Art

J-GLOBAL ID：201702219593702413   Reference number：17A0619700

Cilostazol protects against microvascular brain injury in a rat model of type 2 diabetes

シロスタゾールは,2型糖尿病のラットモデルにおける微小血管脳損傷から保護する

Author (9)： Tsukamoto Yuko (Department of Neurology, Tokai University School of Medicine, 143 Shimo-Kasuya, Isehara, Kanagawa, 259-1193, Japan) ,  Nagata Eiichiro (Department of Neurology, Tokai University School of Medicine, 143 Shimo-Kasuya, Isehara, Kanagawa, 259-1193, Japan) ,  Fukuyama Naoto (Department of Physiology, Tokai University School of Medicine, 143 Shimo-Kasuya, Isehara, Kanagawa, 259-1193, Japan) ,  Itoh Yoshiko (Support Center for Medical Research and Education, Tokai University, 143 Shimo-Kasuya, Isehara, Kanagawa, 259-1193, Japan) ,  Yuzawa Hiroko (Department of Neurology, Tokai University School of Medicine, 143 Shimo-Kasuya, Isehara, Kanagawa, 259-1193, Japan) ,  Kohara Saori (Department of Neurology, Tokai University School of Medicine, 143 Shimo-Kasuya, Isehara, Kanagawa, 259-1193, Japan) ,  Shimizu Mie (Department of Neurology, Tokai University School of Medicine, 143 Shimo-Kasuya, Isehara, Kanagawa, 259-1193, Japan) ,  Takahari Yoko (Support Center for Medical Research and Education, Tokai University, 143 Shimo-Kasuya, Isehara, Kanagawa, 259-1193, Japan) ,  Takizawa Shunya (Department of Neurology, Tokai University School of Medicine, 143 Shimo-Kasuya, Isehara, Kanagawa, 259-1193, Japan)
Material： Neuroscience Research  (神経科学)
Volume： 117  Page： 48-53  Publication year： Apr. 2017 
JST Material Number： D0210C  ISSN： 0168-0102  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： rat ,...
Semi thesaurus term： Neuroprotection ,...

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Author keywords (4)： Cilostazol ,  Diabetes mellitus ,  Endothelial cell function ,  Microangiography

JST classification (1)： Basic neurology  (GN01020W)

Substance index (1)： Cilostazol

Reference (22)：

• Aoki, Y., Shimizu, M., Watanabe, N., 2014. The blood glucose level increased in parallel with heart rate following cilostazol administration in three diabetic patients. Intern. Med. 53, 859-863.
• Biscetti, F., Ferraccioli, G., 2015. New therapeutic effects of cilostazol in patients with ischemic disorders. Curr. Vasc. Pharmacol. 13, 399-404.
• Biscetti, F., Pecorini, G., Straface, G., Arena, V., Stigliano, E., Rutella, S., Locatelli, F., Angelini, F., Ghirlanda, G., Flex, A., 2013. Cilostazol promotes angiogenesis after peripheral ischemia through a VEGF-dependent mechanism. Int. J. Cardiol. 167, 910-916.
• Chistiakov, D.A., Ashwell, K.W., Orekhov, A.N., Bobryshev, Y.V., 2015. Innervation of the arterial wall and its modification in atherosclerosis. Auton. Neurosci. 193, 7-11.
• Fukuyama, N., Tsukamoto, Y., Takizawa, S., Ikeya, Y., Fujii, T., Shinozaki, Y., Takahari, Y., Kawabe, N., Wakana, N., Umetani, K., Todoroki, K., Fukui, S., Tanaka, C., Tanaka, E., Mori, H., 2015. Altered blood flow in cerebral perforating arteries of rat models of diabetes: a synchrotron radiation microangiographic study toward clinical evaluation of white matter hyperintensities. Geriatr. Gerontol. Int. 15, 74-80.

Terms in the title (6)： シロスタゾール ,  2型糖尿病 ,  ラット ,  モデル ,  微小血管 ,  脳損傷