Art

J-GLOBAL ID：201702223289203318   Reference number：17A0519368

Pd(II)-catalyzed cascade Heck/intramolecular C(sp ² )-H amidation reaction: An efficient route to 4-aryl-2-quinolinones

Pd(II)触媒化カスケードHeck/分子内C(sp²)-Hアミド化反応:4-アリール-2-キノリノンの効率的合成経路

Author (4)： Xiao Chengqian (State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, PR China) ,  Wang Ziyi (State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, PR China) ,  Lei Min (State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, PR China) ,  Hu Lihong (State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, PR China)
Material： Tetrahedron  (Tetrahedron Symposia-in-Print)
Volume： 73  Issue： 2  Page： 204-211  Publication year： Jan. 12, 2017 
JST Material Number： E0234A  ISSN： 0040-4020  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： *Heck reaction ,  *palladium catalyst ,  *consecutive reaction ,  *chemical reaction ,  *activation ,  amidation ,  aromatic iodine compound ,  reaction mechanism ,  proton magnetic resonance ,  13C NMR ,  Electrospray Ionization Mass Spectrometry ,  *chemical synthesis ,  *cascade reaction ,  intramolecular reaction ,  organic reaction mechanism ,  *drug synthesis ,  nitrogen heterocyclic compound ,  hydroxy compound ,  polynuclear aromatic compound ,  aromatic compound ,  olefin compound ,  carboxamide ,  unsaturated carboxylic acid
Semi thesaurus term： *Heck-type reaction ,  *C-H bond activation ,  amidation reaction ,  1H-NMR ,  C13NMR ,  ESI-MS

Author keywords (5)： 4-Aryl-2-quinolinone ,  C(sp ² )-H activation ,  Intramolecular amidation ,  Directing group ,  Cascade reaction

JST classification (5)： Quinolines,isoquinolines  (CF07096H) ,  Addition reaction,elimination reaction  (CF02030M) ,  Catalytic reactions(heterogeneous system)  (CB06100E) ,  Nobel metal catalysts  (CB06122I) ,  Synthesis of drugs  (GV01030F)

Substance index (18)： Diacetic acid palladium(II) salt ,  2-Quinolinol ,  Cinnamamide ,  1-[2-(2-Pyridinyl)ethyl]-4-(4-methoxyphenyl)quinoline-2(1H)-one ,  1-[2-(2-Pyridinyl)ethyl]-4-(3-methoxyphenyl)quinoline-2(1H)-one ,  1-[2-(2-Pyridinyl)ethyl]-4-phenylquinoline-2(1H)-one ,  1-[2-(2-Pyridinyl)ethyl]-4-(4-chlorophenyl)quinoline-2(1H)-one ,  1-[2-(2-Pyridinyl)ethyl]-4-(4-methylphenyl)quinoline-2(1H)-one ,  1-[2-(2-Pyridinyl)ethyl]-4-(4-fluorophenyl)quinoline-2(1H)-one ,  1-[2-(2-Pyridinyl)ethyl]-4-(4-nitrophenyl)quinoline-2(1H)-one ,  4-[1-[2-(2-Pyridinyl)ethyl]-2-oxo-1,2-dihydroquinoline-4-yl]benzonitrile ,  1-[2-(2-Pyridinyl)ethyl]-4-[4-(trifluoromethyl)phenyl]quinoline-2(1H)-one ,  4-[1-[2-(2-Pyridinyl)ethyl]-2-oxo-1,2-dihydroquinoline-4-yl]benzoic acid methyl ester ,  1-[2-(2-Pyridinyl)ethyl]-4-(4-methoxyphenyl)-6-methoxyquinoline-2(1H)-one ,  1-[2-(2-Pyridinyl)ethyl]-4-(4-methoxyphenyl)-6-methylquinoline-2(1H)-one ,  1-[2-(2-Pyridinyl)ethyl]-4-(4-methoxyphenyl)-6-nitroquinoline-2(1H)-one ,  1-[2-(2-Pyridinyl)ethyl]-4-(4-methoxyphenyl)-6-chloroquinoline-2(1H)-one ,  1-[2-(2-Pyridinyl)ethyl]-4-(4-methoxyphenyl)-6-fluoroquinoline-2(1H)-one

Terms in the title (6)： PD ,  触媒 ,  カスケード ,  アミド化反応 ,  2-キノリノン ,  合成経路