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J-GLOBAL ID：201702222001588199   Reference number：17A1452391

WP1066, a small molecule inhibitor of the JAK/STAT3 pathway, inhibits ceramide glucosyltransferase activity

JAK/STAT3経路の小分子阻害剤,WP1066はセラミドグルコシルトランスフェラーゼ活性を阻害する【Powered by NICT】

Author (7)： Tsurumaki Hirotaka (Laboratory for Animal Cell Engineering, Niigata University of Pharmacy and Applied Life Sciences (NUPALS), 265-1 Higashijima, Akiha-ku, Niigata-shi, Niigata 956-8603, Japan) ,  Katano Hikaru (Laboratory for Animal Cell Engineering, Niigata University of Pharmacy and Applied Life Sciences (NUPALS), 265-1 Higashijima, Akiha-ku, Niigata-shi, Niigata 956-8603, Japan) ,  Sato Kousuke (Laboratory for Animal Cell Engineering, Niigata University of Pharmacy and Applied Life Sciences (NUPALS), 265-1 Higashijima, Akiha-ku, Niigata-shi, Niigata 956-8603, Japan) ,  Imai Ryou (Laboratory for Animal Cell Engineering, Niigata University of Pharmacy and Applied Life Sciences (NUPALS), 265-1 Higashijima, Akiha-ku, Niigata-shi, Niigata 956-8603, Japan) ,  Niino Satomi (Laboratory for Animal Cell Engineering, Niigata University of Pharmacy and Applied Life Sciences (NUPALS), 265-1 Higashijima, Akiha-ku, Niigata-shi, Niigata 956-8603, Japan) ,  Hirabayashi Yoshio (Laboratory for Molecular Membrane Neuroscience, Brain Science Institute (BSI), The Institute of Physical and Chemical Research (RIKEN), 2-1 Hirosawa, Wako-shi, Saitama 351-01, Japan) ,  Ichikawa Shinichi (Laboratory for Animal Cell Engineering, Niigata University of Pharmacy and Applied Life Sciences (NUPALS), 265-1 Higashijima, Akiha-ku, Niigata-shi, Niigata 956-8603, Japan)
Material： Biochemical and Biophysical Research Communications  (BBRC)
Volume： 491  Issue： 2  Page： 265-270  Publication year： 2017 
JST Material Number： B0118A  ISSN： 0006-291X  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： WP1066 is a well-known inhibit...

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Thesaurus term： Glycosylation ,  enzyme ,  catalyst ,  Proteins ,  *sphingoglycolipid ,  *STAT3 Transcription Factor ,  signal transduction pathway
Semi thesaurus term： *阻害剤 ,  伝達経路 ,  *小分子阻害剤 , 【Automatic Indexing@JST】

Author keywords (4)： Glucosylceramide ,  Inhibitor ,  STAT3 ,  Cell death

JST classification (1)： Cell physiology in general  (EF02010S)

Terms in the title (6)： JAK ,  STAT3 ,  経路 ,  小分子阻害剤 ,  活性 ,  阻害