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J-GLOBAL ID：201702213154540531   Reference number：17A1234804

Ivermectin activates GIRK channels in a PIP₂-dependent, G_βγ-independent manner and an amino acid residue at the slide helix governs the activation

イベルメクチンはPIP_2依存性,G_βγ非依存的様式におけるGIRKチャンネルを活性化し,スライドヘリックスにおけるアミノ酸残基は活性化を支配する【Powered by NICT】

Author (10)： Chen I-Shan (Division of Biophysics and Neurobiology, Department of Molecular and Cellular Physiology, National Institute for Physiological Sciences, Okazaki, 444-8585, Japan) ,  Chen I-Shan (Department of Physiological Sciences, School of Life Science, SOKENDAI (The Graduate University for Advanced Studies), Hayama, 240-0193, Japan) ,  Tateyama Michihiro (Division of Biophysics and Neurobiology, Department of Molecular and Cellular Physiology, National Institute for Physiological Sciences, Okazaki, 444-8585, Japan) ,  Tateyama Michihiro (Department of Physiological Sciences, School of Life Science, SOKENDAI (The Graduate University for Advanced Studies), Hayama, 240-0193, Japan) ,  Fukata Yuko (Division of Membrane Physiology, Department of Molecular and Cellular Physiology, National Institute for Physiological Sciences, Okazaki, 444-8787, Japan) ,  Fukata Yuko (Department of Physiological Sciences, School of Life Science, SOKENDAI (The Graduate University for Advanced Studies), Hayama, 240-0193, Japan) ,  Uesugi Motonari (Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University, Uji, Kyoto, 611-0011, Japan) ,  Uesugi Motonari (Institute for Chemical Research, Kyoto University, Uji, Kyoto, 611-0011, Japan) ,  Kubo Yoshihiro (Division of Biophysics and Neurobiology, Department of Molecular and Cellular Physiology, National Institute for Physiological Sciences, Okazaki, 444-8585, Japan) ,  Kubo Yoshihiro (Department of Physiological Sciences, School of Life Science, SOKENDAI (The Graduate University for Advanced Studies), Hayama, 240-0193, Japan)
Material： Journal of Physiology  (J Physiol)
Volume： 595  Issue： 17  Page： 5895-5912  Publication year： 2017 
JST Material Number： C0587A  ISSN： 0022-3751  CODEN： JPHYA7  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： KEY POINTS: Ivermectin (IVM) i...

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Thesaurus term： Xenopus laevis ,  receptor ,  *amino acid residue ,  culture (biology) ,  mutagenesis ,  Oocytes ,  human ,  *channel ,  electric current ,  Ion Channels ,  subunit ,  Cytoplasm ,  Parasites ,  Ligands ,  *GIRK ,  Pipidae ,  Ion Transport ,  transportation ,  Biological Transport ,  transmembrane protein ,  ion transport(in vivo)

Author keywords (3)： GIRK channel ,  ivermectin ,  PIP2

JST classification (2)： Transport of cell membrane  (EF04020R) ,  Cell physiology in general  (EF02010S)

Terms in the title (7)： イベルメクチン ,  依存性 ,  様式 ,  GIRK ,  チャンネル ,  活性化 ,  アミノ酸残基