Immunohistochemical evaluation of Klotho and DNA methyltransferase 3a in oral squamous cell carcinomas

ADHIKARI Bhoj Raj; UEHARA Osamu; MATSUOKA Hirofumi; TAKAI Rie; HARADA Fumiya; UTSUNOMIYA Masafumi; CHUJO Takatoshi; MORIKAWA Tetsuro; SHAKYA Mamata; YOSHIDA Koki; SATO Jun; ARAKAWA Toshiya; NISHIMURA Michiko; NAGAYASU Hiroki; CHIBA Itsuo; ABIKO Yoshihiro

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J-GLOBAL ID：201702223000786001 Reference number：17A1150736

Immunohistochemical evaluation of Klotho and DNA methyltransferase 3a in oral squamous cell carcinomas

口腔扁平上皮癌におけるKlothoおよびDNAメチルトランスフェラーゼ3aの免疫組織化学的解析

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Material：
Volume： 50 Issue： 3 Page： 155-160 Publication year： Sep. 2017
JST Material Number： L1883A ISSN： 1860-1480 Document type： Article
Article type：原著論文 Country of issue： Germany, Federal Republic of (DEU) Language： ENGLISH (EN)

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Tumors(=neoplasms)of digestive system , Carcinogenic mechanisms and factors , Proteins and peptides in general

Reference (31)：

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Kuro-o M, Matsumura Y, Aizawa H, Kawaguchi H, Suga T, Utsugi T, Ohyama Y, Kurabayashi M, Kaname T, Kume E, Iwasaki H, Iida A, Shiraki-Iida T, Nishikawa S, Nagai R, Nabeshima Y (1997) Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 390:45-51
Xie B, Chen J, Liu B, Zhan J (2013) Klotho acts as a tumor suppressor in cancers. Pathol Oncol Res 19:611-617
Chen B, Wang X, Zhao W, Wu J (2010) Klotho inhibits growth and promotes apoptosis in human lung cancer cell line A549. J Exp Clin Cancer Res 29:99

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