Art

J-GLOBAL ID：201702222121140588   Reference number：17A1697865

Glibenclamide inhibits NLRP3 inflammasome-mediated IL-1β secretion in human trophoblasts

グリベンクラミドは,ヒトトロホブラストでNLRP3インフラマソーム仲介IL-1β分泌を阻害する

Author (7)： Tamura Kazuhiro (Department of Endocrine & Neural Pharmacology, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan) ,  Ishikawa Gen (Department of Obstetrics and Gynecology, Nippon Medical School, 1-7-1, Nagayama, Tokyo 160-0023, Japan) ,  Yoshie Mikihiro (Department of Endocrine & Neural Pharmacology, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan) ,  Ohneda Wakana (Department of Endocrine & Neural Pharmacology, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan) ,  Nakai Akihito (Department of Obstetrics and Gynecology, Nippon Medical School, 1-7-1, Nagayama, Tokyo 160-0023, Japan) ,  Takeshita Toshiyuki (Department of Obstetrics and Gynecology, Nippon Medical School, 1-1-5, Bunkyo, Tokyo 113-8603, Japan) ,  Tachikawa Eiichi (Department of Endocrine & Neural Pharmacology, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan)
Material： Journal of Pharmacological Sciences (Web)  (J Pharmacol Sci (Web))
Volume： 135  Issue： 2  Page： 89-95  Publication year： 2017 
JST Material Number： U0667A  ISSN： 1347-8613  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： antiarrhythmic drug ,...
Semi thesaurus term： NLRP3 ,...

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Author keywords (5)： Inflammasome ,  TLR4 ,  NLRP3 ,  Caspase-1 ,  Trophoblast

JST classification (3)： Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W) ,  Basic gynecology and obstetrics  (GS01020L) ,  Immunological reaction in general  (ED03010T)

Substance index (3)： Glibenclamide ,  Y-27632 ,  Nigericin

Reference (42)：

• Pugni L, Pietrasanta C, Acaia B, et al. Chorioamnionitis and neonatal outcome in preterm infants: a clinical overview. J Matern Fetal Neonatal Med. 2016;29: 1525-1529.
• Kim CJ, Romero R, Chaemsaithong P, Kim JS. Chronic inflammation of the placenta: definition, classification, pathogenesis, and clinical significance. Am J Obstet Gynecol. 2015;213(4 Suppl):S53-S69.
• Katzman PJ. Chronic inflammatory lesions of the placenta. Semin Perinatol. 2015;39:20-26.
• Benirschke K, Kaufmann P. Pathology of the Human Placenta. 4th ed. New York: Springer-Verlag; 2000.
• Yoshie M, Kaneyama K, Kusama K, et al. Possible role of the exchange protein directly activated by cyclic AMP (Epac) in the cyclic AMP-dependent functional differentiation and syncytialization of human placental BeWo cells. Hum Reprod. 2010;25:2229-2238.

Terms in the title (8)： グリベンクラミド ,  ヒト ,  トロホブラスト ,  NLRP3インフラマソーム ,  仲介 ,  IL-1β ,  分泌 ,  阻害