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J-GLOBAL ID：201702218821231900   Reference number：17A0870333

Haptoglobin Reduces Inflammatory Cytokine INF-γ and Facilitates Clot Formation in Acute Severe Burn Rat Model

ハプトグロビンは急性重症火傷ラットモデルにおいて炎症性サイトカインであるINF-γを低下させて血餅形成を促進する

Author (8)： Koami Hiroyuki (Department of Emergency and Critical Care Medicine, Faculty of Medicine, Saga University) ,  Sakamoto Yuichiro (Department of Emergency and Critical Care Medicine, Faculty of Medicine, Saga University) ,  Miyasho Taku (Department of Veterinary Science, School of Veterinary Medicine, Rakuno Gakuen University) ,  Noguchi Ryo (Department of Thoracic and Cardiovascular Surgery, Faculty of Medicine, Saga University) ,  Sato Norio (Department of Primary Care & Emergency Medicine, Faculty of Medicine, Kyoto University) ,  Kai Keita (Department of Pathology, Saga University Hospital) ,  Chris Yamada Kosuke (Department of Emergency and Critical Care Medicine, Faculty of Medicine, Saga University) ,  Inoue Satoshi (Division of Trauma Surgery and Surgical Critical Care, Faculty of Medicine, Saga University)
Material： Journal of Nippon Medical School  (日本医科大学雑誌)
Volume： 84  Issue： 2  Page： 64-72(J-STAGE)  Publication year： 2017 
JST Material Number： F0887A  ISSN： 1345-4676  CODEN： JNMSF5  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *haptoglobin ,...

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Author keywords (5)： haptoglobin ,  severe burn ,  IFN-γ ,  clot formation ,  thromboelastometry

JST classification (1)： Biological function  (EB03040U)

Reference (38)：

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• 2. Moestrup SK, Moller HJ: CD163: a regulated hemoglobin scavenger receptor with a role in the anti-inflammatory response. Ann Med 2004; 36: 347-354.
• 3. Baek JH, D'Agnillo F, Vallelian F, Pereira CP, Williams MC, Jia Y, Schaer DJ, Buehler PW: Hemoglobin-driven pathophysiology is an in vivo consequence of the red blood cell storage lesion that can be attenuated in guinea pigs by haptoglobin therapy. J Clin Invest 2012; 122: 1444-1458.
• 4. Ohshiro TU, Mukai K, Kosaki G: Prevention of hemoglobinuria by administration of haptoglobin. Res Exp Med (Berl) 1980; 177: 1-12.
• 5. Duan X, Yarmush DM, Jayaraman A, Yarmush ML: Dispensable role for interferon-gamma in the burn-induced acute phase response: a proteomic analysis. Proteomics 2004; 4: 1830-1839.

Terms in the title (8)： ハプトグロビン ,  重症 ,  火傷 ,  ラット ,  モデル ,  炎症性サイトカイン ,  血餅 ,  促進