Kanki Tomotake

カンキトモタケ | Kanki Tomotake

Affiliation and department：
Homepage URL (1)： https://www.med.niigata-u.ac.jp/mit/

Research field (3)： Pathobiochemistry , Medical biochemistry , Cell biology

Research keywords (3)： mitophagy , autophagy , mitochondria

Research theme for competitive and other funds (22)：

2024 - 2029 Genomic regulation of intracellular symbiotic organelles: from technological innovation to understanding and application of life phenomena
2022 - 2025 レセプター依存的マイトファジーの誘導制御と生理機能の解明
2019 - 2024 多様なマイトファジーの分子機構と生理的意義の解明
2019 - 2022 Proteins escape from autophagic degradation
2018 - 2020 マイトファジーレセプターAtg32のリン酸化制御機構の解明

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Papers (83)：

Kentaro Furukawa, Tamara Ginevskaia, Tomotake Kanki. Re-exploration of all ATG genes. Autophagy Reports. 2024. 3. 1
Tamara Ginevskaia, Aleksei Innokentev, Kentaro Furukawa, Tomoyuki Fukuda, Manabu Hayatsu, Shun-ichi Yamashita, Keiichi Inoue, Shinsuke Shibata, Tomotake Kanki. Comprehensive analysis of non-selective and selective autophagy in yeast atg mutants and characterization of autophagic activity in the absence of the Atg8 conjugation system. The Journal of Biochemistry. 2024
Kentaro Furukawa, Manabu Hayatsu, Kentaro Okuyama, Tomoyuki Fukuda, Shun-Ichi Yamashita, Keiichi Inoue, Shinsuke Shibata, Tomotake Kanki. Atg44/Mdi1/mitofissin facilitates Dnm1-mediated mitochondrial fission. Autophagy. 2024
Shun-Ichi Yamashita, Yuki Sugiura, Yuta Matsuoka, Rae Maeda, Keiichi Inoue, Kentaro Furukawa, Tomoyuki Fukuda, David C Chan, Tomotake Kanki. Mitophagy mediated by BNIP3 and NIX protects against ferroptosis by downregulating mitochondrial reactive oxygen species. Cell death and differentiation. 2024
Kyota Aoyagi, Chiyono Nishiwaki, Yoko Nakamichi, Shun-ichi Yamashita, Tomotake Kanki, Mica Ohara-Imaizumi. Imeglimin mitigates the accumulation of dysfunctional mitochondria to restore insulin secretion and suppress apoptosis of pancreatic β-cells from db/db mice. Scientific Reports. 2024. 14. 1

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MISC (16)：

山下俊一, 杉浦悠毅, 神吉智丈. ミトコンドリア機能の強靱化~そのメカニズムと介入操作~ ミトコンドリア分解欠損細胞に見られる酸化ストレス応答. 日本生化学会大会プログラム・講演要旨集. 2023. 96回. [3S01e-06]
古川健太郎, 神吉智丈. リン酸化が制御する出芽酵母のマイトファジー. 生化学. 2019. 91. 2. 224-227
山下俊一, 神吉智丈. 【オートファジーと疾患】ミトコンドリア恒常性の維持とマイトファジー. BIO Clinica. 2018. 33. 7. 617-621
CHERNYSHOVA Kseniia, CHERNYSHOVA Kseniia, 山下俊一, 五十嵐遼子, 五十嵐遼子, 福地健郎, 神吉智丈. 広義原発開放隅角緑内障の原因遺伝子オプチニューリン遺伝子の変異とミトコンドリア恒常性維持機構との関係. 日本緑内障学会抄録集. 2018. 29th
神吉智丈. 【オートファジーと疾患】 Parkinに依存しないマイトファジー. 最新医学. 2017. 72. 2. 205-210

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Books (2)：

Handbook of Famine, Starvation, and Nutrient Deprivation || Chapter 64-1
2017
AUTOPHAGY: Cancer, Other Pathologies, Inflammation, Immunity, and Infection Volume 4: Mitophagy
2014

Education (2)：

2000 - 2003 九州大学大学院医学研究科(博士(医学))
1991 - 1997 Kyushu University School of Medicine

Professional career (1)：

博士(医学) (九州大学)

Work history (9)：

2015/04 - 現在 Niigata University Graduate School of Medical and Dental Sciences
2012/07 - 2015/03 Niigata University Graduate School of Medical and Dental Sciences
2009/04 - 2012/06 九州大学病院検査部・助教
2007/04 - 2009/03 ミシガン大学博士研究員
2005/10 - 2007/03 Columbia University

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Awards (1)：

2012/04 - 文部科学省文部科学大臣表彰若手科学者賞

Association Membership(s) (6)：

酵母遺伝学フォーラム , THE JAPANESE SOCIETY OF MITOCHONDRIAL RESEARCH AND MEDICINE , JAPAN SOCIETY OF OBSTETRICS AND GYNECOLOGY , THE JAPANESE BIOCHEMICAL SOCIETY , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , JAPAN SOCIETY FOR CELL BIOLOGY

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