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J-GLOBAL ID：201702219782611243   Reference number：17A0648991

Biodistribution of diphenhydramine in reproductive organs in an overdose case

過量投与症例の生殖器におけるジフェンヒドラミンの生体内分布

Author (9)： ORITANI Shigeki (Osaka City Univ. Medical School, Osaka, JPN) ,  MICHIUE Tomomi (Osaka City Univ. Medical School, Osaka, JPN) ,  MICHIUE Tomomi (Medico-legal Consultation and Postmortem Investigation Support Center, Osaka, JPN) ,  CHEN Jian-Hua (Osaka City Univ. Medical School, Osaka, JPN) ,  CHEN Jian-Hua (Medico-legal Consultation and Postmortem Investigation Support Center, Osaka, JPN) ,  TANI Naoto (Osaka City Univ. Medical School, Osaka, JPN) ,  TANI Naoto (Medico-legal Consultation and Postmortem Investigation Support Center, Osaka, JPN) ,  ISHIKAWA Takaki (Osaka City Univ. Medical School, Osaka, JPN) ,  ISHIKAWA Takaki (Medico-legal Consultation and Postmortem Investigation Support Center, Osaka, JPN)
Material： Human Cell (Web)  (Hum Cell (Web))
Volume： 30  Issue： 2  Page： 106-116 (WEB ONLY)  Publication year： Apr. 2017 
JST Material Number： U0492A  ISSN： 1749-0774  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Thesaurus term： human(primates) ,...
Semi thesaurus term： *preventive agent for motion sickness ,...

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JST classification (2)： Basic research of drugs acting on digestive system  (GW09010Q) ,  Clinical biopharmacy  (GY01022L)

Substance index (4)： Caffeine ,  Diphyllin ,  Diphenidol hydrochloride ,  Diphenhydramine

Reference (59)：

• Simons FER. Advances in H1-antihistamines. N Engl J Med. 2004;351:2203-17.
• Nine JS, Rund CR. Fatality from diphenhydramine monointoxication: a case report and review of the infant, pediatric, and adult literature. Am J Forensic Med Pathol. 2006;27:36-41.
• Church MK, Maurer M, Simons FER, Global allergy and asthma European network, et al. Risk of first-generation H(1)-antihistamines: a GA(2)LEN position paper. Allergy. 2010;65:459-66.
• Scavone JM, Luna BG, Harmatz JS, von Moltke L, Greenblatt DJ. Diphenhydramine kinetics following intravenous, oral, and sublingual dimenhydrinate administration. Biopharm Drug Dispos. 1990;11:185-9.
• Estelle F, Simons R. H1-receptor antagonists: safety issues. Ann Allergy Asthma Immunol. 1999;83:481-8.

Terms in the title (5)： 過量投与 ,  症例 ,  生殖器 ,  ジフェンヒドラミン ,  生体内分布