修, 神沼修. Usefulness and potential of isoform selective regulation of NFAT family transcription factors. 生化学. 2020. 92. 6
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佐伯真弓, 後藤穣, 後藤穣, 大久保公裕, 大久保公裕, 中谷明弘, 中谷明弘, 北村紀子, 西村友枝, 神沼修, et al. 舌下免疫療法における味覚受容体を介した奏功メカニズム. アレルギー. 2019. 68. 8
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Mayumi Saeki, Osamu Kaminuma, Tomoe Nishimura, Noriko Kitamura, Akio Mori, Takachika Hiroi. Th2 and Th9 cells induce airway eosinophilic inflammation by distinct mechanisms. CYTOKINE. 2017. 100. 135-135
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Lectures and oral presentations (12)：
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Silencing of the NFATc4 gene is crucial for cytokine production by T cells
(第47回日本免疫学会総会 2018)
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Functional diversity of NFAT family transcription factors
(第91回日本生化学会大会 2018)
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Pharmacological characterization of T cell-induced broncho-constriction in vitro and in vivo.
(ERS International Congress 2018 2018)
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Algorithmic prediction of responder and non-responder allergic rhinitis patients recieving sublingual immunotherapy
(18th World Congress of Basic and Clinical Pharmacology 2018)
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T細胞の核移植によるアレルギー疾患モデルマウス
(第55回筑波実験動物研究会講演会 2018)
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