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J-GLOBAL ID：201702218693975959   Reference number：17A0565777

Significance of Stat3 Signaling in Epithelial Cell Differentiation of Fetal Mouse Lungs

マウス胎児の肺の上皮細胞分化にけるStat3シグナリングの重要性

Author (6)： Kameyama Hiroki (Department of Pathology and Experimental Medicine, Kumamoto University Graduate School of Medical Sciences) ,  Kameyama Hiroki (Division of Pathology, Kumamoto Health Science University) ,  Kudoh Shinji (Department of Pathology and Experimental Medicine, Kumamoto University Graduate School of Medical Sciences) ,  Hatakeyama Jun (Department of Brain Morphogenesis, Institute of Molecular Embryology and Genetics, Kumamoto University) ,  Matuo Akira (Department of Pathology and Experimental Medicine, Kumamoto University Graduate School of Medical Sciences) ,  Ito Takaaki (Department of Pathology and Experimental Medicine, Kumamoto University Graduate School of Medical Sciences)
Material： Acta Histochemica et Cytochemica (Web)  (Acta Histochem Cytochem (Web))
Volume： 50  Issue： 1  Page： 1-9(J-STAGE)  Publication year： 2017 
JST Material Number： U0129A  ISSN： 1347-5800  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： mouse(animal) ,...
Semi thesaurus term： Clara cell ,...

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Author keywords (5)： Stat3 ,  Hes1 ,  Clara cell ,  ciliated cell ,  neuroendocrine cell

JST classification (2)： Cell physiology in general  (EF02010S) ,  Lung  (EJ05020K)

Substance index (1)： Cucurbitacin I

Reference (30)：

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• 2 Blaskovich, M. A., Sun, J., Cantor, A., Turkson, J., Jove, R. and Sebti, S. M. (2003) Discovery of JSI-124 (cucurbitacin I), a selective janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice. Cancer Res. 63; 1270-1279.
• 3 Gaillard, D. and Puchelle, E. (1999) Differentiation and maturation of airway epithelial cells: Role of extracellular matrix and growth factors. In “Lung Development”, ed. by C. Gaultier, J. Bourbon and M. Post. Springer, New York, pp. 46-76.
• 4 Gurusamy, D., Ruiz-Torres, S. J., Johnson, A. L., Smith, D. A. and Waltz, S. E. (2014) Hepatocyte growth factor-like protein is a positive regulator of early mammary gland ductal morphogenesis. Mech. Dev. 133; 11-22.
• 5 Hirano, T. (1998) Interleukin 6 and its receptor: Ten years later. Int. Rev. Immunol. 16; 249-284.

Terms in the title (8)： マウス ,  胎児 ,  肺 ,  上皮細胞 ,  分化 ,  STAT3 ,  シグナリング ,  重要性