Art

J-GLOBAL ID：201702212564563652   Reference number：17A0518517

The Y54(L)W mutation of anti-leukotriene C₄ single-chain antibody increases affinity to leukotriene E₄

抗ロイコトリエンC₄一本鎖抗体のY54(L)W変異により,ロイコトリエンE₄への親和性を増強する

Author (16)： KAWAKAMI Yuki (Okayama Prefectural Univ., Okayama, JPN) ,  KINOSHITA Mai (Okayama Prefectural Univ., Okayama, JPN) ,  MORI Yoshiko (Okayama Prefectural Univ., Okayama, JPN) ,  OKOCHI Shuji (Okayama Prefectural Univ., Okayama, JPN) ,  HIRANO Shiori (Okayama Prefectural Univ., Okayama, JPN) ,  SHIMODA Ichika (Okayama Prefectural Univ., Okayama, JPN) ,  KANZAKI Keita (Okayama Prefectural Univ., Okayama, JPN) ,  SUZUKI-YAMAMOTO Toshiko (Okayama Prefectural Univ., Okayama, JPN) ,  KIMOTO Masumi (Okayama Prefectural Univ., Okayama, JPN) ,  SUGAHARA Mitsuaki (RIKEN, Hyogo, JPN) ,  HORI Tetsuya (RIKEN, Hyogo, JPN) ,  SAINO Hiromichi (Aoyama Gakuin Univ., Kanagawa, JPN) ,  MIYANO Masashi (RIKEN, Hyogo, JPN) ,  MIYANO Masashi (Aoyama Gakuin Univ., Kanagawa, JPN) ,  YAMAMOTO Shozo (Kyoto Women’s Univ., Kyoto, JPN) ,  TAKAHASHI Yoshitaka (Okayama Prefectural Univ., Okayama, JPN)
Material： Journal of Biochemistry  (JB)
Volume： 161  Issue： 1  Page： 79-86  Publication year： Jan. 2017 
JST Material Number： W1920A  ISSN： 0021-924X  CODEN： JOBIAO  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： *leukotriene ,...
Semi thesaurus term： Pichia ,...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=17A0518517&from=J-GLOBAL&jstjournalNo=W1920A") }}

JST classification (3)： Biochemistry of lipids in general  (EB05010B) ,  Biological function  (EB03040U) ,  Antigens,antibodies,complements in general  (ED04010A)

Substance index (1)： Leukotriene C4

Reference (31)：

• Samuelsson, B. (1983). Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation. Science 220, 568-575
• Liu, M. and Yokomizo, T. (2015). The role of leukotrienes in allergic diseases. Allergol. Int. 64, 17-26
• Yamamoto, S. (1992). Mammalian lipoxygenases: molecular structures and functions. Biochim. Biophys. Acta 1128, 117-131
• Radmark, O., Werz, O., Steinhilber, D., and Samuelsson, B. (2015). 5-Lipoxygenase, a key enzyme for leukotriene biosynthesis in health and disease. Biochim. Biophys. Acta 1851, 331-339
• Funk, C.D. (2001). Prostaglandins and leukotrienes: advances in eicosanoid biology. Science 294, 1871-1875

Terms in the title (6)： ロイコトリエンC4 ,  一本鎖抗体 ,  変異 ,  ロイコトリエンE4 ,  親和性 ,  増強