Art

J-GLOBAL ID：201702204401374395   Reference number：17A0976478

Orally administered p-nitrotoluene causes hyperactivity, concomitant with gliosis and impairment of tyrosine hydroxylase immunoreactivity in the rat substantia nigra

経口的に投与されるp-ニトロトルエンは運動亢進と同時にグリオーシスとラット黒質のチロシンヒドロキシラーゼの免疫反応の棄損を招く

Author (2)： Ishido Masami (Center for Health & Environmental Risk Research, National Institute for Environmental Studies) ,  Usu Rumiko (Center for Health & Environmental Risk Research, National Institute for Environmental Studies)
Material： Fundamental Toxicological Sciences (Web)  (Fundam Toxicol Sci (Web))
Volume： 4  Issue： 3  Page： 151-158(J-STAGE)  Publication year： 2017 
JST Material Number： U0596A  ISSN： 2189-115X  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *movement disorder ,...
Semi thesaurus term： glial fibrillary acidic protein ,...

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Author keywords (5)： p-Nitrotoluene ,  Hyperactivity ,  Neurodevelopmental disorder ,  Dopaminergic system ,  Gliosis

JST classification (2)： Basic neurology  (GN01020W) ,  Toxicity of inorganic compounds in general  (GZ02021E)

Substance index (1)： 4-Nitrotoluene

Reference (26)：

• Aso, S., Miyata, K., Ehara, H., Hosyuyama, S., Shiraishi, K., Umano, T. and Minobe, Y. (2005): A two-generation reproductive toxicity study of 4-nitrotoluene in rats. J. Toxicol. Sci., 30, 117-134.
• Borges, C.R., Geddes, T., Watson, J.T. and Kuhn, D.M. (2002): Dopamine biosynthesis is regulated by S-glutathionylation. J. Biol. Chem., 277, 48295-48302.
• Dunnick, J.K., Burka, L.T. and Sills, R. (2003): Carcinogenic potential of o-nitrotoluene and p-nitrotoluene. Toxicology, 183, 221-234.
• Gillberg, C. and Wing, L. (1999): Autism: not an extremely rare disorder. Acta Psychiatr. Scand., 99, 399-406.
• Goldman, L.S., Genel, M., Bezman, R.J. and Slanetz, P.J. (1998): Diagnosis and treatment of attention-deficit/hyperactivity disorder in children and adolescents. JAMA, 279, 1100-1107.

Terms in the title (8)： 投与 ,  p-ニトロトルエン ,  運動亢進 ,  グリオーシス ,  ラット ,  黒質 ,  チロシンヒドロキシラーゼ ,  免疫反応