Art

J-GLOBAL ID：201702216140485222   Reference number：17A0979756

Disease model discovery from 3,328 gene knockouts by The International Mouse Phenotyping Consortium

疾患モデル:国際マウス表現型解析コンソーシアムが3,328遺伝子のノックアウトマウスから疾患モデルを発見

Author (74)： MEEHAN Terrence F (European Molecular Biology Lab., Hinxton, GBR) ,  CONTE Nathalie (European Molecular Biology Lab., Hinxton, GBR) ,  MASON Jeremy (European Molecular Biology Lab., Hinxton, GBR) ,  WARREN Jonathan (European Molecular Biology Lab., Hinxton, GBR) ,  CHEN Chao-Kung (European Molecular Biology Lab., Hinxton, GBR) ,  TUDOSE Ilinca (European Molecular Biology Lab., Hinxton, GBR) ,  RELAC Mike (European Molecular Biology Lab., Hinxton, GBR) ,  MATTHEWS Peter (European Molecular Biology Lab., Hinxton, GBR) ,  FLICEK Paul (European Molecular Biology Lab., Hinxton, GBR) ,  PARKINSON Helen (European Molecular Biology Lab., Hinxton, GBR) ,  WEST David B (Children’s Hospital Oakland Res. Inst., California, USA) ,  JACOBSEN Julius O (Queen Mary Univ. London, London, GBR) ,  SMEDLEY Damian (Queen Mary Univ. London, London, GBR) ,  KARP Natasha (Wellcome Trust Sanger Inst., Hinxton, GBR) ,  WHITE Jacqueline K (Wellcome Trust Sanger Inst., Hinxton, GBR) ,  BRADLEY Allan (Wellcome Trust Sanger Inst., Hinxton, GBR) ,  SKARNES William C (Wellcome Trust Sanger Inst., Hinxton, GBR) ,  ADAMS David J (Wellcome Trust Sanger Inst., Hinxton, GBR) ,  SANTOS Luis (Medical Res. Council Harwell, Harwell, GBR) ,  FIEGEL Tanja (Medical Res. Council Harwell, Harwell, GBR) ,  RING Natalie (Medical Res. Council Harwell, Harwell, GBR) ,  WESTERBERG Henrik (Medical Res. Council Harwell, Harwell, GBR) ,  GREENAWAY Simon (Medical Res. Council Harwell, Harwell, GBR) ,  SNEDDON Duncan (Medical Res. Council Harwell, Harwell, GBR) ,  MORGAN Hugh (Medical Res. Council Harwell, Harwell, GBR) ,  CODNER Gemma F (Medical Res. Council Harwell, Harwell, GBR) ,  STEWART Michelle E (Medical Res. Council Harwell, Harwell, GBR) ,  BROWN James (Medical Res. Council Harwell, Harwell, GBR) ,  HORNER Neil (Medical Res. Council Harwell, Harwell, GBR) ,  WELLS Sara (Medical Res. Council Harwell, Harwell, GBR) ,  MALLON Ann-Marie (Medical Res. Council Harwell, Harwell, GBR) ,  BROWN Steve D M (Medical Res. Council Harwell, Harwell, GBR) ,  HAENDEL Melissa (Oregon Health & Sci. Univ., Oregon, USA) ,  WASHINGTON Nicole (Lawrence Berkeley National Lab., California, USA) ,  MUNGALL Christopher J (Lawrence Berkeley National Lab., California, USA) ,  REYNOLDS Corey L (Baylor Coll. of Medicine, Texas, USA) ,  GALLEGOS Juan (Baylor Coll. of Medicine, Texas, USA) ,  SEAVITT John (Baylor Coll. of Medicine, Texas, USA) ,  BEAUDET Arthur L (Baylor Coll. of Medicine, Texas, USA) ,  DICKINSON Mary E (Baylor Coll. of Medicine, Texas, USA) ,  GAILUS-DURNER Valerie (German Res. Center for Environmental Health, Neuherberg, DEU) ,  WURST Wolfgang (German Res. Center for Environmental Health, Neuherberg, DEU) ,  DE ANGELIS Martin Hrabe (German Res. Center for Environmental Health, Neuherberg, DEU) ,  SORG Tania (Inst. Clinique de la Souris (ICS), Illkirch-Graffenstaden, FRA) ,  PAVLOVIC Guillaume (Inst. Clinique de la Souris (ICS), Illkirch-Graffenstaden, FRA) ,  HERAULT Yann (Inst. Clinique de la Souris (ICS), Illkirch-Graffenstaden, FRA) ,  SORG Tania (Univ. de Strasbourg, Illkirch, FRA) ,  PAVLOVIC Guillaume (Univ. de Strasbourg, Illkirch, FRA) ,  HERAULT Yann (Univ. de Strasbourg, Illkirch, FRA) ,  SORG Tania (UMR7104, Centre National de la Rech. Scientifique, Illkirch, FRA) ,  PAVLOVIC Guillaume (UMR7104, Centre National de la Rech. Scientifique, Illkirch, FRA) ,  HERAULT Yann (UMR7104, Centre National de la Rech. Scientifique, Illkirch, FRA) ,  SORG Tania (Inst. National de la Sante et de la Rech. Medicale, Illkirch, FRA) ,  PAVLOVIC Guillaume (Inst. National de la Sante et de la Rech. Medicale, Illkirch, FRA) ,  HERAULT Yann (Inst. National de la Sante et de la Rech. Medicale, Illkirch, FRA) ,  BOWER Lynette R (Univ. California, Davis, California, USA) ,  LLOYD K C Kent (Univ. California, Davis, California, USA) ,  MOORE Mark (IMPC, California, USA) ,  MORSE Iva (Charles River Lab., Massachusetts, USA) ,  GAO Xiang (Nanjing Univ., Nanjing, CHN) ,  TOCCHINI-VALENTINI Glauco P (Inst. of Cell Biology and Neurobiology, Italian National Res. Council (CNR), Monterotondo Scalo, ITA) ,  OBATA Yuichi (RIKEN BioResource Center, Tsukuba, JPN) ,  CHO Soo Young (Korea Mouse Phenotyping Center, Seoul, KOR) ,  SEONG Je Kyung (Korea Mouse Phenotyping Center, Seoul, KOR) ,  CHO Soo Young (National Cancer Center, Goyang, KOR) ,  SEONG Je Kyung (Seoul National Univ., Seoul, KOR) ,  FLENNIKEN Ann M (Centre for Phenogenomics, Ontario, CAN) ,  NUTTER Lauryl M J (Centre for Phenogenomics, Ontario, CAN) ,  NEWBIGGING Susan (Centre for Phenogenomics, Ontario, CAN) ,  MCKERLIE Colin (Centre for Phenogenomics, Ontario, CAN) ,  JUSTICE Monica J (Hospital for Sick Children, Ontario, CAN) ,  MURRAY Stephen A (Jackson Lab., Maine, USA) ,  SVENSON Karen L (Jackson Lab., Maine, USA) ,  BRAUN Robert E (Jackson Lab., Maine, USA)
Material： Nature Genetics  (Nat Genet)
Volume： 49  Issue： 8  Page： 1231-1238  Publication year： Aug. 2017 
JST Material Number： W0430A  ISSN： 1061-4036  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： international organization ,  *knockout mouse ,  genome ,  *molecular genetic phenomenon ,  *phenotype ,  *gene ,  *experimental disease ,  mutant ,  blood coagulation disorder ,  blood platelet disorder ,  congenital disease ,  hypothalamic disease ,  multiple abnormality ,  ventricular tachycardia ,  congenital heart disease ,  *hereditary disease
Semi thesaurus term： Bardet-Biedl Syndrome ,  Bernard-Soulier Syndrome ,  Gordon Holmes症候群 ,  *animal models of human disease ,  *gene function ,  国際マウス表現型コンソーシアム ,  disease model ,  *disease-related gene ,  Arrhythmogenic Right Ventricular Dysplasia ,  *Mendelian disorder ,  candidate gene

JST classification (2)： Congenital diseases,deformities in general.  (GD03010V) ,  Structure and chemistry of genes  (EC02020U)

Terms in the title (7)： 疾患モデル ,  マウス ,  表現型解析 ,  コンソーシアム ,  遺伝子 ,  ノックアウトマウス ,  発見