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J-GLOBAL ID：201702217481665794   Reference number：17A1493000

Improved Intravitreal AAV-Mediated Inner Retinal Gene Transduction after Surgical Internal Limiting Membrane Peeling in Cynomolgus Monkeys

カニクイザルにおける手術内境界膜剥離後に改善された硝子体内A AV介在の網膜内層遺伝子導入【Powered by NICT】

Author (15)： Takahashi Kazuhisa (Department of Biochemistry and Molecular Biology, Nippon Medical School, Tokyo 113-8602 Japan) ,  Takahashi Kazuhisa (Department of Ophthalmology, Nippon Medical School, Tokyo 113-8602, Japan) ,  Igarashi Tsutomu (Department of Biochemistry and Molecular Biology, Nippon Medical School, Tokyo 113-8602 Japan) ,  Igarashi Tsutomu (Department of Ophthalmology, Nippon Medical School, Tokyo 113-8602, Japan) ,  Miyake Koichi (Department of Biochemistry and Molecular Biology, Nippon Medical School, Tokyo 113-8602 Japan) ,  Kobayashi Maika (Department of Ophthalmology, Nippon Medical School, Tokyo 113-8602, Japan) ,  Yaguchi Chiemi (Department of Ophthalmology, Nippon Medical School, Tokyo 113-8602, Japan) ,  Iijima Osamu (Department of Biochemistry and Molecular Biology, Nippon Medical School, Tokyo 113-8602 Japan) ,  Yamazaki Yoshiyuki (Department of Biochemistry and Molecular Biology, Nippon Medical School, Tokyo 113-8602 Japan) ,  Katakai Yuko (The Corporation for Production and Research of Laboratory Primates, Ibaraki 305-0843, Japan) ,  Miyake Noriko (Department of Biochemistry and Molecular Biology, Nippon Medical School, Tokyo 113-8602 Japan) ,  Kameya Shuhei (Department of Ophthalmology, Nippon Medical School, Chiba Hokusoh Hospital, Chiba 270-1694, Japan) ,  Shimada Takashi (Department of Biochemistry and Molecular Biology, Nippon Medical School, Tokyo 113-8602 Japan) ,  Takahashi Hiroshi (Department of Ophthalmology, Nippon Medical School, Tokyo 113-8602, Japan) ,  Okada Takashi (Department of Biochemistry and Molecular Biology, Nippon Medical School, Tokyo 113-8602 Japan)
Material： Molecular Therapy  (Mol Ther)
Volume： 25  Issue： 1  Page： 296-302  Publication year： 2017 
JST Material Number： W1762A  ISSN： 1525-0016  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： The retina is an ideal target ...

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Thesaurus term： *vitreous body ,  human ,  serotype ,  transduction ,  vector (genetics) ,  *Retina ,  Gene Therapy ,  *Macaca fascicularis ,  *gene introduction ,  Safety ,  retinal disease ,  adeno-associated virus ,  *inner limiting membrane ,  Genetic Variation ,  *monkey and ape ,  microorganism
Semi thesaurus term： variation(biology) ,  *内境界膜剥離術 , 【Automatic Indexing@JST】

Author keywords (6)： triple-mutated AAV ,  intravitreous injection ,  cynomolgus ,  internal limiting membrane ,  glaucoma ,  retina

JST classification (1)： Gene manipulation  (EC02050B)

Terms in the title (7)： カニクイザル ,  手術 ,  内境界膜剥離 ,  硝子体 ,  網膜 ,  内層 ,  遺伝子導入