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J-GLOBAL ID：201702212524837360   Reference number：17A0412458

Detection of dexmedetomidine in human breast milk using liquid chromatography-tandem mass spectrometry: Application to a study of drug safety in breastfeeding after Cesarean section

液体クロマトグラフィー-タンデム質量分析を用いたヒト母乳におけるデクスメデトミジンの検出:帝王切開後の授乳における薬物安全性の研究への応用【Powered by NICT】

Author (10)： Nakanishi Rika (Department of Oncology Pharmaceutical Care & Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1, Shikata-cho, Kita-ku, Okayama 700-8558, Japan) ,  Yoshimura Manabu (Department of Anesthesiology, Japan Community Healthcare Organization Tokuyama Central Hospital, 1-1 Kodacho, Shunan-City, Yamaguchi 745-8522, Japan) ,  Suno Manabu (Department of Oncology Pharmaceutical Care & Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1, Shikata-cho, Kita-ku, Okayama 700-8558, Japan) ,  Yamamoto Kento (Department of Oncology Pharmaceutical Care & Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1, Shikata-cho, Kita-ku, Okayama 700-8558, Japan) ,  Ito Haruka (Department of Oncology Pharmaceutical Care & Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1, Shikata-cho, Kita-ku, Okayama 700-8558, Japan) ,  Uchimine Yohei (Department of Oncology Pharmaceutical Care & Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1, Shikata-cho, Kita-ku, Okayama 700-8558, Japan) ,  Toriumi Takashi (Department of Anesthesiology, Japan Community Healthcare Organization Tokuyama Central Hospital, 1-1 Kodacho, Shunan-City, Yamaguchi 745-8522, Japan) ,  Kurosawa Atsushi (Department of Anesthesiology and Critical Care Medicine, Asahikawa Medical University, 2-1-1-1 Midorigaoka Higashi, Asahikawa, Hokkaido 078-8510, Japan) ,  Sugawara Ami (Department of Anesthesiology and Critical Care Medicine, Asahikawa Medical University, 2-1-1-1 Midorigaoka Higashi, Asahikawa, Hokkaido 078-8510, Japan) ,  Kunisawa Takayuki (Department of Anesthesiology and Critical Care Medicine, Asahikawa Medical University, 2-1-1-1 Midorigaoka Higashi, Asahikawa, Hokkaido 078-8510, Japan)
Material： Journal of Chromatography B  (Journal of Chromatography B. Analytical Technologies in the Biomedical and Life Sciences)
Volume： 1040  Page： 208-213  Publication year： 2017 
JST Material Number： W0571A  ISSN： 1570-0232  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Several analytical methods for...

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Thesaurus term： recovery rate ,  mobile phase ,  *human ,  *human milk ,  matrix effect ,  flow velocity ,  Plasma ,  robustness ,  high performance liquid chromatography ,  coefficient of variation ,  Liquid-Liquid Extraction ,  electrospray ionization ,  *Tandem Mass Spectrometry ,  lower limit of quantification ,  *liquid chromatography-tandem mass spectrometry
Semi thesaurus term： *LC/MS/MS , 【Automatic Indexing@JST】

Author keywords (5)： Dexmedetomidine ,  HPLC-MS/MS ,  Human breast milk ,  Breastfeeding ,  Relative infant dose

JST classification (1)： Miscellaneous analytical methods of organic compounds  (CC08034J)

Terms in the title (8)： 液体クロマトグラフィー-タンデム質量分析 ,  ヒト母乳 ,  デクスメデトミジン ,  帝王切開 ,  授乳 ,  薬物安全性 ,  研究 ,  応用