Art

J-GLOBAL ID：201702214287760088   Reference number：17A0650789

2-Aryl-5-carboxytetrazole as a New Photoaffinity Label for Drug Target Identification

薬物標的同定のための新しい光親和性標識としての2-アリール-5-カルボキシテトラゾール

Author (10)： HERNER Andras (State Univ. New York at Buffalo, New York, USA) ,  MARJANOVIC Jasmina (AbbVie Inc., Illinois, USA) ,  LEWANDOWSKI Tracey M. (State Univ. New York at Buffalo, New York, USA) ,  MARIN Violeta (AbbVie Inc., Illinois, USA) ,  PATTERSON Melanie (AbbVie Inc., Illinois, USA) ,  MIESBAUER Laura (AbbVie Inc., Illinois, USA) ,  READY Damien (AbbVie Inc., Illinois, USA) ,  WILLIAMS Jon (AbbVie Inc., Illinois, USA) ,  VASUDEVAN Anil (AbbVie Inc., Illinois, USA) ,  LIN Qing (State Univ. New York at Buffalo, New York, USA)
Material： Journal of the American Chemical Society  (J Am Chem Soc)
Volume： 138  Issue： 44  Page： 14609-14615  Publication year： Nov. 09, 2016 
JST Material Number： C0254A  ISSN： 0002-7863  CODEN： JACSAT  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *photoaffinity labeling ,  *target ,  *nitrogen heterocyclic compound ,  antitumor drug ,  Proteins ,  non-receptor tyrosine kinase ,  ultraviolet irradiation ,  in vitro experiment ,  *photocrosslinking ,  Tandem Mass Spectrometry ,  chemical reaction ,  in situ reaction ,  *Tetrazoles ,  bromodomain-containing protein 4 ,  *Drug target ,  enzyme inhibitor
Semi thesaurus term： BRD4 protein ,  Btk ,  *Drug target

JST classification (4)： Photochemical reactions  (CB08020F) ,  Labeled compounds  (CB10050N) ,  Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Other 6-membered rings with three or more hetero atoms  (CF07108D)

Substance index (13)： (S)-N-[2-[[4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-1-thia-5,7,8,9a-tetraaza-1H-cyclopenta[e]azulene-6β-yl]acetylamino]ethyl]-2-[(5-hexynoyl)amino]-4-(3-methyl-3H-diazirine-3-yl)butanamide ,  (S)-N-[2-[2-[2-[4-[6-[[5-[(2-Chloro-6-methylphenyl)carbamoyl]-2-thiazolyl]amino]-2-methyl-4-pyrimidinyl]-1-piperazinyl]ethoxy]ethoxy]ethyl]-2-[(5-hexynoyl)amino]-4-(3-methyl-3H-diazirine-3-yl)butanamide ,  (S)-N-[2-[4-[6-[[5-[(2-Chloro-6-methylphenyl)carbamoyl]-2-thiazolyl]amino]-2-methyl-4-pyrimidinyl]-1-piperazinyl]ethyl]-2-[(5-hexynoyl)amino]-4-(3-methyl-3H-diazirine-3-yl)butanamide ,  2-[4-[(3-Butynyl)carbamoylmethylamino]phenyl]-N-[2-[[4-(4-chlorophenyl)-2,3,9-trimethyl-6H-1-thia-5,7,8,9a-tetraaza-1H-cyclopenta[e]azulene-6β-yl]acetylamino]ethyl]-2H-tetrazole-5-carboxamide ,  2-[4-[(3-Butynyl)carbamoylmethylamino]phenyl]-N-[2-[2-[2-[[4-(4-chlorophenyl)-2,3,9-trimethyl-6H-1-thia-5,7,8,9a-tetraaza-1H-cyclopenta[e]azulene-6β-yl]acetylamino]ethoxy]ethoxy]ethyl]-2H-tetrazole-5-carboxamide ,  2-[4-[(3-Butynyl)carbamoylmethylamino]phenyl]-N-[2-[2-[2-[4-[6-[[5-[(2-chloro-6-methylphenyl)carbamoyl]-2-thiazolyl]amino]-2-methyl-4-pyrimidinyl]-1-piperazinyl]ethoxy]ethoxy]ethyl]-2H-tetrazole-5-carboxamide ,  2-[4-[(3-Butynyl)carbamoylmethylamino]phenyl]-N-[2-[4-[6-[[5-[(2-chloro-6-methylphenyl)carbamoyl]-2-thiazolyl]amino]-2-methyl-4-pyrimidinyl]-1-piperazinyl]ethyl]-2H-tetrazole-5-carboxamide ,  JQ-1 ,  N-[2-[[4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-1-thia-5,7,8,9a-tetraaza-1H-cyclopenta[e]azulene-6β-yl]acetylamino]ethyl]-4-[4-(4-pentynyloxy)benzoyl]benzamide ,  N-[2-[2-[2-[[4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-1-thia-5,7,8,9a-tetraaza-1H-cyclopenta[e]azulene-6β-yl]acetylamino]ethoxy]ethoxy]ethyl]-4-[4-(4-pentynyloxy)benzoyl]benzamide ,  N-[2-[2-[2-[4-[6-[[5-[(2-Chloro-6-methylphenyl)carbamoyl]-2-thiazolyl]amino]-2-methyl-4-pyrimidinyl]-1-piperazinyl]ethoxy]ethoxy]ethyl]-4-[4-(4-pentynyloxy)benzoyl]benzamide ,  N-[2-[4-[6-[[5-[(2-Chloro-6-methylphenyl)carbamoyl]-2-thiazolyl]amino]-2-methyl-4-pyrimidinyl]-1-piperazinyl]ethyl]-4-[4-(4-pentynyloxy)benzoyl]benzamide ,  Dasatinib

Terms in the title (3)： 薬物標的 ,  同定 ,  光親和性標識